2024
Dissecting reactive astrocyte responses: lineage tracing and morphology-based clustering
Delgado-García L, Ojalvo-Sanz A, Nakamura T, Martín-López E, Porcionatto M, Lopez-Mascaraque L. Dissecting reactive astrocyte responses: lineage tracing and morphology-based clustering. Biological Research 2024, 57: 54. PMID: 39143594, PMCID: PMC11323641, DOI: 10.1186/s40659-024-00532-y.Peer-Reviewed Original Research
2023
Microglia Maintain Homeostatic Conditions in the Developing Rostral Migratory Stream
Meller S, Hernandez L, Martin-Lopez E, Kloos Z, Liberia T, Greer C. Microglia Maintain Homeostatic Conditions in the Developing Rostral Migratory Stream. ENeuro 2023, 10: eneuro.0197-22.2023. PMID: 36697258, PMCID: PMC9910579, DOI: 10.1523/eneuro.0197-22.2023.Peer-Reviewed Original Researchα-Synuclein Pathology and Reduced Neurogenesis in the Olfactory System Affect Olfaction in a Mouse Model of Parkinson's Disease
Martin-Lopez E, Vidyadhara D, Liberia T, Meller S, Harmon L, Hsu R, Spence N, Brennan B, Han K, Yücel B, Chandra S, Greer C. α-Synuclein Pathology and Reduced Neurogenesis in the Olfactory System Affect Olfaction in a Mouse Model of Parkinson's Disease. Journal Of Neuroscience 2023, 43: 1051-1071. PMID: 36596700, PMCID: PMC9908323, DOI: 10.1523/jneurosci.1526-22.2022.Peer-Reviewed Original ResearchConceptsΑ-syn tg miceΑ-Syn pathologyOlfactory bulb neurogenesisProjection neuronsParkinson's diseaseOlfactory dysfunctionMutant α-synucleinOlfactory deficitsOlfactory pathwaySyn pathologyBehavioral deficitsMouse modelΑ-synucleinOB granule cellsΑ-synuclein pathologyOlfactory systemMonths of ageReduced neurogenesisFunctional deficitsPeriglomerular cellsMotor progressionPathologic changesMultiple symptomsSynaptic terminalsGranule cells
2019
Embryonic and postnatal development of mouse olfactory tubercle
Martin-Lopez E, Xu C, Liberia T, Meller SJ, Greer CA. Embryonic and postnatal development of mouse olfactory tubercle. Molecular And Cellular Neuroscience 2019, 98: 82-96. PMID: 31200100, DOI: 10.1016/j.mcn.2019.06.002.Peer-Reviewed Original ResearchConceptsOlfactory tubercleVentral striatumOlfactory bulb projection neuronsPrimary afferent inputTyrosine hydroxylase expressionLateral ganglionic eminenceDopamine reward systemCNPase stainingVentral medial regionDopaminergic innervationProjection neuronsStriatal neuronsVentral tegmentumAfferent inputDopaminergic inputLaminar distributionMedial gradientHydroxylase expressionNucleus accumbensGanglionic eminencePostnatal developmentE11-E15OT cellsVentral lateral ganglionic eminencePostnatal stages
2018
Development of piriform cortex interhemispheric connections via the anterior commissure: progressive and regressive strategies
Martin-Lopez E, Meller SJ, Greer CA. Development of piriform cortex interhemispheric connections via the anterior commissure: progressive and regressive strategies. Brain Structure And Function 2018, 223: 4067-4085. PMID: 30141078, PMCID: PMC6252112, DOI: 10.1007/s00429-018-1741-y.Peer-Reviewed Original ResearchConceptsAnterior commissurePostnatal developmentPostnatal day 22Inter-hemispheric connectionsChondroitin sulfate proteoglycanPiriform cortexContralateral innervationGlial cellsOlfactory areasBed nucleusInterhemispheric connectionsStria terminalisDay 22Axonal tractsAxon growthNew subtypeAxon outgrowthCalretininCommissureSulfate proteoglycanAxonsPhenotypeInnervationIpsiImmunohistochemistry
2017
The Laminar Organization of Piriform Cortex Follows a Selective Developmental and Migratory Program Established by Cell Lineage
