2023
MOGAD patient autoantibodies induce complement, phagocytosis, and cellular cytotoxicity
Yandamuri S, Filipek B, Obaid A, Lele N, Thurman J, Makhani N, Nowak R, Guo Y, Lucchinetti C, Flanagan E, Longbrake E, O’Connor K. MOGAD patient autoantibodies induce complement, phagocytosis, and cellular cytotoxicity. JCI Insight 2023, 8: e165373. PMID: 37097758, PMCID: PMC10393237, DOI: 10.1172/jci.insight.165373.Peer-Reviewed Original ResearchConceptsMyelin oligodendrocyte glycoprotein antibody-associated diseaseAntibody-dependent cellular phagocytosisAntibody-dependent cellular cytotoxicityComplement-dependent cytotoxicityMOG autoantibodiesPatient seraCellular cytotoxicityEffector functionsComplement activityAntibody-associated diseaseMultiple mechanismsNK cellsPatient autoantibodiesCytotoxic capacityLesion histologyCellular phagocytosisFuture relapseIgG subclassesCerebrospinal fluidAutoantibodiesCNS conditionsMOGSerumRelapseCytotoxicity
2007
Characterization and modeling of monocyte‐derived macrophages after spinal cord injury
Longbrake EE, Lai W, Ankeny DP, Popovich PG. Characterization and modeling of monocyte‐derived macrophages after spinal cord injury. Journal Of Neurochemistry 2007, 102: 1083-1094. PMID: 17663750, DOI: 10.1111/j.1471-4159.2007.04617.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsB7-1 AntigenCD11b AntigenCytokinesDisease Models, AnimalFemaleFlow CytometryGene Expression RegulationHistocompatibility Antigens Class IIIn Vitro TechniquesMacrophagesMiceMice, Inbred C57BLPhagocytosisReverse Transcriptase Polymerase Chain ReactionRNA, MessengerSpinal Cord InjuriesTime FactorsConceptsSpinal cord injuryMonocyte-derived macrophagesBone marrow-derived macrophagesCord injurySpinal cordContext of SCIMarrow-derived macrophagesNeuroinflammatory reactionThioglycollate-elicited peritonealEffector cellsPeripheral macrophagesResident peritonealCytokine expressionLaser capture microdissectionReal-time PCRMacrophage subsetsMDM differentiationInjuryMacrophagesCapture microdissectionCordPeritonealMDM responseFunctional consequencesFuture studies