2002
Microglia from Creutzfeldt-Jakob Disease-Infected Brains Are Infectious and Show Specific mRNA Activation Profiles
Baker CA, Martin D, Manuelidis L. Microglia from Creutzfeldt-Jakob Disease-Infected Brains Are Infectious and Show Specific mRNA Activation Profiles. Journal Of Virology 2002, 76: 10905-10913. PMID: 12368333, PMCID: PMC136595, DOI: 10.1128/jvi.76.21.10905-10913.2002.Peer-Reviewed Original ResearchMeSH KeywordsAmyloid beta-PeptidesAnimalsAntigens, CDAntigens, Differentiation, MyelomonocyticBrainCD40 AntigensChemokine CXCL10Chemokines, CXCCreutzfeldt-Jakob SyndromeGene ExpressionGene Expression ProfilingInterleukin-1Leukocyte Common AntigensLipopolysaccharidesMiceMicrogliaReceptor, Macrophage Colony-Stimulating FactorReceptors, CCR5RNA, MessengerTumor Necrosis Factor-alphaConceptsCreutzfeldt-Jakob diseaseCJD agentInfectious agentsCJD-infected miceB lymphocyte chemoattractantCytokine interleukin-1betaResult of infectionPathological prion proteinBrain cell typesMicroglial studiesMicroglial changesMicroglial markersReverse transcription-PCRAntigen presentationInterleukin-1betaBrain homogenatesMicrogliaPrP levelsBacterial lipopolysaccharideCellular activationPathological PrPActivated cellsBovine spongiformSpongiform encephalopathiesMolecular pathways
1999
Microglial Activation Varies in Different Models of Creutzfeldt-Jakob Disease
Baker C, Lu Z, Zaitsev I, Manuelidis L. Microglial Activation Varies in Different Models of Creutzfeldt-Jakob Disease. Journal Of Virology 1999, 73: 5089-5097. PMID: 10233972, PMCID: PMC112554, DOI: 10.1128/jvi.73.6.5089-5097.1999.Peer-Reviewed Original ResearchConceptsCreutzfeldt-Jakob diseaseLysosomal protease cathepsin SCathepsin SMRNA expressionAbnormal PrP formationHost mRNA expressionUpregulation of CCR5Chemokine receptor CCR5Glial cell involvementGrowth factor beta1Microglial transcriptsNeuronal destructionProtease cathepsin SMicroglial activationAmyloid depositionPathogenetic pathwaysReceptor CCR5Cell involvementRodent modelsChronic reservoirDistinctive neuropathologyPleiotropic cytokineTGF-beta1Primary sitePrP pathology