Chin Siang Ong, MBBS, PhD, MPH
Assistant Professor of Surgery (Surgical Outcomes)Cards
About
Research
Publications
2026
Genome and Transcriptome-Wide Analyses Identify Multiple Candidate Genes and a Significant Polygenic Contribution in Bicuspid Aortic Valve.
Thériault S, Holdcraft J, Sharipova D, Faucherre A, Debiec R, Peloso G, Al-Kassou B, Aranki S, Swan E, Ballotta A, Bellino M, Björck H, Boureau A, Braund P, Corriveau F, Dagenais F, Folkersen L, Forte A, Francke M, Frigiola A, Gorbatov S, Guo D, Habchi K, Heydarpour M, Isselbacher E, Jopling C, Laporte F, Le Scouarnec S, Li Z, Lichtner P, Maj C, Manikpurage H, Nelson C, Nguyen T, Norris R, Ong C, Pibarot P, Roychowdhury T, Sarubbi B, Simonet F, Sundt T, Surakka I, Tessler I, Willer C, Wittmann S, Yang B, Berezovets I, Doppler S, Dreßen M, Knoll K, Puehler T, Schunkert H, Avierinos J, Bissell M, Bolger A, Bossé Y, Bossone E, Brion M, Citro R, de Vincentiis C, Deeb G, Corte A, Dina C, Durst R, Ensminger S, Eriksson P, Evangelista A, Franco-Cereceda A, Gilon D, Giusti B, Hetherington S, Huggins G, Krane M, Le Tourneau T, Limongelli G, Mathieu P, Messika-Zeitoun D, Michelena H, Milewicz D, Muehlschlegel J, Murdock D, Nickenig G, Nistri S, Nöthen M, Pluchinotta F, Prakash S, Samani N, Schott J, Webb T, Zaffran S, Abdelilah-Seyfried S, Eagle K, Schumacher J, Trenkwalder T, Body S. Genome and Transcriptome-Wide Analyses Identify Multiple Candidate Genes and a Significant Polygenic Contribution in Bicuspid Aortic Valve. Circulation 2026 PMID: 41645906, PMCID: PMC13001617, DOI: 10.1161/circulationaha.125.074752.Peer-Reviewed Original ResearchCandidate genesPolygenic risk scoresGenetic architectureBicuspid aortic valveTranscriptome analysisGenome-wide association study meta-analysisMultiple common variantsMultiple candidate genesTranscriptome-wide analysisAortic valveTranscriptome-wideGenomic lociPrioritized genesUK BiobankCardiac developmentStudy meta-analysisCommon variantsPolygenic contributionRNA sequencingAdult aortic valveFrequent congenital heart defectsGene expressionGenesMolecular mechanismsAssociated with thoracic aortic aneurysm
2025
Instruction-Tuned Large Language Models for Clinical Data Extraction: Creating an Aortic Measurement Database from CT Radiology Reports
Erez E, Dankwa S, Tuttle M, Nasir A, Vallabhajosyula P, Schneider E, Assi R, Ong C. Instruction-Tuned Large Language Models for Clinical Data Extraction: Creating an Aortic Measurement Database from CT Radiology Reports. Journal Of Healthcare Informatics Research 2025, 9: 587-605. PMID: 41230242, PMCID: PMC12602774, DOI: 10.1007/s41666-025-00210-y.Peer-Reviewed Original ResearchLanguage modelFew-shotZero-ShotInformation extraction tasksMacro F1-scoreBERT-based modelsExtraction taskBERT modelChest Computed TomographyF1 scoreElectronic health recordsMinimal annotationStructure extractionTest setAortic measurementsAortic diameterHealth recordsThoracic aortic dilatationCT radiology reportsRelevant informationChest CT reportsHigh performanceAortic dilatationCT reportsAortic diseaseLung adenocarcinoma-derived IFN-γ promotes growth by modulating CD8+ T cell production of CCR5 chemokines
Kratzmeier C, Taheri M, Mei Z, Lim I, Khalil M, Carter-Cooper B, Fanaroff R, Ong C, Schneider E, Chang S, Leyder E, Li D, Luzina I, Banerjee A, Krupnick A. Lung adenocarcinoma-derived IFN-γ promotes growth by modulating CD8+ T cell production of CCR5 chemokines. Journal Of Clinical Investigation 2025, 135: e191070. PMID: 40553564, PMCID: PMC12404755, DOI: 10.1172/jci191070.Peer-Reviewed Original ResearchCD8+ T cellsIFN-gCCR5 chemokinesT cellsCD4+Foxp3+ T regulatory cellsCD8+ T-cell productionCancer cellsHuman lung cancer patientsLevels of IFN-gT regulatory cellsMurine lung adenocarcinomaLung adenocarcinoma modelLung cancer patientsMechanisms of immunoregulationCell line modelsLung cancer cellsTumor bedAdenocarcinoma modelTh1 cytokinesTumor microenvironmentImmunological environmentImmunoregulatory pathwaysCarcinogen-inducedTumor growthLung cancer
2024
SurgeryLLM: a retrieval-augmented generation large language model framework for surgical decision support and workflow enhancement
Ong C, Obey N, Zheng Y, Cohan A, Schneider E. SurgeryLLM: a retrieval-augmented generation large language model framework for surgical decision support and workflow enhancement. Npj Digital Medicine 2024, 7: 364. PMID: 39695316, PMCID: PMC11655968, DOI: 10.1038/s41746-024-01391-3.Peer-Reviewed Original Research
2023
Emergent Applications of Machine Learning for Diagnosing and Managing Appendicitis: A State-of-the-Art Review
