2022
Development and pilot testing of EHR-nudges to reduce overuse in older primary care patients
Rowe T, Brown T, Lee J, Linder J, Meeker D, Doctor J, Goldstein N, Fox C, Persell S. Development and pilot testing of EHR-nudges to reduce overuse in older primary care patients. Archives Of Gerontology And Geriatrics 2022, 104: 104794. PMID: 36115068, PMCID: PMC9682472, DOI: 10.1016/j.archger.2022.104794.Peer-Reviewed Original ResearchMeSH KeywordsAgedEarly Detection of CancerElectronic Health RecordsHumansMalePrimary Health CareProstate-Specific AntigenProstatic NeoplasmsConceptsProstate-specific antigenUA/UCCDS alertsOlder adultsCommon conditionUnnecessary testingOlder primary care patientsClinical decision support alertsNon-specific reasonsOral hypoglycemic medicationsOvertreatment of diabetesPrimary care patientsPrimary care physiciansLarge health systemDecision support alertsHypoglycemic medicationsOveruse measuresCare patientsCare physiciansSignificant morbidityUrine cultureProstate cancerAmbulatory careClinical actionsAdult menThe protocol of improving safe antibiotic prescribing in telehealth: A randomized trial
McCabe B, Linder J, Doctor J, Friedberg M, Fox C, Goldstein N, Knight T, Kaiser K, Tibbels J, Haenchen S, Persell S, Warberg R, Meeker D. The protocol of improving safe antibiotic prescribing in telehealth: A randomized trial. Contemporary Clinical Trials 2022, 119: 106834. PMID: 35724841, DOI: 10.1016/j.cct.2022.106834.Peer-Reviewed Original ResearchConceptsAcute respiratory infectionsInappropriate antibiotic prescribingAntibiotic prescribing ratesAntibiotic prescribingPrescribing ratesRandomized quality improvement trialAntibiotic stewardship interventionsInappropriate antibiotic prescriptionsUrgent care visitsPrevious randomized trialsPrimary care clinicsQuality improvement trialEffective antibiotic useElectronic health recordsARI visitsInappropriate prescribingAntibiotic prescriptionsCare visitsSecondary outcomesPrimary outcomeRespiratory infectionsCare clinicsRandomized trialsStewardship interventionsAntibiotic useExtracting Patient-level Social Determinants of Health into the OMOP Common Data Model.
Phuong J, Zampino E, Dobbins N, Espinoza J, Meeker D, Spratt H, Madlock-Brown C, Weiskopf N, Wilcox A. Extracting Patient-level Social Determinants of Health into the OMOP Common Data Model. AMIA Annual Symposium Proceedings 2022, 2021: 989-998. PMID: 35308947, PMCID: PMC8861735.Peer-Reviewed Original ResearchMeSH KeywordsCOVID-19Electronic Health RecordsHumansMass ScreeningSocial Determinants of HealthSurveys and QuestionnairesDevelopment of High-Risk Geriatric Polypharmacy Electronic Clinical Quality Measures and a Pilot Test of EHR Nudges Based on These Measures
Persell S, Brown T, Doctor J, Fox C, Goldstein N, Handler S, Hanlon J, Lee J, Linder J, Meeker D, Rowe T, Sullivan M, Friedberg M. Development of High-Risk Geriatric Polypharmacy Electronic Clinical Quality Measures and a Pilot Test of EHR Nudges Based on These Measures. Journal Of General Internal Medicine 2022, 37: 2777-2785. PMID: 34993860, PMCID: PMC9411452, DOI: 10.1007/s11606-021-07296-1.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnti-Inflammatory Agents, Non-SteroidalElectronic Health RecordsElectronicsHumansInappropriate PrescribingPolypharmacyQuality Indicators, Health CareConceptsHigh-risk criteriaNon-dihydropyridine calcium channel blockersMore high-risk criteriaSingle large health systemThree-arm pilotChronic kidney diseaseHigh-risk medicationsCalcium channel blockersLarge health systemDrug-drug interactionsClinical quality measuresElectronic health recordsEHR alertMain MeasuresRatesMore medicationsPatients 65Older patientsHeart failureKey ResultsAmongKidney diseaseNovel electronic health recordPolypharmacyChannel blockersFall historyPatients
