2019
Visualizing structure and transitions in high-dimensional biological data
Moon KR, van Dijk D, Wang Z, Gigante S, Burkhardt DB, Chen WS, Yim K, Elzen AVD, Hirn MJ, Coifman RR, Ivanova NB, Wolf G, Krishnaswamy S. Visualizing structure and transitions in high-dimensional biological data. Nature Biotechnology 2019, 37: 1482-1492. PMID: 31796933, PMCID: PMC7073148, DOI: 10.1038/s41587-019-0336-3.Peer-Reviewed Original ResearchConceptsSingle-cell RNA sequencing datasetsSingle-cell RNA sequencingUnique biological insightsRNA sequencing datasetsGerm layer differentiationMain developmental branchesHigh-throughput technologiesGut microbiome dataRNA sequencingUndescribed subpopulationsHigh-dimensional biological dataSequencing datasetsBiological insightsDevelopmental branches
2014
Quantitative Arbor Analytics: Unsupervised Harmonic Co-Clustering of Populations of Brain Cell Arbors Based on L-Measure
Lu Y, Carin L, Coifman R, Shain W, Roysam B. Quantitative Arbor Analytics: Unsupervised Harmonic Co-Clustering of Populations of Brain Cell Arbors Based on L-Measure. Neuroinformatics 2014, 13: 47-63. PMID: 25086878, DOI: 10.1007/s12021-014-9237-2.Peer-Reviewed Original ResearchConceptsCo-clustering methodAnalytics systemSynthetic datasetsThree-dimensional visualizationAnalysis ToolkitHeterogeneous ensembleDistance measureAlgorithmMultivariate data pointsData smoothingData pointsWavelet basisData matrixHarmonic analysis theoryL-measureNeuroMorpho databaseDatasetAnalysis theoryToolkitVisualizationEnsembleRobustnessDatabaseSuperiorityMethod
2009
Chemical modifier screen identifies HDAC inhibitors as suppressors of PKD models
Cao Y, Semanchik N, Lee SH, Somlo S, Barbano PE, Coifman R, Sun Z. Chemical modifier screen identifies HDAC inhibitors as suppressors of PKD models. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 21819-21824. PMID: 19966229, PMCID: PMC2799791, DOI: 10.1073/pnas.0911987106.Peer-Reviewed Original ResearchConceptsKidney cyst formationCommon human genetic diseasesLarge-scale high-throughput screensHDAC inhibitorsBody curvatureChemical modifier screensHuman genetic diseasesPolycystic kidney diseaseHigh-throughput screenModifier screenSpecific HDAC inhibitorsCyst formationClass I HDACsCausal genesKnockdown animalsCiliary signalsPKD pathogenesisPan-HDAC inhibitorsPKD modelLaterality defectsGenetic diseasesPKD treatmentZebrafishAutosomal dominant polycystic kidney diseaseDrug candidates