1990
Bovine papillomavirus E2 repressor mutant displays a high-copy-number phenotype and enhanced transforming activity
Riese D, Settleman J, Neary K, DiMaio D. Bovine papillomavirus E2 repressor mutant displays a high-copy-number phenotype and enhanced transforming activity. Journal Of Virology 1990, 64: 944-949. PMID: 2153255, PMCID: PMC249196, DOI: 10.1128/jvi.64.2.944-949.1990.Peer-Reviewed Original ResearchConceptsRepressor proteinWild-type copy numberBovine papillomavirus type 1 genomeCopy numberViral genomeTranscriptional repressor proteinTransient expression experimentsMouse C127 cellsMutant viral DNAViral DNAType 1 genomeNumber phenotypeRepressor activityLow copy numberMethionine codonInitiation codonExpression experimentsC127 cellsGenomeCV1 cellsRepressor mutantsFoci formationColony formationCodonProtein
1988
Bovine papillomavirus mutant temperature sensitive for transformation, replication and transactivation.
DiMaio D, Settleman J. Bovine papillomavirus mutant temperature sensitive for transformation, replication and transactivation. The EMBO Journal 1988, 7: 1197-1204. PMID: 2841117, PMCID: PMC454456, DOI: 10.1002/j.1460-2075.1988.tb02931.x.Peer-Reviewed Original ResearchConceptsMutant viral DNANormal viral DNA replicationMajor viral regulatory proteinLack of mutantsN-terminal halfTemperature-sensitive defectMouse C127 cellsViral DNA replicationViral regulatory proteinsStrong genetic evidenceViral DNAPleiotropic phenotypesGenetic experimentsMost cell linesDNA replicationGene activityGenetic evidenceReplication defectRegulatory proteinsExtrachromosomal plasmidsMutant temperatureC127 cellsTemperature shiftGenetic analysisViral biological activities
1986
Nonsense mutation in open reading frame E2 of bovine papillomavirus DNA
DiMaio D. Nonsense mutation in open reading frame E2 of bovine papillomavirus DNA. Journal Of Virology 1986, 57: 475-480. PMID: 3003380, PMCID: PMC252759, DOI: 10.1128/jvi.57.2.475-480.1986.Peer-Reviewed Original ResearchConceptsMutant viral DNAOpen reading frame E2C127 cellsBovine papillomavirus DNAViral DNAGenetic mapping experimentsNonsense mutationMouse C127 cellsSingle base substitution mutationsHost cell genomeFull-length viral DNAFocus-forming activityBase substitution mutationsWild-type DNAAmber mutationCell genomeOncogenic transformationViral ORFsSubstitution mutationsORF E2Mapping experimentsMutant DNATransformation assaysDNABovine papillomavirus