2023
Tracking early lung cancer metastatic dissemination in TRACERx using ctDNA
Abbosh C, Frankell A, Harrison T, Kisistok J, Garnett A, Johnson L, Veeriah S, Moreau M, Chesh A, Chaunzwa T, Weiss J, Schroeder M, Ward S, Grigoriadis K, Shahpurwalla A, Litchfield K, Puttick C, Biswas D, Karasaki T, Black J, Martínez-Ruiz C, Bakir M, Pich O, Watkins T, Lim E, Huebner A, Moore D, Godin-Heymann N, L’Hernault A, Bye H, Odell A, Roberts P, Gomes F, Patel A, Manzano E, Hiley C, Carey N, Riley J, Cook D, Hodgson D, Stetson D, Barrett J, Kortlever R, Evan G, Hackshaw A, Daber R, Shaw J, Aerts H, Licon A, Stahl J, Jamal-Hanjani M, Birkbak N, McGranahan N, Swanton C. Tracking early lung cancer metastatic dissemination in TRACERx using ctDNA. Nature 2023, 616: 553-562. PMID: 37055640, PMCID: PMC7614605, DOI: 10.1038/s41586-023-05776-4.Peer-Reviewed Original ResearchConceptsCirculating tumor DNANon-small-cell lung cancerMetastatic disseminationClinical outcomesPlasma samplesEarly-stage non-small-cell lung cancerCirculating tumor DNA levelsCirculating tumor DNA detectionCytotoxic adjuvant therapyPreoperative ctDNA detectionResidual tumor cellsLongitudinal plasma samplesCancer cell fractionBiomarker of relapseProcess of metastatic disseminationAnalysis of plasma samplesClinical relapseDisease relapseAdjuvant therapyTumor DNAPreoperative plasmaRadiological surveillanceCtDNA detectionPatient cohortTumor cells
2021
Abstract LB258: Branching cancer evolution biases the detection of epistatic interactions between driver mutations
Biswas D, Birkbak N, Herrero J, Swanton C. Abstract LB258: Branching cancer evolution biases the detection of epistatic interactions between driver mutations. Cancer Research 2021, 81: lb258-lb258. DOI: 10.1158/1538-7445.am2021-lb258.Peer-Reviewed Original ResearchDetection of epistatic interactionsEvolutionary dependenciesEpistatic interactionsCancer-typeCancer cell fractionDriver genesExome-sequencing dataCancer evolutionClonal mutationsCancer genomic datasetsTumor phylogenetic treePhylogenetic treeGenomic datasetsCancer genomesPan-cancer analysisMutation clonalityMissense mutationsMutation matrixClonal architectureGenesLife historyLung adenocarcinoma datasetSubclonal mutationsMutationsLung adenocarcinoma tumors