2024
Restrictive versus liberal red blood cell transfusion strategies for people with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem cell support
Radford M, Estcourt L, Sirotich E, Pitre T, Britto J, Watson M, Brunskill S, Fergusson D, Dorée C, Arnold D. Restrictive versus liberal red blood cell transfusion strategies for people with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem cell support. 2024, 2024: cd011305. PMID: 38780066, PMCID: PMC11112982, DOI: 10.1002/14651858.cd011305.pub3.Peer-Reviewed Original ResearchConceptsRed blood cell transfusion strategyHaematopoietic stem cell transplantationLiberal transfusion strategyClinically significant bleedingRestrictive transfusion strategyNon-randomised studiesTransfusion strategyIntensive chemotherapyRandomised controlled trialsRed blood cellsSignificant bleedingAll-cause mortalityLength of hospital admissionAcute leukemiaHaematological malignanciesRisk of clinically significant bleedingHaematopoietic stem cell supportProspective non-randomised studyRisk ratioControlled trialsQuality of lifeStem cell supportStem cell transplantationMalignant haematological disordersCochrane Central Register of Controlled Trials
2023
Impact of iron supplementation on patient outcomes for women with abnormal uterine bleeding: a protocol for a systematic review and meta-analysis
Nazaryan H, Watson M, Ellingham D, Thakar S, Wang A, Pai M, Liu Y, Rochwerg B, Gabarin N, Arnold D, Sirotich E, Zeller M. Impact of iron supplementation on patient outcomes for women with abnormal uterine bleeding: a protocol for a systematic review and meta-analysis. Systematic Reviews 2023, 12: 121. PMID: 37443063, PMCID: PMC10347734, DOI: 10.1186/s13643-023-02222-4.Peer-Reviewed Original ResearchConceptsIron deficiency anemiaQuality of lifeHeavy menstrual bleedingStandard of carePatient outcomesIron interventionsSystematic reviewUterine bleedingCombination therapyIron supplementationIron indicesRed blood cell transfusionIron deficiencyRed blood cell utilizationAbnormal uterine bleedingIntraoperative blood lossBlood cell transfusionEvidence-based clinical practiceMeta-analyzed outcomesSystematic literature searchCost of treatmentWeb of ScienceCell transfusionHospital stayAdverse events