2021
Design of Behavioral Economic Applications to Geriatrics Leveraging Electronic Health Records (BEAGLE): A pragmatic cluster randomized controlled trial
Brown T, Rowe T, Lee J, Petito L, Chmiel R, Ciolino J, Doctor J, Fox C, Goldstein N, Kaiser D, Linder J, Meeker D, Peprah Y, Persell S. Design of Behavioral Economic Applications to Geriatrics Leveraging Electronic Health Records (BEAGLE): A pragmatic cluster randomized controlled trial. Contemporary Clinical Trials 2021, 112: 106649. PMID: 34896294, PMCID: PMC8724916, DOI: 10.1016/j.cct.2021.106649.Peer-Reviewed Original ResearchMeSH KeywordsAgedDecision Support Systems, ClinicalDiabetes MellitusEconomics, BehavioralElectronic Health RecordsFemaleGeriatricsHumansMaleConceptsPrimary care clinicsProstate-specific antigenCo-primary outcomesElectronic health recordsCare clinicsOlder adultsClinician educationParallel armsPragmatic cluster-randomized trialNon-specific reasonsOvertreatment of diabetesClinical decision support interventionHealth recordsPrimary care cliniciansChoosing Wisely campaignLarge regional health systemCluster-randomized trialDecision support interventionsPragmatic clusterRegional health systemOlder patientsStudy armsCare cliniciansDiabetes measuresUrine testingPrivacy-protecting, reliable response data discovery using COVID-19 patient observations
Kim J, Neumann L, Paul P, Day M, Aratow M, Bell D, Doctor J, Hinske L, Jiang X, Kim K, Matheny M, Meeker D, Pletcher M, Schilling L, SooHoo S, Xu H, Zheng K, Ohno-Machado L, Anderson D, Anderson N, Balacha C, Bath T, Baxter S, Becker-Pennrich A, Bernstam E, Carter W, Chau N, Choi Y, Covington S, DuVall S, El-Kareh R, Florian R, Follett R, Geisler B, Ghigi A, Gottlieb A, Hu Z, Ir D, Knight T, Koola J, Kuo T, Lee N, Mansmann U, Mou Z, Murphy R, Neumann L, Nguyen N, Niedermayer S, Park E, Perkins A, Post K, Rieder C, Scherer C, Soares A, Soysal E, Tep B, Toy B, Wang B, Wu Z, Zhou Y, Zucker R. Privacy-protecting, reliable response data discovery using COVID-19 patient observations. Journal Of The American Medical Informatics Association 2021, 28: 1765-1776. PMID: 34051088, PMCID: PMC8194878, DOI: 10.1093/jamia/ocab054.Peer-Reviewed Original ResearchThe protocol of the Application of Economics & Social psychology to improve Opioid Prescribing Safety Trial 1 (AESOPS-1): Electronic health record nudges
Kelley M, Persell S, Linder J, Friedberg M, Meeker D, Fox C, Goldstein N, Knight T, Zein D, Rowe T, Sullivan M, Doctor J. The protocol of the Application of Economics & Social psychology to improve Opioid Prescribing Safety Trial 1 (AESOPS-1): Electronic health record nudges. Contemporary Clinical Trials 2021, 103: 106329. PMID: 33636344, PMCID: PMC8089040, DOI: 10.1016/j.cct.2021.106329.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidElectronic Health RecordsHumansOpioid-Related DisordersPractice Patterns, Physicians'Psychology, SocialRandomized Controlled Trials as TopicConceptsEHR-based interventionsElectronic health recordsPrimary careLong-term opioid useHigh-risk prescriptionsProportion of patientsPrimary care clinicsTrial 1Mixed-effects regression modelsPersistence of effectsDaily MMEMorphine equivalentsNoncancer painLack of evidenceOpioid prescribingOpioid useSecondary outcomesDaily dosePrimary outcomeCare clinicsIntervention armPrescribing SafetyClinical guidelinesControl armIntervention period
2017
Effects of Behavioral Interventions on Inappropriate Antibiotic Prescribing in Primary Care 12 Months After Stopping Interventions
Linder J, Meeker D, Fox C, Friedberg M, Persell S, Goldstein N, Doctor J. Effects of Behavioral Interventions on Inappropriate Antibiotic Prescribing in Primary Care 12 Months After Stopping Interventions. JAMA 2017, 318: 1391-1392. PMID: 29049577, PMCID: PMC5818848, DOI: 10.1001/jama.2017.11152.Peer-Reviewed Original Research
