2024
Structural neural plasticity evoked by rapid-acting antidepressant interventions
Liao C, Dua A, Wojtasiewicz C, Liston C, Kwan A. Structural neural plasticity evoked by rapid-acting antidepressant interventions. Nature Reviews Neuroscience 2024, 1-14. PMID: 39558048, DOI: 10.1038/s41583-024-00876-0.Peer-Reviewed Original ResearchAntidepressant interventionsStructural neural plasticityNeural plasticityPsychoactive drugsRapid-acting antidepressant drugsAction of psychoactive drugsRepetitive transcranial magnetic stimulationExcitatory synaptic functionAntidepressant effectsPrefrontal cortexDepressive disorderNon-invasive neurostimulationAntidepressant drugsMood disordersNeurobiological actionsTranscranial magnetic stimulationElectroconvulsive therapyPsychedelic drugsCortical pyramidal neuronsMechanisms of plasticityLongitudinal effectsGrowth of dendritic spinesPyramidal neuronsStructural plasticitySynaptic function
2021
Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo
Shao LX, Liao C, Gregg I, Davoudian PA, Savalia NK, Delagarza K, Kwan AC. Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo. Neuron 2021, 109: 2535-2544.e4. PMID: 34228959, PMCID: PMC8376772, DOI: 10.1016/j.neuron.2021.06.008.Peer-Reviewed Original ResearchConceptsFrontal cortexDendritic spinesMouse medial frontal cortexLayer 5 pyramidal neuronsSpine formation ratesApical dendritic spinesMedial frontal cortexUntapped therapeutic potentialPyramidal neuronsSingle doseExcitatory neurotransmissionBehavioral deficitsBeneficial actionsStructural remodelingSynaptic rewiringMammalian brainTherapeutic potentialNeural adaptationUse of psychedelicsSerotonergic psychedelicsSpine sizeTwo-photon microscopyCortexPsilocybinSpine