2020
Clinical outcomes of COVID-19 in long-term care facilities for people with epilepsy
Balestrini S, Koepp M, Gandhi S, Rickman H, Shin G, Houlihan C, Anders-Cannon J, Silvennoinen K, Xiao F, Zagaglia S, Hudgell K, Ziomek M, Haimes P, Sampson A, Parker A, Cross J, Pardington R, Nastouli E, Swanton C, Consortium C, Aitken J, Allen Z, Ambler R, Ambrose K, Ashton E, Avola A, Balakrishnan S, Barns-Jenkins C, Barr G, Barrell S, Basu S, Beale R, Beesley C, Bhardwaj N, Bibi S, Bineva-Todd G, Biswas D, Blackman M, Bonnet D, Bowker F, Broncel M, Brooks C, Buck M, Buckton A, Budd T, Burrell A, Busby L, Bussi C, Butterworth S, Byott M, Byrne F, Byrne R, Caidan S, Campbell J, Canton J, Cardoso A, Carter N, Carvalho L, Carzaniga R, Chandler N, Chen Q, Cherepanov P, Churchward L, Clark G, Clayton B, Gigli C, Collins Z, Cottrell S, Crawford M, Cubitt L, Cullup T, Davies H, Davis P, Davison D, Dearing V, Debaisieux S, Diaz-Romero M, Dibbs A, Diring J, Driscoll P, D'Avola A, Earl C, Edwards A, Ekin C, Evangelopoulos D, Faraway R, Fearns A, Ferron A, Fidanis E, Fitz D, Fleming J, Frampton D, Frederico B, Gaiba A, Gait A, Gamblin S, Gärtner K, Gaul L, Golding H, Goldman J, Goldstone R, Dominguez B, Gong H, Grant P, Greco M, Grobler M, Guedan A, Gutierrez M, Hackett F, Hall R, Halldorsson S, Harris S, Hashim S, Hatipoglu E, Healy L, Heaney J, Herbst S, Hewitt G, Higgins T, Hindmarsh S, Hirani R, Hope J, Horton E, Hoskins B, Howell M, Howitt L, Hoyle J, Htun M, Hubank M, Encabo H, Hughes D, Hughes J, Huseynova A, Hwang M, Instrell R, Jackson D, Jamal-Hanjani M, Jenkins L, Jiang M, Johnson M, Jones L, Kanu N, Kassiotis G, Kelly G, Kiely L, Teixeira A, Kirk S, Kjaer S, Knuepfer E, Komarov N, Kotzampaltiris P, Kousis K, Krylova T, Kucharska A, Labrum R, Lambe C, Lappin M, Lee S, Levett A, Levett L, Levi M, Liu, Loughlin S, Lu W, MacRae J, Madoo A, Marczak J, Martensson M, Martinez T, Marzook B, Matthews J, Matz J, McCall S, McCoy L, McKay F, McNamara E, Minutti C, Mistry G, Molina-Arcas M, Montaner B, Montgomery K, Moore C, Moore D, Moraiti A, Moreira-Teixeira L, Mukherjee J, Naceur-Lombardelli C, Nelson A, Nicod J, Nightingale L, Nofal S, Nurse P, Nutan S, Oedekoven C, O'Garra A, O'Leary J, Olsen J, O'Neill O, O'Reilly N, Suarez P, Osborne N, Pabari A, Pajak A, Papayannopoulos V, Paraskevopoulou S, Patel N, Patel Y, Paun O, Peat N, Castano L, Caballero A, Perez-Lloret J, Perrault M, Perrin A, Poh R, Poirier E, Polke J, Pollitt M, Prieto-Godino L, Proust A, Puvirajasinghe C, Queval C, Ramachandran V, Ramaprasad A, Ratcliffe P, Reed L, Reis e Sousa C, Richardson K, Ridewood S, Roberts F, Roberts R, Rodgers A, Clavijo P, Rosa A, Rossi A, Roustan C, Rowan A, Sahai E, Sait A, Sala K, Sanchez E, Sanderson T, Santucci P, Sardar F, Sateriale A, Saunders J, Sawyer C, Schlott A, Schweighoffer E, Segura-Bayona S, Punatar R, Shahmanesh M, Shaw J, Dos Santos M, Silvestre M, Singer M, Snell D, Song O, Spyer M, Steel L, Strange A, Sullivan A, Tan M, Tautz-Davis Z, Taylor E, Taylor G, Taylor H, Taylor-Beadling A, Subtil F, Torras B, Toolan-Kerr P, Torelli