2020
Macrophage scavenger receptor 1 controls Chikungunya virus infection through autophagy in mice
Yang L, Geng T, Yang G, Ma J, Wang L, Ketkar H, Yang D, Lin T, Hwang J, Zhu S, Wang Y, Dai J, You F, Cheng G, Vella AT, Flavell RA, Fikrig E, Wang P. Macrophage scavenger receptor 1 controls Chikungunya virus infection through autophagy in mice. Communications Biology 2020, 3: 556. PMID: 33033362, PMCID: PMC7545163, DOI: 10.1038/s42003-020-01285-6.Peer-Reviewed Original ResearchConceptsMacrophage scavenger receptor 1Scavenger receptor 1Chikungunya virusReceptor 1Antiviral roleType I IFN responseChikungunya virus infectionLow-density lipoproteinImportant antiviral roleI IFN responseMarkers of autophagyCHIKV infectionViral loadArthritogenic alphavirusesVirus infectionCHIKV replicationATG5-ATG12Antiviral actionKnockout miceMSR1 expressionIFN responseInfectionMiceNsp1 proteinAutophagic function
2019
Inhibition of Chikungunya Virus Replication in Primary Human Fibroblasts by Liver X Receptor Agonist
Hwang J, Wang Y, Fikrig E. Inhibition of Chikungunya Virus Replication in Primary Human Fibroblasts by Liver X Receptor Agonist. Antimicrobial Agents And Chemotherapy 2019, 63: 10.1128/aac.01220-19. PMID: 31307983, PMCID: PMC6709483, DOI: 10.1128/aac.01220-19.Peer-Reviewed Original ResearchMeSH KeywordsAntiviral AgentsApolipoproteins EATP Binding Cassette Transporter 1ATP Binding Cassette Transporter, Subfamily G, Member 1Chikungunya virusCholesterolFibroblastsGene Expression RegulationHost-Pathogen InteractionsHumansIndazolesInterferonsLiver X ReceptorsPrimary Cell CultureRNA, Small InterferingSignal TransductionVirus ReplicationConceptsChikungunya virusLiver X receptor agonistMosquito-borne chikungunya virusX receptor agonistLiver X receptorChikungunya Virus ReplicationLXR-623Acute painJoint inflammationReceptor agonistCHIKV replicationPharmacological activationSynthetic agonistsAntiviral stateVirus replicationX receptorLarge epidemicsHost factorsAgonistsPrimary human fibroblastsVirusHuman fibroblastsPainInflammationGeographic areas