2024
Raphe and ventrolateral medulla proteomics in sudden unexplained death in childhood with febrile seizure history
Leitner D, William C, Faustin A, Kanshin E, Snuderl M, McGuone D, Wisniewski T, Ueberheide B, Gould L, Devinsky O. Raphe and ventrolateral medulla proteomics in sudden unexplained death in childhood with febrile seizure history. Acta Neuropathologica 2024, 148: 76. PMID: 39607506, PMCID: PMC11604820, DOI: 10.1007/s00401-024-02832-9.Peer-Reviewed Original ResearchConceptsMedullary rapheSudden infant death syndromeVentrolateral medullaFebrile seizuresSudden unexplained deathWeighted gene correlation network analysisDorsal rapheUnexplained deathMidbrain dorsal rapheSUDC casesSignaling pathwayEukaryotic translation initiationGene Ontology biological processesSynaptic vesicle cycleLabel-free quantitative mass spectrometryEukaryotic translation elongationSudden unexpected deathGene correlation network analysisDifferential expression analysisDecreased cellular respirationFebrile seizure historyQuantitative mass spectrometryAutonomic dysfunctionCorrelation network analysisCoagulation system
2021
Blinded review of hippocampal neuropathology in sudden unexplained death in childhood reveals inconsistent observations and similarities to explained paediatric deaths
Leitner DF, McGuone D, William C, Faustin A, Askenazi M, Snuderl M, Guzzetta M, Jarrell HS, Maloney K, Reichard R, Smith C, Weedn V, Wisniewski T, Gould L, Devinsky O. Blinded review of hippocampal neuropathology in sudden unexplained death in childhood reveals inconsistent observations and similarities to explained paediatric deaths. Neuropathology And Applied Neurobiology 2021, 48: e12746. PMID: 34164845, PMCID: PMC8777468, DOI: 10.1111/nan.12746.Peer-Reviewed Original ResearchConceptsCause of deathSudden unexplained deathHippocampal findingsUnexplained deathBlinded reviewersFebrile seizure historyGranule cell lossForensic pathologistsBoard-certified forensic pathologistsHippocampal histologyHippocampal maldevelopmentFebrile seizuresHippocampal neuropathologyHippocampal sectionsPyramidal neuronsSeizure historyPediatric deathsChildhood casesSudden deathImmunohistological markersBlinded reviewNormal rangeCell lossLarger studySUDC
2020
Neuropathologic Changes in Sudden Unexplained Death in Childhood
McGuone D, Leitner D, William C, Faustin A, Leelatian N, Reichard R, Shepherd TM, Snuderl M, Crandall L, Wisniewski T, Devinsky O. Neuropathologic Changes in Sudden Unexplained Death in Childhood. Journal Of Neuropathology & Experimental Neurology 2020, 79: 336-346. PMID: 31995186, PMCID: PMC7036658, DOI: 10.1093/jnen/nlz136.Peer-Reviewed Original ResearchConceptsSudden unexplained deathHippocampal abnormalitiesUnexplained deathHippocampal findingsNumber of seizuresBoard-certified neuropathologistsCause of deathComprehensive case investigationMultiple chromosomal aberrationsSeizure pathogenesisSUDC casesFebrile seizuresHippocampal alterationsMedian ageHistological reviewNeuropathologic changesNeuropathologic investigationDentate gyrusProne positionCommon findingAncillary testingAutopsy dataMolecular testingApparent sleepBrain samples
2017
Neuropathologic Examination in Sudden Unexpected Deaths in Infancy and Childhood: Recommendations for Highest Diagnostic Yield and Cost-Effectiveness in Forensic Settings
Folkerth RD, Nunez J, Georgievskaya Z, McGuone D. Neuropathologic Examination in Sudden Unexpected Deaths in Infancy and Childhood: Recommendations for Highest Diagnostic Yield and Cost-Effectiveness in Forensic Settings. Academic Forensic Pathology 2017, 7: 182-199. PMID: 31239973, PMCID: PMC6474536, DOI: 10.23907/2017.020.Peer-Reviewed Original ResearchManner of deathCraniospinal traumaDural venous sinus thrombosisHypoxic-ischemic lesionsVenous sinus thrombosisSudden unexpected deathEvidence-based guidelinesHigh diagnostic yieldDandy-Walker malformationSix-month intervalsBrainstem gliosisBrainstem necrosisPeripartum asphyxiaSystemic sepsisSinus thrombosisNeuropathologic examinationFebrile seizuresNeuropathological findingsCerebral cortexComplete autopsyUnexpected deathDiagnostic yieldBilateral hippocampusHippocampal dysgenesisNormal brain