2005
Haplotype analysis of the SDF-1 (CXCL12) gene in a longitudinal HIV-1/AIDS cohort study
Modi W, Scott K, Goedert J, Vlahov D, Buchbinder S, Detels R, Donfield S, O'Brien S, Winkler C. Haplotype analysis of the SDF-1 (CXCL12) gene in a longitudinal HIV-1/AIDS cohort study. Genes & Immunity 2005, 6: 691-698. PMID: 16177829, DOI: 10.1038/sj.gene.6364258.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAdolescentAdultAllelesBlack or African AmericanChemokine CXCL12Chemokines, CXCChildCohort StudiesDisease ProgressionFemaleGene FrequencyHaplotypesHIV InfectionsHIV-1HumansLongitudinal StudiesMaleOdds RatioPolymorphism, Single NucleotideRisk FactorsSurvival AnalysisUnited StatesWhite PeopleConceptsSDF-1 geneCohort studySingle nucleotide polymorphismsAfrican AmericansOnly natural ligandSingle disease outcomesX4 HIV-1HIV-1 infectionAIDS Cohort StudyRisk of infectionMACS cohortDisease outcomeHIV-1Epidemiological studiesSDF-1Significant associationChemokine genesInfectionRs1801157Natural ligandProgressionHaplotype analysisCommon haplotypeCXCR4CohortSuicidal ideation among African-American non-injection drug users.
Havens J, Ompad D, Latkin C, Fuller C, Arria A, Vlahov D, Strathdee S. Suicidal ideation among African-American non-injection drug users. Ethnicity & Disease 2005, 15: 110-5. PMID: 15720057.Peer-Reviewed Original ResearchConceptsSuicidal ideationDrug usersDrug dependenceNon-injection drug usersCommunity-based cohortInterview-administered questionnaireMultiple logistic regressionDrug use historyUse of heroinAfrican American drug usersMedian agePsychiatric comorbidityDepressive symptomsMore drugsSuicidal thoughtsLogistic regressionIdeationAfrican AmericansUse historyParticipantsComorbiditiesCohortSymptomsYearsHeroin
2003
Genetic influence of CXCR6 chemokine receptor alleles on PCP-mediated AIDS progression among African Americans
Duggal P, An P, Beaty T, Strathdee S, Farzadegan H, Markham R, Johnson L, O'Brien S, Vlahov D, Winkler C. Genetic influence of CXCR6 chemokine receptor alleles on PCP-mediated AIDS progression among African Americans. Genes & Immunity 2003, 4: 245-250. PMID: 12761559, DOI: 10.1038/sj.gene.6363950.Peer-Reviewed Original ResearchConceptsPneumocystis carinii pneumoniaLate-stage HIV-1 infectionAfrican AmericansHIV-1 infectionMedian survival timeSIV infectionCarinii pneumoniaChemokine receptorsAIDS progressionPrimary coreceptorSurvival timeK polymorphismInitial infectionCXCR6Receptor allelesInfectionProgressionSingle nucleotide polymorphismsDeathK genotypesAIDSCoreceptorNucleotide polymorphismsGenetic influencesAllele frequencies
2002
#44 Changing racial/ethnic disparities in homicide mortality in nyc 1990–98 The role of drugs
Galea S, Tardiff K, Ahern J, Leon A, Vlahov D. #44 Changing racial/ethnic disparities in homicide mortality in nyc 1990–98 The role of drugs. Annals Of Epidemiology 2002, 12: 505-506. DOI: 10.1016/s1047-2797(02)00332-0.Peer-Reviewed Original ResearchPositive toxicologyHomicide decedentsAfrican AmericansEthnic disparitiesProportion of decedentsRole of drugsMedical examiner recordsNew York CityHispanic decedentsPositive cocaineHomicide mortalityAnnual ageMortality rateEthnic groupsStandardized ratesDecedentsNYC OfficeMortalityHomicide deathsHomicide mortality ratesSignificant decreaseAlcohol toxicologyOverall homicide ratesDrugsHispanicsRegional variation in CCR5-Δ32 gene distribution among women from the US HIV Epidemiology Research Study (HERS)
Downer M, Hodge T, Smith D, Qari S, Schuman P, Mayer K, Klein R, Vlahov D, Gardner L, McNicholl J. Regional variation in CCR5-Δ32 gene distribution among women from the US HIV Epidemiology Research Study (HERS). Genes & Immunity 2002, 3: 295-298. PMID: 12140749, DOI: 10.1038/sj.gene.6363884.Peer-Reviewed Original ResearchConceptsHIV Epidemiology Research StudyRace/ethnicityHIV-1HIV Epidemiologic Research StudyAfrican AmericansCCR5-Δ32 genotypeHIV-1 transmissionEpidemiologic research studiesHost genetic factorsHispanic/LatinaBlack/African AmericanUninfected womenAA womenUS womenCCR5-Δ32US populationWhite womenFrequency of heterozygotesWomenGenetic factorsDistributions of heterozygotesRegional variationResearch studiesHigh-risk behaviors associated with transition from illicit non-injection to injection drug use among adolescent and young adult drug users: a case-control study
Fuller C, Vlahov D, Ompad D, Shah N, Arria A, Strathdee S. High-risk behaviors associated with transition from illicit non-injection to injection drug use among adolescent and young adult drug users: a case-control study. Drug And Alcohol Dependence 2002, 66: 189-198. PMID: 11906806, DOI: 10.1016/s0376-8716(01)00200-9.Peer-Reviewed Original ResearchConceptsInjection drug usersInjection drug useAge-matched case-control analysisDrug usersDrug useBlood-borne infectionsAge-matched personsCase-control studyConditional logistic regressionCase-control analysisHigh-risk behaviorsNon-injection heroinCharacteristics of personsHIV seroprevalenceCohort studyInjection useAdult drug usersLogistic regressionPrevention effortsSame calendar timeYoung adult drug usersCalendar timePrior yearAfrican AmericansBaseline
