2024
In-Hospital Delirium and Disability and Cognitive Impairment After COVID-19 Hospitalization
Kaushik R, McAvay G, Murphy T, Acampora D, Araujo K, Charpentier P, Chattopadhyay S, Geda M, Gill T, Kaminski T, Lee S, Li J, Cohen A, Hajduk A, Ferrante L. In-Hospital Delirium and Disability and Cognitive Impairment After COVID-19 Hospitalization. JAMA Network Open 2024, 7: e2419640. PMID: 38954414, PMCID: PMC11220565, DOI: 10.1001/jamanetworkopen.2024.19640.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCognitive DysfunctionCOVID-19DeliriumFemaleHospitalizationHumansMaleMiddle AgedProspective StudiesSARS-CoV-2ConceptsIn-hospital deliriumChart-Based Delirium Identification InstrumentOlder adultsFunctional disabilityCOVID-19 hospitalizationCognitive impairmentCohort studyAssociated with increased functional disabilityHospitalized older adultsIncreased functional disabilityAssociation of deliriumPostdischarge follow-upRisk of deliriumTertiary care systemFollow-upPresence of cognitive impairmentProspective cohort studyLogistic regression modelsOlder survivorsCare systemIncreasing cognitive impairmentMain OutcomesCOVID-19Hospital dischargePrimary outcomeAssociations of Social Support With Physical and Mental Health Symptom Burden After COVID-19 Hospitalization Among Older Adults
Lee S, McAvay G, Geda M, Chattopadhyay S, Acampora D, Araujo K, Charpentier P, Gill T, Hajduk A, Cohen A, Ferrante L. Associations of Social Support With Physical and Mental Health Symptom Burden After COVID-19 Hospitalization Among Older Adults. The Journals Of Gerontology Series A 2024, 79: glae092. PMID: 38558166, PMCID: PMC11059296, DOI: 10.1093/gerona/glae092.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCOVID-19FemaleHospitalizationHumansMaleMental HealthMiddle AgedProspective StudiesSARS-CoV-2Social SupportConceptsLow social supportMental health symptomsSocial supportSymptom burdenHealth symptomsFollow-up assessmentCOVID-19 hospitalizationMedical Outcomes Study Social Support SurveyPhysical symptomsAssociation of social supportEdmonton Symptom Assessment SystemPatient Health Questionnaire-4Burden of physical symptomsMental health symptom burdenModified Edmonton Symptom Assessment SystemSocial Support SurveyParticipants' mean ageAssociated with higher burdenSupport SurveyOlder survivorsSymptom managementOlder AdultsMental healthHispanic ethnicityLongitudinal associations
2016
Effect of Cranberry Capsules on Bacteriuria Plus Pyuria Among Older Women in Nursing Homes: A Randomized Clinical Trial
Juthani-Mehta M, Van Ness PH, Bianco L, Rink A, Rubeck S, Ginter S, Argraves S, Charpentier P, Acampora D, Trentalange M, Quagliarello V, Peduzzi P. Effect of Cranberry Capsules on Bacteriuria Plus Pyuria Among Older Women in Nursing Homes: A Randomized Clinical Trial. JAMA 2016, 316: 1879-1887. PMID: 27787564, PMCID: PMC5300771, DOI: 10.1001/jama.2016.16141.Peer-Reviewed Original ResearchConceptsUrinary tract infectionPresence of bacteriuriaSymptomatic urinary tract infectionCranberry capsulesNursing homesOlder womenTreatment groupsControl groupPlacebo-controlled efficacy trialSignificant differencesRate of deathAntibiotic-resistant organismsControl group participantsCause deathStudy surveillanceCause hospitalizationSecondary outcomesTract infectionsPrimary outcomeOverall adherenceAntimicrobial utilizationClinical trialsEfficacy trialsPyuriaUnadjusted results
2007
A Randomized Trial of a Physical Conditioning Program to Enhance the Driving Performance of Older Persons
Marottoli RA, Allore H, Araujo KL, Iannone LP, Acampora D, Gottschalk M, Charpentier P, Kasl S, Peduzzi P. A Randomized Trial of a Physical Conditioning Program to Enhance the Driving Performance of Older Persons. Journal Of General Internal Medicine 2007, 22: 590-597. PMID: 17443366, PMCID: PMC1852916, DOI: 10.1007/s11606-007-0134-3.Peer-Reviewed Original ResearchMeSH KeywordsAccidents, TrafficAge FactorsAgedAged, 80 and overAutomobile DrivingExerciseFemaleHumansMalePsychomotor PerformanceConceptsOlder driversRoad test scoreDriving performanceControl participantsPotential safety implicationsIntervention driversTest scoresDrivers increasesCognitive impairmentCritical errorsOverall ratingDriving maneuversTraffic situationsCommunity sourcesSpeed of movementParticipantsPositive toneRatingsPhysical conditioning programRoad performanceInterventionOlder personsSafety moduleConditioning programSafety implications
1999
Home-based multicomponent rehabilitation program for older persons after hip fracture: A randomized trial