Martin-Lopez E, Ishiguro K, Greer CA. The Laminar Organization of Piriform Cortex Follows a Selective Developmental and Migratory Program Established by Cell Lineage. Cerebral Cortex 2017, 29: 1-16. PMID: 29136113, PMCID: PMC7199997, DOI: 10.1093/cercor/bhx291.Peer-Reviewed Original ResearchConceptsLaminar specificityLaminar organizationNeurogenesis/gliogenesisPrimary afferent inputNeurogenic patternPiriform cortexAfferent inputNeurogenic gradientOlfactory bulbLayers IIGlial organizationNeuronal migrationPC progenitorsLaminar developmentCortexFunctional organizationClonal analysisCell lineagesLikely roleEarly developmentPaleocortexAnteriorNeurogenesisSpecificityGliogenesis
2015
Decoding astrocyte heterogeneity: New tools for clonal analysis
Bribián A, Figueres-Oñate M, Martín-López E, López-Mascaraque L. Decoding astrocyte heterogeneity: New tools for clonal analysis. Neuroscience 2015, 323: 10-19. PMID: 25917835, DOI: 10.1016/j.neuroscience.2015.04.036.Peer-Reviewed Original ResearchConceptsEmbryonic developmentAstrocyte lineagePowerful genetic toolsBiology of astrocytesGenetic toolsCell heterogeneityLineagesOntogenetic originAstrocyte heterogeneityClonal analysisPhysiological featuresSpecific labelingAstrocyte progenitorsClonesAdult brainCell clonesAstrocyte clonesFinal fateExciting areaNew toolProgenyBiologyProgenitors
2013
Clonal Astrocytic Response to Cortical Injury
Martín-López E, García-Marques J, Núñez-Llaves R, López-Mascaraque L. Clonal Astrocytic Response to Cortical Injury. PLOS ONE 2013, 8: e74039. PMID: 24040158, PMCID: PMC3769363, DOI: 10.1371/journal.pone.0074039.Peer-Reviewed Original ResearchConceptsDays post injuryHigher proliferative responsesCentral nervous systemCortical injuryStrong morphological alterationsAstrocytic responsePost injuryBrain injuryGlial functionGlial cellsProliferative responseImmunohistochemical analysisNervous systemAstrocyte heterogeneitySame cloneInjuryMechanical injuryAstrocytesMorphological alterationsClonal responseHeterogeneous populationDistinct clonesCell lineagesMorphological changesMultifaceted roleInfluence of Chitosan Concentration on Cell Viability and Proliferation in Vitro by Changing Film Topography
Martín-López E, Nieto-Díaz M, Nieto-Sampedro M. Influence of Chitosan Concentration on Cell Viability and Proliferation in Vitro by Changing Film Topography. Journal Of Applied Biomaterials & Functional Materials 2013, 11: 151-158. PMID: 23413128, DOI: 10.5301/jabfm.2012.10449.Peer-Reviewed Original ResearchConceptsChitosan filmsAtomic force microscopyFilm topographyTissue engineering applicationsChitosan concentrationPolymer surface topographyNeural tissue engineeringEnvironmental scanning electron microscopyScanning electron microscopyEngineering applicationsSurface topographyTissue engineeringAFM profilesFilmsForce microscopyTopography changesVitro biological propertiesChitosan solutionElectron microscopyChitosan polymerAlkaline precipitationNatural polysaccharidesTopographyPropertiesBridgeAgar-based bridges as biocompatible candidates to provide guide cues in spinal cord injury repair.
Martín-López E, Darder M, Ruiz-Hitzky E, Nieto Sampedro M. Agar-based bridges as biocompatible candidates to provide guide cues in spinal cord injury repair. Bio-Medical Materials And Engineering 2013, 23: 405-21. PMID: 23988711, DOI: 10.3233/bme-130763.Peer-Reviewed Original ResearchConceptsEnvironmental scanning electron microscopyScanning electron microscopyPorous structureBridge materialsBiomaterial propertiesCell ingrowthChannel linearityMixture of agarGrowth surfaceXanthan gumStability of gelsElectron microscopyEmpty channelsBiopolymer structuresPolysulfoneMatrix scaffoldsBiocompatible candidateΚ-carrageenanClosed contactBridgeMaterialsGel mixtureMixtureSpinal cord injury repairStability
2012
Chitosan, Gelatin and Poly(L-Lysine) Polyelectrolyte-Based Scaffolds and Films for Neural Tissue Engineering