2016
Characterizing treatment pathways at scale using the OHDSI network
Hripcsak G, Ryan P, Duke J, Shah N, Park R, Huser V, Suchard M, Schuemie M, DeFalco F, Perotte A, Banda J, Reich C, Schilling L, Matheny M, Meeker D, Pratt N, Madigan D. Characterizing treatment pathways at scale using the OHDSI network. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: 7329-7336. PMID: 27274072, PMCID: PMC4941483, DOI: 10.1073/pnas.1510502113.Peer-Reviewed Original ResearchConceptsAdministrative claims dataTreatment pathwaysClaims dataType 2 diabetes mellitusFirst-line medicationElectronic health record dataClinical trial resultsObservational researchHealth record dataElectronic health recordsDiabetes mellitusHypertension patientsDepression patientsConsistent therapyObservational studyOHDSI networkObservational Health Data SciencesPatientsTrial resultsClinical hypothesisHealth recordsRecord dataSignificant heterogeneityHealth Data SciencesHypertensionCognitive reflection and antibiotic prescribing for acute respiratory infections
Pineros D, Doctor J, Friedberg M, Meeker D, Linder J. Cognitive reflection and antibiotic prescribing for acute respiratory infections. Family Practice 2016, 33: 309-311. PMID: 27006411, PMCID: PMC4931815, DOI: 10.1093/fampra/cmw015.Peer-Reviewed Original ResearchConceptsAcute respiratory infectionsAntibiotic prescribing ratesAntibiotic prescribingPrescribing ratesRespiratory infectionsCommon clinical decisionsPrescription of antibioticsElectronic health record dataPrimary care practicesHealth record dataCare practicesClinicians' tendenciesClinical decisionPrescribingRecord dataCliniciansInfectionAntibioticsHigher scoresScoresPsychological testsCareEffect of Behavioral Interventions on Inappropriate Antibiotic Prescribing Among Primary Care Practices: A Randomized Clinical Trial
Meeker D, Linder J, Fox C, Friedberg M, Persell S, Goldstein N, Knight T, Hay J, Doctor J. Effect of Behavioral Interventions on Inappropriate Antibiotic Prescribing Among Primary Care Practices: A Randomized Clinical Trial. JAMA 2016, 315: 562-570. PMID: 26864410, PMCID: PMC6689234, DOI: 10.1001/jama.2016.0275.Peer-Reviewed Original ResearchConceptsAcute respiratory tract infectionsInappropriate antibiotic prescribingAntibiotic prescribing ratesRespiratory tract infectionsPrimary care practicesAntibiotic prescribingPrescribing ratesTract infectionsAccountable justificationCare practicesBehavioral interventionsElectronic health recordsClinical trialsAntibiotic prescribing guidelinesElectronic order setsPatients' electronic health recordsAdult patientsPrescribing guidelinesAmbulatory visitsMonth 18Concomitant infectionNonantibiotic treatmentIntervention periodMonths preinterventionMAIN OUTCOME
2015
Evaluating the feasibility and utility of translating Choosing Wisely recommendations into e-Measures
Shetty K, Meeker D, Schneider E, Hussey P, Damberg C. Evaluating the feasibility and utility of translating Choosing Wisely recommendations into e-Measures. Healthcare 2015, 3: 24-37. PMID: 26179586, DOI: 10.1016/j.hjdsi.2014.12.002.Peer-Reviewed Original ResearchMeSH KeywordsDelivery of Health CareElectronic Health RecordsHumansInternal MedicineMedical Records Systems, ComputerizedUnited States
2014
Nudging Physician Prescription Decisions by Partitioning the Order Set: Results of a Vignette-Based Study