F, Toteva T, Treeck M, Trojer H, Tsai M, Turner J, Turner M, Ule J, Ulferts R, Vanloo S, Veeriah S, Venkatesan S, Vousden K, Wack A, Walder C, Walker P, Wang Y, Ward S, Wenman C, Williams L, Williams M, Wong W, Wright J, Wu M, Wynne L, Xiang Z, Yap M, Zagalak J, Zecchin D, Zillwood R, Sander J, Sisodiya S, Consortium: C, Carthiyaniamma S, DeTisi J, Dick J, Hill A, Kipper K, Kullar B, Norris S, Rugg-Gunn F, Salvatierra R, Shaya G, Sloan A, Singh P, Varley J, Whatley B. Clinical outcomes of COVID-19 in long-term care facilities for people with epilepsy. Epilepsy & Behavior 2020, 115: 107602. PMID: 33279440, PMCID: PMC7643621, DOI: 10.1016/j.yebeh.2020.107602.Peer-Reviewed Original ResearchConceptsLong-term care facilitiesCare facilitiesChalfont Centre for EpilepsyResident-to-residentCo-morbiditiesCOVID-19 residentsPreventive measuresMeasured infection ratesCaregiver's levelOne-off testMultiple co-morbiditiesVulnerable peopleCaregiversEpilepsy-related factorsHospital admissionCohort studySymptomatic casesInfection preventionAsymptomatic peopleCOVID-19Clinical outcomes of COVID-19Rates of morbidityAsymptomatic individualsYoung adultsOutcomes of COVID-19Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers
Houlihan C, Vora N, Byrne T, Lewer D, Kelly G, Heaney J, Gandhi S, Spyer M, Beale R, Cherepanov P, Moore D, Gilson R, Gamblin S, Kassiotis G, McCoy L, Swanton C, Consortium C, Hayward A, Nastouli E, Investigators S, Aitken J, Allen Z, Ambler R, Ambrose K, Ashton E, Avola A, Balakrishnan S, Barns-Jenkins C, Barr G, Barrell S, Basu S, Beale R, Beesley C, Bhardwaj N, Bibi S, Bineva-Todd G, Biswas D, Blackman M, Bonnet D, Bowker F, Broncel M, Brooks C, Buck M, Buckton A, Budd T, Burrell A, Busby L, Bussi C, Butterworth S, Byrne F, Byrne R, Caidan S, Campbell J, Canton J, Cardoso A, Carter N, Carvalho L, Carzaniga R, Chandler N, Chen Q, Cherepanov P, Churchward L, Clark G, Clayton B, Gigli C, Collins Z, Cottrell S, Crawford M, Cubitt L, Cullup T, Davies H, Davis P, Davison D, D'Avola A, Dearing V, Debaisieux S, Diaz-Romero M, Dibbs A, Diring J, Driscoll P, Earl C, Edwards A, Ekin C, Evangelopoulos D, Faraway R, Fearns A, Ferron A, Fidanis E, Fitz D, Fleming J, Frederico B, Gaiba A, Gait A, Gamblin S, Gandhi S, Gaul L, Golding H, Goldman J, Goldstone R, Dominguez B, Gong H, Grant P, Greco M, Grobler M, Guedan A, Gutierrez M, Hackett F, Hall R, Halldorsson S, Harris S, Hashim S, Healy L, Heaney J, Herbst S, Hewitt G, Higgins T, Hindmarsh S, Hirani R, Hope J, Horton E, Hoskins B, Houlihan C, Howell M, Howitt L, Hoyle J, Htun M, Hubank M, Encabo H, Hughes D, Hughes J, Huseynova A, Hwang M, Instrell R, Jackson D, Jamal-Hanjani M, Jenkins L, Jiang M, Johnson M, Jones L, Kanu N, Kassiotis G, Kiely L, Teixeira A, Kirk S, Kjaer S, Knuepfer E, Komarov N, Kotzampaltiris P, Kousis K, Krylova T, Kucharska A, Labrum R, Lambe C, Lappin M, Lee S, Levett A, Levett L, Levi M, Liu H, Loughlin S, Lu W, MacRae J, Madoo A, Marczak J, Martensson M, Martinez T, Marzook B, Matthews J, Matz J, McCall S, McCoy L, McKay F, McNamara E, Minutti C, Mistry