Tinetti M, Baker D, Gottschalk M, Williams C, Pollack D, Garrett P, Gill T, Marottoli R, Acampora D. Home-based multicomponent rehabilitation program for older persons after hip fracture: A randomized trial. Archives Of Physical Medicine And Rehabilitation 1999, 80: 916-922. PMID: 10453768, DOI: 10.1016/s0003-9993(99)90083-7.Peer-Reviewed Original ResearchConceptsMulticomponent rehabilitation programUsual careHip fractureRehabilitation programExtremity strengthOlder personsBetter gait performanceSelf-care ADLDaily living (ADL) disabilityDuration of rehabilitationOptimal functional recoveryProportion of participantsRehabilitation strategiesLower extremity strengthUpper extremity strengthYears of ageHome-based rehabilitationSocial activity levelsHome care servicesPrefracture levelSurgical repairFunctional recoveryImproved outcomesGait performanceHome care agenciesA Multicomponent Intervention to Prevent Delirium in Hospitalized Older Patients
Inouye S, Bogardus S, Charpentier P, Leo-Summers L, Acampora D, Holford T, Cooney L. A Multicomponent Intervention to Prevent Delirium in Hospitalized Older Patients. New England Journal Of Medicine 1999, 340: 669-676. PMID: 10053175, DOI: 10.1056/nejm199903043400901.Peer-Reviewed Original ResearchConceptsSeverity of deliriumRisk factorsCognitive impairmentRecurrence rateIntervention groupRisk factor intervention strategyHearing impairmentVisual impairmentHospitalized Older PatientsPatients 70 yearsPrevention of deliriumUsual care unitsUsual care groupGeneral medicine serviceEffective treatment strategiesDuration of episodesPrevent DeliriumOlder patientsRate of usePrimary outcomeSleep medicationPoor outcomePrimary preventionPatient's deliriumTeaching hospital
1993
A Controlled Trial of a Nursing‐Centered Intervention in Hospitalized Elderly Medical Patients: The Yale Geriatric Care Program
Inouye S, Wagner D, Acampora D, Horwitz R, Cooney L, Tinetii M. A Controlled Trial of a Nursing‐Centered Intervention in Hospitalized Elderly Medical Patients: The Yale Geriatric Care Program. Journal Of The American Geriatrics Society 1993, 41: 1353-1360. PMID: 8227919, DOI: 10.1111/j.1532-5415.1993.tb06487.x.Peer-Reviewed Original ResearchConceptsElderly medical patientsFunctional declineMedical patientsBeneficial effectsIntervention groupRelative riskHospitalized elderly medical patientsGeriatric care teamsFrail older patientsProspective cohort studyGeneral medicine wardsUniversity Teaching HospitalGeriatric care programSignificant beneficial effectIntervention patientsADL scoresCohort studyOlder patientsMedicine wardsControl subjectsHospital costsCare teamTeaching hospitalPhysical therapyStratified analysisA predictive index for functional decline in hospitalized elderly medical patients
Inouye S, Wagner D, Acampora D, Horwitz R, Cooney L, Hurst L, Tinetti M. A predictive index for functional decline in hospitalized elderly medical patients. Journal Of General Internal Medicine 1993, 8: 645-652. PMID: 8120679, DOI: 10.1007/bf02598279.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAgedAged, 80 and overChi-Square DistributionCohort StudiesConnecticutFemaleGeriatric AssessmentHospital Bed Capacity, 500 and overHospitals, UniversityHumansLikelihood FunctionsMaleMultivariate AnalysisPrevalenceProportional Hazards ModelsProspective StudiesReproducibility of ResultsRisk FactorsSingle-Blind MethodConceptsFunctional declineRisk factorsMedical patientsValidation cohortDevelopment cohortHospitalized elderly medical patientsIndependent baseline risk factorsLow social activity levelNumber of RFsPredictive indexBaseline risk factorsGeneral medical wardsProspective cohort studyGeneral medical patientsHigh-risk groupUniversity Teaching HospitalElderly medical patientsRisk stratification systemNursing home placementRate of deathSocial activity levelsComparable patientsCohort studyElderly patientsMedical wardsPredictors of Formal Home Health Care Use in Elderly Patients after Hospitalization
Solomon D, Wagner D, Marenberg M, Acampora D, Cooney L, Inouye S. Predictors of Formal Home Health Care Use in Elderly Patients after Hospitalization. Journal Of The American Geriatrics Society 1993, 41: 961-966. PMID: 8409182, DOI: 10.1111/j.1532-5415.1993.tb06762.x.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAge FactorsAgedAged, 80 and overComorbidityConfidence IntervalsEducational StatusFemaleForecastingGeriatric AssessmentHealth PlanningHealth Services ResearchHome Care ServicesHospitalizationHumansMalePatient DischargePatient ReadmissionProportional Hazards ModelsProspective StudiesRisk FactorsSeverity of Illness IndexSocial SupportConceptsHome health care useHealth care useRisk factorsAcute careElderly patientsSurgical patientsCare useHHC useProspective cohort studyRisk factor presentUniversity Teaching HospitalCohort studyHospital dischargeMedian durationIndependent predictorsSurgical wardsRisk strataDischarge planningTeaching hospitalInstrumental activitiesDaily livingElderly populationHHC agenciesStudy catchment areaPatients