2019
ZFYVE21 is a complement-induced Rab5 effector that activates non-canonical NF-κB via phosphoinosotide remodeling of endosomes
Fang C, Manes TD, Liu L, Liu K, Qin L, Li G, Tobiasova Z, Kirkiles-Smith NC, Patel M, Merola J, Fu W, Liu R, Xie C, Tietjen GT, Nigrovic PA, Tellides G, Pober JS, Jane-wit D. ZFYVE21 is a complement-induced Rab5 effector that activates non-canonical NF-κB via phosphoinosotide remodeling of endosomes. Nature Communications 2019, 10: 2247. PMID: 31113953, PMCID: PMC6529429, DOI: 10.1038/s41467-019-10041-2.Peer-Reviewed Original ResearchMeSH KeywordsAllograftsAnimalsCarrier ProteinsCell LineComplement Membrane Attack ComplexCoronary VesselsDisease Models, AnimalEndosomesFemaleGraft RejectionHuman Umbilical Vein Endothelial CellsHumansIntracellular Signaling Peptides and ProteinsMembrane ProteinsMiceMice, SCIDNF-kappa BPhosphatidylinositol PhosphatesRab5 GTP-Binding ProteinsUbiquitin-Protein LigasesVasculitisConceptsNF-κB-inducing kinaseMembrane attack complexNon-canonical NF-κBNF-κBEC activationEndothelial cellsTransplant organ rejectionConnective tissue diseaseHumanized mouse modelAllograft vasculopathySynovial tissueTissue diseaseVascular inflammationOrgan rejectionPharmacologic alterationsMouse modelDependent mannerAttack complexProteasome-dependent degradationInduction
2016
Regulation of aldosterone secretion by Cav1.3
Xie CB, Haris Shaikh L, Garg S, Tanriver G, Teo AE, Zhou J, Maniero C, Zhao W, Kang S, Silverman RB, Azizan EA, Brown MJ. Regulation of aldosterone secretion by Cav1.3. Scientific Reports 2016, 6: 24697. PMID: 27098837, PMCID: PMC4876952, DOI: 10.1038/srep24697.Peer-Reviewed Original ResearchConceptsAldosterone-producing adenomaH295R cellsL-type calcium channel Cav1.3Role of Cav1.3Human adrenocortical cell lineVascular side effectsHuman adrenal cellsAdrenocortical cell lineAldosterone secretionAntihypertensive drug nifedipinePrimary hyperaldosteronismAldosterone productionZona glomerulosaInvestigational drugsSide effectsChannel Cav1.3Cav1.3Adrenal cellsCav1.3 channelsNovel antagonistCell linesNifedipineDrug nifedipineCompound 8Cells