G, Molina-Arcas M, Montaner B, Montgomery K, Moore C, Moore D, Moraiti A, Moreira-Teixeira L, Mukherjee J, Naceur-Lombardelli C, Nastouli E, Nelson A, Nicod J, Nightingale L, Nofal S, Nurse P, Nutan S, Oedekoven C, O'Garra A, O'Leary J, Olsen J, O'Neill O, Suarez P, O'Reilly N, Osborne N, Pabari A, Pajak A, Papayannopoulos V, Patel N, Patel Y, Paun O, Peat N, Castano L, Caballero A, Perez-Lloret J, Perrault M, Perrin A, Poh R, Poirier E, Polke J, Pollitt M, Prieto-Godino L, Proust A, Punatar R, Puvirajasinghe C, Queval C, Ramachandran V, Ramaprasad A, Ratcliffe P, Reed L, Reis e Sousa C, Richardson K, Ridewood S, Roberts R, Rodgers A, Clavijo P, Rosa A, Rossi A, Roustan C, Rowan A, Sahai E, Sait A, Sala K, Sanderson T, Santucci P, Sardar F, Sateriale A, Saunders J, Sawyer C, Schlott A, Schweighoffer E, Segura-Bayona S, Shaw J, Shin G, Dos Santos M, Silvestre M, Singer M, Snell D, Song O, Spyer M, Steel L, Strange A, Sullivan A, Swanton C, Tan M, Tautz-Davis Z, Taylor E, Taylor G, Taylor H, Taylor-Beadling A, Subtil F, Torras B, Toolan-Kerr P, Torelli F, Toteva T, Treeck M, Trojer H, Tsai M, Turner J, Turner M, Ule J, Ulferts R, Vanloo S, Veeriah S, Venkatesan S, Vousden K, Wack A, Walder C, Walker P, Wang Y, Ward S, Wenman C, Wiliams L, Williams M, Wong W, Wright J, Wu M, Wynne L, Xiang Z, Yap M, Zagalak J, Zecchin D, Zillwood R, Matthews R, Severn A, Adam S, Enfield L, McBride A, Gärtner K, Edwards S, Lorencatto F, Michie S, Manley E, Shahmanesh M, Lukha H, Prymas P, McBain H, Shortman R, Wood L, Davies C, Williams B, Ng K, Cornish G, Faulkner N, Riddell A, Hobson P, Agua-Doce A, Bartolovic K, Russell E, Carr L, Sanchez E, Frampton D, Byott M, Paraskevopoulou S, Crayton E, Meyer C, Vora N, Gkouleli T, Stoltenberg A, Ranieri V, Byrne T, Lewer D, Hayward A, Gilson R, Kelly G, Roberts F, Hatipoglu E. Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers. The Lancet 2020, 396: e6-e7. PMID: 32653078, PMCID: PMC7347344, DOI: 10.1016/s0140-6736(20)31484-7.Peer-Reviewed Original Research
2019
Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse
Chemi F, Rothwell D, McGranahan N, Gulati S, Abbosh C, Pearce S, Zhou C, Wilson G, Jamal-Hanjani M, Birkbak N, Pierce J, Kim C, Ferdous S, Burt D, Slane-Tan D, Gomes F, Moore D, Shah R, Al Bakir M, Hiley C, Veeriah S, Summers Y, Crosbie P, Ward S, Mesquita B, Dynowski M, Biswas D, Tugwood J, Blackhall F, Miller C, Hackshaw A, Brady G, Swanton C, Dive C. Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse. Nature Medicine 2019, 25: 1534-1539. PMID: 31591595, PMCID: PMC6986897, DOI: 10.1038/s41591-019-0593-1.Peer-Reviewed Original ResearchConceptsNon-small-cell lung cancerEarly-stage non-small-cell lung cancerDisease relapseGenomic profilingHigh risk of recurrenceDetection of circulating tumor cellsRisk of recurrenceTumor cell disseminationTime of surgeryPredictors of relapsePotential clinical utilityCurative intentPrimary tumorSurgical resectionTumor resectionTumor stagePredicting relapseCell disseminationTumor cellsLung cancerMutational overlapRelapseMultivariate analysisSurgeryHigh risk