2004
Early induction of interferon-responsive mRNAs in Creutzfeldt-Jakob disease
Baker CA, Lu ZY, Manuelidis L. Early induction of interferon-responsive mRNAs in Creutzfeldt-Jakob disease. Journal Of NeuroVirology 2004, 10: 29-40. PMID: 14982726, PMCID: PMC4624297, DOI: 10.1080/13550280490261761.Peer-Reviewed Original ResearchConceptsCreutzfeldt-Jakob diseaseCJD agentCJD brainsInterferon-sensitive genesImmune responseForeign infectious agentsHost immune responseAbnormal prion proteinHost defense mechanismsMicroglial responseInflammatory pathwaysClinical signsPure microgliaViral infectionInfectious agentsWhole brainImmune recognitionPersistent virusesInterferon responsePreclinical diagnosisInfectionEarly inductionBrainMicrogliaGene expression profiles
2002
Microglia from Creutzfeldt-Jakob Disease-Infected Brains Are Infectious and Show Specific mRNA Activation Profiles
Baker CA, Martin D, Manuelidis L. Microglia from Creutzfeldt-Jakob Disease-Infected Brains Are Infectious and Show Specific mRNA Activation Profiles. Journal Of Virology 2002, 76: 10905-10913. PMID: 12368333, PMCID: PMC136595, DOI: 10.1128/jvi.76.21.10905-10913.2002.Peer-Reviewed Original ResearchMeSH KeywordsAmyloid beta-PeptidesAnimalsAntigens, CDAntigens, Differentiation, MyelomonocyticBrainCD40 AntigensChemokine CXCL10Chemokines, CXCCreutzfeldt-Jakob SyndromeGene ExpressionGene Expression ProfilingInterleukin-1Leukocyte Common AntigensLipopolysaccharidesMiceMicrogliaReceptor, Macrophage Colony-Stimulating FactorReceptors, CCR5RNA, MessengerTumor Necrosis Factor-alphaConceptsCreutzfeldt-Jakob diseaseCJD agentInfectious agentsCJD-infected miceB lymphocyte chemoattractantCytokine interleukin-1betaResult of infectionPathological prion proteinBrain cell typesMicroglial studiesMicroglial changesMicroglial markersReverse transcription-PCRAntigen presentationInterleukin-1betaBrain homogenatesMicrogliaPrP levelsBacterial lipopolysaccharideCellular activationPathological PrPActivated cellsBovine spongiformSpongiform encephalopathiesMolecular pathways