Martín-López E, Alonso FR, Nieto-Díaz M, Nieto-Sampedro M. Chitosan, Gelatin and Poly(L-Lysine) Polyelectrolyte-Based Scaffolds and Films for Neural Tissue Engineering. Journal Of Biomaterials Science Polymer Edition 2012, 23: 207-232. PMID: 21192838, DOI: 10.1163/092050610x546426.Peer-Reviewed Original ResearchConceptsNeural tissue engineeringTissue engineeringG filmsSmall pore sizeThermal resistancePore sizeSuitable materialBiomaterial implantsFilmsBest mixturePromising candidateEngineeringDorsal root gangliaDifferent physicochemical approachesDistinct electrostatic interactionsTraumatic nerve damageSpindle cell morphologyGel morphologyGlial cell growthNerve damage
2011
Dab1 (Disable Homolog-1) Reelin Adaptor Protein Is Overexpressed in the Olfactory Bulb at Early Postnatal Stages
Martín-López E, Blanchart A, De Carlos JA, López-Mascaraque L. Dab1 (Disable Homolog-1) Reelin Adaptor Protein Is Overexpressed in the Olfactory Bulb at Early Postnatal Stages. PLOS ONE 2011, 6: e26673. PMID: 22046330, PMCID: PMC3201967, DOI: 10.1371/journal.pone.0026673.Peer-Reviewed Original ResearchConceptsWild-type miceOlfactory bulb layersEarly postnatal stagesDab1 expressionEarly brain developmentProjection neuronsReeler miceOlfactory bulbType miceBrain developmentPostnatal stagesProtein expressionBulb layersExpression levelsDab1MiceNeuronsReelin effectsPresent studyReelerRELNCritical rolePossible regulationApparent differencesAdaptor protein
2010
Peripheral contributions to olfactory bulb cell populations (migrations towards the olfactory bulb)
Blanchart A, Martín‐López E, De Carlos JA, López‐Mascaraque L. Peripheral contributions to olfactory bulb cell populations (migrations towards the olfactory bulb). Glia 2010, 59: 278-292. PMID: 21125652, DOI: 10.1002/glia.21100.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnimalsAnimals, NewbornBromodeoxyuridineCell MovementCell ProliferationCells, CulturedEmbryo, MammalianFemaleGene Expression Regulation, DevelopmentalGene Transfer TechniquesGreen Fluorescent ProteinsMiceNerve Tissue ProteinsNeurogliaNeuronsOlfactory BulbOlfactory PathwaysPregnancyProsencephalonConceptsMigratory massCell populationsOlfactory axonsDifferent neural cell populationsOlfactory placodeOlfactory Ensheathing CellsCentral nervous systemLater postnatal stagesEmbryonic day 11Glial markersRetroviral injectionCNS neuronsNeural cell populationsGlomerular layerOlfactory nerveOlfactory bulbPeripheral contributionsNervous systemOlfactory epitheliumDifferent cell populationsDay 11Telencephalic vesiclePostnatal stagesInfected cellsOlfactory systemDifferential Adhesiveness and Neurite-promoting Activity for Neural Cells of Chitosan, Gelatin, and Poly-l-Lysine Films
Martín-López E, Nieto-Díaz M, Nieto-Sampedro M. Differential Adhesiveness and Neurite-promoting Activity for Neural Cells of Chitosan, Gelatin, and Poly-l-Lysine Films. Journal Of Biomaterials Applications 2010, 26: 791-809. PMID: 20876636, DOI: 10.1177/0885328210379928.Peer-Reviewed Original ResearchConceptsG filmsDorsal root gangliaTissue engineeringExcellent adhesive propertiesComposite filmsGood adhesionGood biomaterialFilmsPC12 cellsNGF-differentiated PC12 cellsC6 glioma cellsAdhesive propertiesRoot gangliaGlial cellsCerebral tissueHippocampal neuronsNerve repairMixture of CHGlioma cellsC6 lineTissue regenerationNeural cellsLysine filmsNeuronsEngineering
2006
Gelation under dynamic conditions: A strategy for in vitro cell ordering
Doncel-Pérez E, Darder M, Martín-López E, Vázquez L, Nieto-Sampedro M, Ruiz-Hitzky E. Gelation under dynamic conditions: A strategy for in vitro cell ordering. Journal Of Materials Science: Materials In Medicine 2006, 17: 795-802. PMID: 16932860, DOI: 10.1007/s10856-006-9837-y.Peer-Reviewed Original ResearchConceptsSpin-coating conditionsAtomic force microscopyNeuronal process outgrowthLow-temperature scanning electron microscopyScanning electron microscopyBiodegradable substrateRat C6 glioma cellsFluorescence microscopyCentrifugal forceCell orderingDynamic conditionsC6 glioma cellsForce microscopyProcess outgrowthAxon growthFibrin hydrogelsUniform distributionCell modelGlioma cellsC6 cellsElectron microscopy