2001
Impact of Needle Exchange Programs on Adolescent Perceptions About Illicit Drug Use
Marx M, Brahmbhatt H, Beilenson P, Brookmeyer R, Strathdee S, Alexander C, Vlahov D. Impact of Needle Exchange Programs on Adolescent Perceptions About Illicit Drug Use. AIDS And Behavior 2001, 5: 379-386. DOI: 10.1023/a:1013195108756.Peer-Reviewed Original ResearchFactors Associated with Adolescent Initiation of Injection Drug Use
Fuller C, Vlahov D, Arria A, Ompad D, Garfein R, Strathdee S. Factors Associated with Adolescent Initiation of Injection Drug Use. Public Health Reports 2001, 116: 136-145. PMID: 11889281, PMCID: PMC1913680, DOI: 10.1093/phr/116.s1.136.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdolescent BehaviorAdultAge FactorsBaltimoreBlack or African AmericanCommunity-Institutional RelationsFemaleHealth BehaviorHepatitis CHIV InfectionsHumansLogistic ModelsMalePrimary PreventionProspective StudiesRisk AssessmentRisk-TakingSexual BehaviorSubstance Abuse, IntravenousConceptsInjection drug useDrug useMedian ageInitiation of injectionCrack smokingNon-injection drug useAdolescent initiationHigh-risk groupYears of ageIllicit drug useAfrican AmericansDrug use practicesStudy enrollmentPrevents onsetEarly prevention effortsDrug usersMultivariate analysisCocaine useCondom useSmoking marijuanaLogistic regressionYoung drug usersPrevention effortsYoung adulthoodSmoking
2000
Influence of CCR5 promoter haplotypes on AIDS progression in African–Americans
An P, Martin M, Nelson G, Carrington M, Smith M, Gong K, Vlahov D, O'Brien S, Winkler C. Influence of CCR5 promoter haplotypes on AIDS progression in African–Americans. AIDS 2000, 14: 2117-2122. PMID: 11061652, DOI: 10.1097/00002030-200009290-00007.Peer-Reviewed Original ResearchConceptsCCR5 promoter haplotypesAIDS progressionSurvival analysisAfrican AmericansNatural history cohort studyPromoter haplotypesRate of progressionPromoter variantsCohort studyCCR5 alleleRapid progressionCaucasian cohortProgressionCaucasiansComplete linkage disequilibriumCCR2AIDSUnidentified polymorphismsRacial groupsLinkage disequilibriumSeroconvertersCCR5CohortHaplotypesCorrelates of enrollment in methadone maintenance treatment programs differ by HIV-serostatus
Shah N, Celentano D, Vlahov D, Stambolis V, Johnson L, Nelson K, Strathdee S. Correlates of enrollment in methadone maintenance treatment programs differ by HIV-serostatus. AIDS 2000, 14: 2035-2043. PMID: 10997409, DOI: 10.1097/00002030-200009080-00020.Peer-Reviewed Original ResearchMeSH KeywordsAdultBaltimoreCohort StudiesFemaleHealth Services AccessibilityHIV AntibodiesHIV InfectionsHIV SeronegativityHIV SeropositivityHumansMaleMethadoneMiddle AgedNeedle-Exchange ProgramsProspective StudiesRisk-TakingSocioeconomic FactorsSubstance Abuse Treatment CentersSubstance Abuse, IntravenousConceptsMethadone maintenance treatment programInjection drug usersMaintenance treatment programNeedle exchange programsHIV serostatusHIV-seronegative injection drug usersSeronegative injection drug usersHIV-negative injection drug usersTreatment programHIV-seropositive participantsHealth care providersTreatment slotsNeedle exchange program participantsAfrican AmericansHIV testProspective cohortCare providersDrug usersProgram attendanceOlder ageCertain subgroupsVulnerable populationsSimilar proportionsBehavioral factorsEnrollment
1997
Contrasting Genetic Influence of CCR2 and CCR5 Variants on HIV-1 Infection and Disease Progression
Smith M, Dean M, Carrington M, Winkler C, Huttley G, Lomb D, Goedert J, O'Brien T, Jacobson L, Kaslow R, Buchbinder S, Vittinghoff E, Vlahov D, Hoots K, Hilgartner M, Study H, San Francisco City Cohort ALIVE Study M, O'Brien S. Contrasting Genetic Influence of CCR2 and CCR5 Variants on HIV-1 Infection and Disease Progression. Science 1997, 277: 959-965. PMID: 9252328, DOI: 10.1126/science.277.5328.959.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeBlack PeopleCohort StudiesDisease ProgressionGenotypeHaplotypesHeterozygoteHIV InfectionsHIV-1HumansMutationPolymerase Chain ReactionPolymorphism, Restriction Fragment LengthPolymorphism, Single-Stranded ConformationalProportional Hazards ModelsReceptors, CCR2Receptors, CCR5Receptors, ChemokineReceptors, CytokineReceptors, HIVSurvival AnalysisWhite PeopleConceptsHIV-1 infectionCCR2-64IDisease progressionHIV-1 disease progressionHIV-1-infected individualsLong-term survivorsCCR2-64I alleleReceptor geneChemokine receptor genesAIDS 2CCR2 chemokineSyndrome cohortAIDS patientsCCR5-Delta32Human immunodeficiencyChemokine receptorsCCR5 variantsCCR2CCR5InfectionIndependent effectsAfrican AmericansMutant genotypesProgressionGenetic association analysis