Bhandarkar S, Tsutsumi A, Schneider E, Ong C, Paredes L, Brackett A, Ahuja V. Emergent Applications of Machine Learning for Diagnosing and Managing Appendicitis: A State-of-the-Art Review. Surgical Infections 2023, 25: 7-18. PMID: 38150507, DOI: 10.1089/sur.2023.201.Peer-Reviewed Original ResearchArtificial intelligence toolsNew artificial intelligence toolsArtificial neural networkSupport vector machineMachine learning-based toolLearning-based toolIntelligence toolsMachine learningUse casesNeural networkVector machineRandom forestAverage accuracyNovel solutionMachineEmergent applicationsAlgorithmOptimal modelQueriesHigh operator dependencyArt reviewAccuracyToolNetworkOperator dependencyImpact of intraoperative blood products, fluid administration, and persistent hypothermia on bleeding leading to reexploration after cardiac surgery
Shou B, Zhou A, Ong C, Alejo D, DiNatale J, Larson E, Lawton J, Schena S. Impact of intraoperative blood products, fluid administration, and persistent hypothermia on bleeding leading to reexploration after cardiac surgery. Journal Of Thoracic And Cardiovascular Surgery 2023, 168: 873-884.e4. PMID: 37839660, DOI: 10.1016/j.jtcvs.2023.10.011.Peer-Reviewed Original ResearchIntraoperative blood product transfusionIntensive care unit arrivalCore body temperatureBlood product transfusionCardiac surgeryPerioperative bleedingProduct transfusionCrystalloid administrationFluid administrationUnit arrivalRisk factorsAdult cardiac surgery patientsGreater postoperative morbidityIntraoperative blood productsSevere postoperative bleedingCardiac surgery patientsBlood product administrationIntravenous fluid administrationLower core body temperatureSuch risk factorsElectronic medical recordsPersistent hypothermiaPostoperative bleedingPostoperative morbidityIntraoperative fluidEffect of concurrent mitral valve surgery for secondary mitral regurgitation upon mortality after aortic valve replacement or coronary artery bypass surgery
Asher S, Ong C, Malapero R, Heydarpour M, Malzberg G, Shahram J, Nguyen T, Shook D, Shernan S, Shekar P, Kaneko T, Citro R, Muehlschlegel J, Body S. Effect of concurrent mitral valve surgery for secondary mitral regurgitation upon mortality after aortic valve replacement or coronary artery bypass surgery. Frontiers In Cardiovascular Medicine 2023, 10: 1202174. PMID: 37840960, PMCID: PMC10570832, DOI: 10.3389/fcvm.2023.1202174.Peer-Reviewed Original ResearchAortic valve replacement surgeryCoronary artery bypass graftMitral valve repairSecondary mitral regurgitationModerate mitral regurgitationAortic valve replacementCoronary artery bypassArtery bypass graftValve replacement surgeryMitral regurgitationValve repairArtery bypassValve replacementBypass graftReplacement surgeryCoronary artery bypass graft populationSevere secondary mitral regurgitationCoronary Artery Bypass GraftingCoronary artery bypass surgeryArtery Bypass GraftingArtery bypass surgeryLong-term mortalityMitral valve surgeryMitral valve operationsLong-term survivalHistorical Accounts of Congenital Heart Surgery
Mavroudis C, Ong C, Vricella L, Cameron D. Historical Accounts of Congenital Heart Surgery. World Journal For Pediatric And Congenital Heart Surgery 2023, 14: 626-641. PMID: 37737603, DOI: 10.1177/21501351231186415.Peer-Reviewed Original ResearchRecruited macrophages elicit atrial fibrillation
Hulsmans M, Schloss M, Lee I, Bapat A, Iwamoto Y, Vinegoni C, Paccalet A, Yamazoe M, Grune J, Pabel S, Momin N, Seung H, Kumowski N, Pulous F, Keller D, Bening C, Green U, Lennerz J, Mitchell R, Lewis A, Casadei B, Iborra-Egea O, Bayes-Genis A, Sossalla S, Ong C, Pierson R, Aster J, Rohde D, Wojtkiewicz G, Weissleder R, Swirski F, Tellides G, Tolis G, Melnitchouk S, Milan D, Ellinor P, Naxerova K, Nahrendorf M. Recruited macrophages elicit atrial fibrillation. Science 2023, 381: 231-239. PMID: 37440641, PMCID: PMC10448807, DOI: 10.1126/science.abq3061.Peer-Reviewed Original ResearchConceptsAtrial fibrillationStromal cellsMitral valve regurgitationHeart failureValve regurgitationInflammatory monocytesMacrophage expansionMonocyte migrationMouse atriaFibrillationHuman atriumAtriumCell-cell interaction analysisSingle-cell transcriptomesMiceCell compositionHypertensionTranscriptome changesImmunotherapySPP1CellsRegurgitationObesityPatientsArrhythmias779 Utilization of Palliative Care in Patients Succumbing to Primary Burn Injury
Savetamal A, Canner J, Gibbs K, Graetz E, Ong C, Schneider E. 779 Utilization of Palliative Care in Patients Succumbing to Primary Burn Injury. Journal Of Burn Care & Research 2023, 44: s177-s177. PMCID: PMC10464588, DOI: 10.1093/jbcr/irad045.254.Peer-Reviewed Original ResearchPalliative careBaux scoreBurn injuryPC consultationBlack patientsBurn patientsHigher Baux scoresPalliative care usePalliative care consultationMultivariable Poisson regressionNational Inpatient SampleUrban teaching hospitalGreater likelihoodNumber of diagnosesPercentage of bodyNon-teaching hospitalsChi-square testNation-wide studyPC encountersInhalation injuryClinical characteristicsHospital dischargeInpatient deathOlder patientsYounger patients