2017
Sudden Cardiac Death in Patients With Ischemic Heart Failure Undergoing Coronary Artery Bypass Grafting
Rao MP, Al-Khatib SM, Pokorney SD, She L, Romanov A, Nicolau JC, Lee KL, Carson P, Selzman CH, Stepinska J, Cleland JG, Tungsubutra W, Desvigne-Nickens PM, Sueta CA, Siepe M, Lang I, Feldman AM, Yii M, Rouleau JL, Velazquez EJ. Sudden Cardiac Death in Patients With Ischemic Heart Failure Undergoing Coronary Artery Bypass Grafting. Circulation 2017, 135: 1136-1144. PMID: 28154006, PMCID: PMC5516272, DOI: 10.1161/circulationaha.116.026075.Peer-Reviewed Original ResearchMeSH KeywordsAgedAtrial FibrillationCoronary Artery BypassDeath, Sudden, CardiacFemaleFollow-Up StudiesHeart FailureHumansHydroxymethylglutaryl-CoA Reductase InhibitorsIncidenceMaleMiddle AgedMultivariate AnalysisNatriuretic Peptide, BrainPostoperative PeriodProportional Hazards ModelsReceptors, Tumor Necrosis FactorRisk FactorsStroke VolumeVentricular Function, LeftConceptsCoronary artery bypass graft surgerySudden cardiac deathEnd-systolic volume indexB-type natriuretic peptideVentricular ejection fractionSurgical ventricular reconstructionCardiac deathEjection fractionHeart failureNatriuretic peptideVentricular reconstructionPreoperative end-systolic volume indexLow left ventricular ejection fractionIncidence of SCDPredictors of SCDArtery bypass graft surgeryCoronary Artery Bypass GraftingLeft ventricular ejection fractionVolume indexArtery Bypass GraftingBypass graft surgeryIschemic heart failureContemporary clinical trialsBlinded committeeSTICH trial
2013
Mechanisms of Functional Mitral Regurgitation in Ischemic Cardiomyopathy Determined by Transesophageal Echocardiography (from the Surgical Treatment for Ischemic Heart Failure Trial)
Golba K, Mokrzycki K, Drozdz J, Cherniavsky A, Wrobel K, Roberts BJ, Haddad H, Maurer G, Yii M, Asch FM, Handschumacher MD, Holly TA, Przybylski R, Kron I, Schaff H, Aston S, Horton J, Lee KL, Velazquez EJ, Grayburn PA, Investigators S. Mechanisms of Functional Mitral Regurgitation in Ischemic Cardiomyopathy Determined by Transesophageal Echocardiography (from the Surgical Treatment for Ischemic Heart Failure Trial). The American Journal Of Cardiology 2013, 112: 1812-1818. PMID: 24035166, PMCID: PMC3830629, DOI: 10.1016/j.amjcard.2013.07.047.Peer-Reviewed Original ResearchConceptsEnd-systolic volume indexLV end-systolic volume indexFunctional mitral regurgitationLV ejection fractionSeverity of MRMitral regurgitationVolume indexTenting areaIschemic cardiomyopathyMR gradeAnnulus areaVentricular end-systolic volume indexIschemic Heart Failure (STICH) trialSphericity indexHeart Failure TrialEffective regurgitant orifice areaPosterior leaflet angleMitral annulus areaMitral annulus diameterRegurgitant orifice areaSTICH trialSurgical treatmentEjection fractionFailure TrialTransesophageal echocardiography
2012
Insights from the STICH trial: Change in left ventricular size after coronary artery bypass grafting with and without surgical ventricular reconstruction
Michler RE, Rouleau JL, Al-Khalidi HR, Bonow RO, Pellikka PA, Pohost GM, Holly TA, Oh JK, Dagenais F, Milano C, Wrobel K, Pirk J, Ali IS, Jones RH, Velazquez EJ, Lee KL, Di Donato M, Investigators S. Insights from the STICH trial: Change in left ventricular size after coronary artery bypass grafting with and without surgical ventricular reconstruction. Journal Of Thoracic And Cardiovascular Surgery 2012, 146: 1139-1145.e6. PMID: 23111018, PMCID: PMC3810307, DOI: 10.1016/j.jtcvs.2012.09.007.Peer-Reviewed Original ResearchConceptsEnd-systolic volume indexCoronary artery bypassSurgical ventricular reconstructionVentricular reconstructionArtery bypassVolume indexSurvival benefitML/Ischemic heart failureSignificant survival benefitEnd-systolic volumeLeft ventricular volumeSTICH trialPostoperative reductionHeart failureImproved survivalSurgical treatmentClinical benefitVentricular sizeImaging assessmentTreatment groupsVentricular volumePatientsBypassTrial dataInfluence of baseline left ventricular function on the clinical outcome of surgical ventricular reconstruction in patients with ischaemic cardiomyopathy
Oh JK, Velazquez EJ, Menicanti L, Pohost GM, Bonow RO, Lin G, Hellkamp AS, Ferrazzi P, Wos S, Rao V, Berman D, Bochenek A, Cherniavsky A, Rogowski J, Rouleau JL, Lee KL, Investigators O. Influence of baseline left ventricular function on the clinical outcome of surgical ventricular reconstruction in patients with ischaemic cardiomyopathy. European Heart Journal 2012, 34: 39-47. PMID: 22584648, PMCID: PMC3533917, DOI: 10.1093/eurheartj/ehs021.Peer-Reviewed Original ResearchConceptsEnd-systolic volume indexSurgical ventricular reconstructionRegional wall motion abnormalitiesWall motion abnormalitiesEjection fractionBetter LVEFIschemic cardiomyopathyVentricular reconstructionMotion abnormalitiesLV end-systolic volume indexMedian end-systolic volume indexBaseline left ventricular functionIschemic Heart Failure (STICH) trialEnd-diastolic volume indexVolume indexBaseline LV functionCoronary artery bypassHeart Failure TrialLeft ventricular functionClinical trial registrationLeft ventricular function parametersLV global functionVentricular function parametersCardiovascular magnetic resonanceML/m2
2009
Coronary Bypass Surgery with or without Surgical Ventricular Reconstruction
Jones RH, Velazquez EJ, Michler RE, Sopko G, Oh JK, O'Connor CM, Hill JA, Menicanti L, Sadowski Z, Desvigne-Nickens P, Rouleau JL, Lee KL. Coronary Bypass Surgery with or without Surgical Ventricular Reconstruction. New England Journal Of Medicine 2009, 360: 1705-1717. PMID: 19329820, PMCID: PMC3265934, DOI: 10.1056/nejmoa0900559.Peer-Reviewed Original ResearchConceptsSurgical ventricular reconstructionCoronary artery diseaseVentricular reconstructionRate of deathCardiac causesLeft ventricular volumeArtery diseasePrimary outcomeVentricular volumeEnd-systolic volume indexComposite of deathCoronary artery bypassCoronary bypass surgeryLeft ventricular dysfunctionVentricular dysfunctionBypass surgeryCardiac symptomsEjection fractionHeart failureCABGStudy groupPatientsVolume indexHospitalizationAnatomical changes