Tannenbaum D, Doctor J, Persell S, Friedberg M, Meeker D, Friesema E, Goldstein N, Linder J, Fox C. Nudging Physician Prescription Decisions by Partitioning the Order Set: Results of a Vignette-Based Study. Journal Of General Internal Medicine 2014, 30: 298-304. PMID: 25394536, PMCID: PMC4351289, DOI: 10.1007/s11606-014-3051-2.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedDecision Support Systems, ClinicalElectronic Health RecordsFemaleHumansMaleMiddle AgedPhysicians, Primary CarePrescriptionsSurveys and QuestionnairesConceptsEHR order setsPrimary care providersElectronic health recordsNarrow-spectrum antibioticsOrder setsTreatment menuTreatment choiceCare providersMain MeasuresThe main outcomeAggressive treatment optionsAcute respiratory infectionsPhysician prescription decisionsBroad-spectrum antibioticsRespiratory infectionsPrescribing practicesCounter medicationsTreatment optionsPrescription decisionsMAIN OUTCOMEPatient careTypical signsBackgroundHealthcare professionalsPrescription drugsProvider decisionsAggressive optionsUnderstanding data requirements of retrospective studies
Shenvi E, Meeker D, Boxwala A. Understanding data requirements of retrospective studies. International Journal Of Medical Informatics 2014, 84: 76-84. PMID: 25453276, PMCID: PMC6626658, DOI: 10.1016/j.ijmedinf.2014.10.004.Peer-Reviewed Original ResearchpSCANNER: patient-centered Scalable National Network for Effectiveness Research
Ohno-Machado L, Agha Z, Bell D, Dahm L, Day M, Doctor J, Gabriel D, Kahlon M, Kim K, Hogarth M, Matheny M, Meeker D, Nebeker J, team T, Resnic F, Khodyakov D, Armstead L, Nagler T, Morley S, Anderson N, Cooper D, Phillips D, Heber D, Li Z, Ong M, Patel A, Zachariah M, Burns J, Daniels L, Doan S, Farcas C, Germann-Kurtz R, Jiang X, Kim H, Paul P, Taras H, Tremoulet A, Wang S, Zhu W, Berman D, Rizk-Jackson A, D’Arcy M, Kesselman C, Knight T, Pearlman L, Heidenreich P, Rifkin D, Stepnowsky C, Zamora T, DuVall S, Frey L, Scehnet J, Sauer B, Facelli J, Gouripeddi R, Denton J, FitzHenry F, Fly J, Messina V, Minter F, Nookala L, Sullivan H, Speroff T, Westerman D. pSCANNER: patient-centered Scalable National Network for Effectiveness Research. Journal Of The American Medical Informatics Association 2014, 21: 621-626. PMID: 24780722, PMCID: PMC4078293, DOI: 10.1136/amiajnl-2014-002751.Peer-Reviewed Original ResearchConceptsInitial use caseCommon data modelPatient Centered Outcomes Research InstituteHealth information exchange dataComputing infrastructuresFederated networkUse casesDistributed systemData modelComputation modelExchange dataPatient-powered research networksCommunity-based outpatient clinicsNetworkCongestive heart failureOutcomes Research InstituteEffectiveness researchAsynchronous modeHealth services researchersKawasaki diseaseHeart failureOutpatient clinicVA InformaticsAmbulatory careNational network
2013
Use of behavioral economics and social psychology to improve treatment of acute respiratory infections (BEARI): rationale and design of a cluster randomized controlled trial [1RC4AG039115-01] - study protocol and baseline practice and provider characteristics
Persell S, Friedberg M, Meeker D, Linder J, Fox C, Goldstein N, Shah P, Knight T, Doctor J. Use of behavioral economics and social psychology to improve treatment of acute respiratory infections (BEARI): rationale and design of a cluster randomized controlled trial [1RC4AG039115-01] - study protocol and baseline practice and provider characteristics. BMC Infectious Diseases 2013, 13: 290. PMID: 23806017, PMCID: PMC3701464, DOI: 10.1186/1471-2334-13-290.Peer-Reviewed Original ResearchConceptsAcute respiratory infectionsInappropriate antibiotic prescribingAntibiotic prescribingInappropriate prescribingRespiratory infectionsComputerized clinical decision supportAntibiotic prescribing ratesTrial study protocolInappropriate antibiotic useAdverse drug eventsCost of careUnit of randomizationPatients' electronic health recordsElectronic health recordsPersistence of effectsARI diagnosesNonbacterial infectionsAntibiotic prescriptionsSecondary outcomesClinical decision supportPrescribing ratesPrimary outcomeBehavioral economic strategiesGuideline recommendationsYear follow