2020
Use of CT simulation and 3-D radiation therapy treatment planning system to develop and validate a total-body irradiation technique for the New Zealand White rabbit
Poirier Y, Prado C, Prado K, Draeger E, Jackson IL, Vujaskovic Z. Use of CT simulation and 3-D radiation therapy treatment planning system to develop and validate a total-body irradiation technique for the New Zealand White rabbit. International Journal Of Radiation Biology 2020, 97: s10-s18. PMID: 32924716, DOI: 10.1080/09553002.2019.1665215.Peer-Reviewed Original ResearchConceptsNew Zealand white rabbitsAcute radiation syndromeDose-response relationshipZealand white rabbitsTBI techniquePrescribed doseAverage doseWhite rabbitsTotal body irradiation (TBI) exposureRadiation dose-response relationshipTotal body irradiation techniqueMedical countermeasure efficacyMonitor unitsLeft decubitus positionTreatment planning systemMaximal doseRadiation syndromeIndividual organ dosesAnimal modelsRadiotherapy techniquesTherapy treatment planning systemCountermeasure efficacyExperienced dosimetristDecreased attenuationDose homogeneity
2019
Hematological Effects of Non-Homogenous Ionizing Radiation Exposure in a Non-Human Primate Model
Jackson IL, Gibbs A, Poirier Y, Wathen L, Eley J, Draeger E, Gopalakrishnan M, Benjamin B, Vujaskovic Z. Hematological Effects of Non-Homogenous Ionizing Radiation Exposure in a Non-Human Primate Model. Radiation Research 2019, 191: 428-438. PMID: 30870098, DOI: 10.1667/rr15280.1.Peer-Reviewed Original ResearchConceptsLower half-body irradiationUpper half body irradiationHalf-body irradiationTotal body irradiationDose-volume effectsNon-human primatesBM toxicityRadiation exposureBone marrowClinical signs/symptomsRadiation dose-volume effectsNon-human primate modelHigh-grade feverSigns/symptomsBone marrow toxicityPeripheral blood samplesAcute radiation syndromeIonizing Radiation ExposureBlood-forming organsSevere neutropeniaRespiratory distressHematologic changesMarrow toxicityBM damagePrimate model