2024
94. THE GENETIC ARCHITECTURE OF MOOD AND ANXIETY DISORDER SYMPTOMS
Schultz L, Mollon J, Jacquemont S, Almasy L, Glahn D. 94. THE GENETIC ARCHITECTURE OF MOOD AND ANXIETY DISORDER SYMPTOMS. European Neuropsychopharmacology 2024, 87: 100. DOI: 10.1016/j.euroneuro.2024.08.208.Peer-Reviewed Original ResearchEuropean ancestryPrefrontal cortexPsychiatric diagnosisGene set analysisAssociated with genesInverse-variance weighted meta-analysisICD-10 psychiatric diagnosisMeta-analysisAnxiety disorder symptomsUK Biobank (UKBMulti-ancestry meta-analysisGenome-wide significant variantsGenetic architectureRisk lociMSigDB geneChromosome 8Confirmatory factor modelsGenomic risk lociEuropean ancestry individualsAnxiety disordersDisorder symptomsMood/anxiety symptomsIdentified risk lociDopamine receptorsFrontal cortex
2016
Clinical Heterogeneity Arising from Categorical and Dimensional Features of the Neurobiology of Psychiatric Diagnoses
Krystal J, Anticevic A, Murray J, Glahn D, Driesen N, Yang G, Wang X. Clinical Heterogeneity Arising from Categorical and Dimensional Features of the Neurobiology of Psychiatric Diagnoses. 2016 DOI: 10.7551/mitpress/9780262035422.003.0016.Peer-Reviewed Original ResearchPsychiatric diagnosisDiagnostic schemaComputational neuroscience approachBiology of schizophreniaNeuroscience approachPsychiatric diagnosingAssociated with attemptsClinical heterogeneityPsychiatric genomicsSchizophreniaDSMCategorical featuresNeurobiologySchemaCurrent treatmentCluster patientsIllnessCategorizationTreatment