2016
Quantitative visual tests after poorly recovered optic neuritis due to multiple sclerosis
Longbrake EE, Lancia S, Tutlam N, Trinkaus K, Naismith RT. Quantitative visual tests after poorly recovered optic neuritis due to multiple sclerosis. Multiple Sclerosis And Related Disorders 2016, 10: 198-203. PMID: 27919490, PMCID: PMC5392253, DOI: 10.1016/j.msard.2016.10.009.Peer-Reviewed Original ResearchConceptsRetinal nerve fiber layerOptic neuritisVisual dysfunctionMS patientsContrast chartsVisual fieldVFQ-25 scoresPelli-Robson contrast sensitivity chartNerve fiber layerSevere visual dysfunctionSnellen eye chartLow contrast chartsCross-sectional studyContrast sensitivity testQuality of lifeContrast sensitivity chartLow-contrast testsOptical coherence tomographyMultiple sclerosisVisual acuityElectrophysiologic functionPatientsEye chartPR chartNeuritis
2011
Deficient CX3CR1 Signaling Promotes Recovery after Mouse Spinal Cord Injury by Limiting the Recruitment and Activation of Ly6Clo/iNOS+ Macrophages
Donnelly DJ, Longbrake EE, Shawler TM, Kigerl KA, Lai W, Tovar CA, Ransohoff RM, Popovich PG. Deficient CX3CR1 Signaling Promotes Recovery after Mouse Spinal Cord Injury by Limiting the Recruitment and Activation of Ly6Clo/iNOS+ Macrophages. Journal Of Neuroscience 2011, 31: 9910-9922. PMID: 21734283, PMCID: PMC3139517, DOI: 10.1523/jneurosci.2114-11.2011.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsAntigens, LyCD11 AntigensCells, CulturedChemokine CXCL1CX3C Chemokine Receptor 1Disease Models, AnimalFlow CytometryGene Expression RegulationGreen Fluorescent ProteinsMacrophagesMiceMice, Inbred C57BLMice, TransgenicMotor ActivityMyelin Basic ProteinNitric OxideNitric Oxide Synthase Type IIReceptors, ChemokineRecovery of FunctionSignal TransductionSpinal Cord InjuriesConceptsSpinal cord injuryMonocyte-derived macrophagesCord injuryMouse spinal cord injuryTraumatic spinal cord injuryBlockade of CX3CR1Novel monocyte subsetsCX3CR1-deficient miceAnti-inflammatory therapySelective anti-inflammatory therapyWild-type miceDistinct macrophage subsetsInflammatory cytokinesMonocyte subsetsChemokine receptorsFunctional improvementSpinal cordInflammatory signalingNeurotoxic effectsPromotes recoveryMacrophage subsetsLesion siteCX3CR1Oxidative metabolitesMice