2023
Sleep dysfunction mediates the relationship between hypothalamic-insula connectivity and anxiety-depression symptom severity bidirectionally in young adults
Li G, Chen Y, Chaudhary S, Li C, Hao D, Yang L, Li C. Sleep dysfunction mediates the relationship between hypothalamic-insula connectivity and anxiety-depression symptom severity bidirectionally in young adults. NeuroImage 2023, 279: 120340. PMID: 37611815, DOI: 10.1016/j.neuroimage.2023.120340.Peer-Reviewed Original ResearchConceptsPittsburgh Sleep Quality IndexRight insulaSymptom severityMediation analysisSleep dysfunctionWhole-brain regressionHuman Connectome Project datasetSubjective mood stateYoung adultsState functional connectivityDepression symptom severityNegative emotionsCognitive performanceEmotional deficitsEmotional statesPotential sex differencesAffective functionsDrinking severityMood statesMotivated behaviorFunctional connectivityPoor sleep qualityRSFCSleep Quality IndexSleep quality
2020
Effects of early ketamine exposure on cerebral gray matter volume and functional connectivity
Hung CC, Liu YH, Huang CC, Chou CY, Chen CM, Duann JR, Li CR, Lee TS, Lin CP. Effects of early ketamine exposure on cerebral gray matter volume and functional connectivity. Scientific Reports 2020, 10: 15488. PMID: 32968108, PMCID: PMC7512006, DOI: 10.1038/s41598-020-72320-z.Peer-Reviewed Original ResearchConceptsGray matter volumeCerebral gray matter volumeKetamine exposureFunctional connectivityMatter volumeKetamine usersBrain structuresLower gray matter volumeFunctional brain changesTreatment of depressionAdolescent-onset groupCerebral functional organizationHigher functional connectivitySuperior frontal gyrusInferior parietal lobuleMedial orbitofrontal cortexSeed-based correlation analysisKetamine groupBrain changesKetamine abuseLarge cohortRight insulaLeft precuneusKetamine misuseRight precuneusAltered multimodal magnetic resonance parameters of basal nucleus of Meynert in Alzheimer’s disease
Zheng W, Li H, Cui B, Liang P, Wu Y, Han X, Li C, Li K, Wang Z. Altered multimodal magnetic resonance parameters of basal nucleus of Meynert in Alzheimer’s disease. Annals Of Clinical And Translational Neurology 2020, 7: 1919-1929. PMID: 32888399, PMCID: PMC7545587, DOI: 10.1002/acn3.51176.Peer-Reviewed Original ResearchConceptsGray matter volumeHealthy controlsFunctional connectivityBasal nucleusResting-state functional connectivityDaily living statusLower gray matter volumeArterial spin labeling imagingWhole-brain functional connectivityRegional blood flowPostmortem human brainVoxel-based morphometryCholinergic dysfunctionHigher rCBFRight insula