Featured Publications
Unique inflammatory RNA profiles of microglia in Creutzfeldt–Jakob disease
Baker CA, Manuelidis L. Unique inflammatory RNA profiles of microglia in Creutzfeldt–Jakob disease. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 675-679. PMID: 12525699, PMCID: PMC141055, DOI: 10.1073/pnas.0237313100.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCells, CulturedCreutzfeldt-Jakob SyndromeGene Expression ProfilingInflammationInterferon-gammaLipopolysaccharidesMiceMicrogliaOligonucleotide Array Sequence AnalysisPrPSc ProteinsReverse Transcriptase Polymerase Chain ReactionConceptsCreutzfeldt-Jakob diseaseMyeloid cellsUninfected microgliaInflammatory pathwaysMicroglial cellsIFN-gammaInflammatory stimuliMicrogliaInflammatory genesProtein pathologyInfectious agentsPreclinical diagnosisNeurodegenerative diseasesTransmissible spongiformDiseaseBrainPrP amyloidRNA profilesExpression profilesCellsCDNA arraysPrevious studiesInfectionDiagnosisPathology
2004
New molecular markers of early and progressive CJD brain infection
Lu ZY, Baker CA, Manuelidis L. New molecular markers of early and progressive CJD brain infection. Journal Of Cellular Biochemistry 2004, 93: 644-652. PMID: 15660413, DOI: 10.1002/jcb.20220.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomarkersBrainCreutzfeldt-Jakob SyndromeEncephalitisImmunity, InnateMiceMyeloid CellsProtein BiosynthesisProteinsReverse Transcriptase Polymerase Chain ReactionRNA, MessengerTime FactorsTranscription, GeneticUp-RegulationConceptsCreutzfeldt-Jakob diseaseBrain infectionTransmissible spongiform encephalopathiesHuman Creutzfeldt-Jakob diseaseAccessible peripheral tissuesL-selectin mRNASerum amyloid A3Progressive diseaseInflammatory pathwaysMIP-1alphaMIP-1betaIntracerebral inoculationPeripheral tissuesEarly diagnosisTSE infectionInfectious componentNormal brainTSE strainsInfectious agentsMyeloid cellsSimilar sequential changesImmune systemMouse brainTSE agentsNew molecular markersEarly induction of interferon-responsive mRNAs in Creutzfeldt-Jakob disease
Baker CA, Lu ZY, Manuelidis L. Early induction of interferon-responsive mRNAs in Creutzfeldt-Jakob disease. Journal Of NeuroVirology 2004, 10: 29-40. PMID: 14982726, PMCID: PMC4624297, DOI: 10.1080/13550280490261761.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, WesternBrainCluster AnalysisCreutzfeldt-Jakob SyndromeDNA PrimersGene Expression RegulationInterferonsMiceMicrogliaPrPSc ProteinsReverse Transcriptase Polymerase Chain ReactionRNA, MessengerSignal TransductionTranscription FactorsUp-RegulationConceptsCreutzfeldt-Jakob diseaseCJD agentCJD brainsInterferon-sensitive genesImmune responseForeign infectious agentsHost immune responseAbnormal prion proteinHost defense mechanismsMicroglial responseInflammatory pathwaysClinical signsPure microgliaViral infectionInfectious agentsWhole brainImmune recognitionPersistent virusesInterferon responsePreclinical diagnosisInfectionEarly inductionBrainMicrogliaGene expression profiles