2020
Cytomorphologic features of thyroid disease in patients with DICER1 mutations: A report of cytology–histopathology correlation in 7 patients
Darbinyan A, Morotti R, Cai G, Prasad ML, Christison‐Lagay E, Dinauer C, Adeniran AJ. Cytomorphologic features of thyroid disease in patients with DICER1 mutations: A report of cytology–histopathology correlation in 7 patients. Cancer Cytopathology 2020, 128: 746-756. PMID: 32897650, DOI: 10.1002/cncy.22329.Peer-Reviewed Original ResearchConceptsDICER1 mutationsThyroid diseaseThyroid carcinomaScreening of patientsFine-needle aspiration samplesMonitoring of patientsDiagnostic cytologic featuresPapillary thyroid carcinomaGermline DICER1 mutationsThyroid fine-needle aspiration samplesFNA evaluationUndetermined significanceDifferent somatic variantsThyroid cancerScant colloidNeoplastic lesionsHistopathological analysisCytomorphologic featuresDICER1 syndromeModerate cellularityCytologic featuresFollicular carcinomaFollicular lesionsInconspicuous nucleoliFollicular neoplasm
2015
Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer
Francis GL, Waguespack SG, Bauer AJ, Angelos P, Benvenga S, Cerutti JM, Dinauer CA, Hamilton J, Hay ID, Luster M, Parisi MT, Rachmiel M, Thompson GB, Yamashita S. Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid 2015, 25: 716-759. PMID: 25900731, PMCID: PMC4854274, DOI: 10.1089/thy.2014.0460.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsDifferentiated thyroid cancerAmerican Thyroid AssociationThyroid cancerThyroid nodulesUnited States Preventive Services Task ForceFine needle aspiration cytologyRadioactive iodine therapyLong-term outcomesManagement of childrenFollicular thyroid cancerTask ForceScientific evidenceYears of ageLong-term harmIodine therapyPostoperative stagingAggressive treatmentThyrotropin suppressionClinical presentationPreoperative stagingSurgical managementOptimal careThyroid AssociationAspiration cytologyHigh risk
2002
Nitrotyrosine, inducible nitric oxide synthase (iNOS), and endothelial nitric oxide synthase (eNOS) are increased in thyroid tumors from children and adolescents
Patel A, Fenton C, Terrell R, Powers P, Dinauer C, Tuttle R, Francis G. Nitrotyrosine, inducible nitric oxide synthase (iNOS), and endothelial nitric oxide synthase (eNOS) are increased in thyroid tumors from children and adolescents. Journal Of Endocrinological Investigation 2002, 25: 675-683. PMID: 12240898, DOI: 10.1007/bf03345100.Peer-Reviewed Original ResearchConceptsInducible nitric oxide synthaseEndothelial nitric oxide synthaseFollicular thyroid carcinomaPapillary thyroid carcinomaNitric oxide synthaseAutoimmune lesionsBenign adenomasMultinodular goiterNitric oxideThyroid tumorsNormal thyroidOxide synthaseThyroid carcinomaAutoimmune thyroid diseaseNeuronal NO synthaseVascular endothelial growth factorHigh-power fieldMatrix metalloproteinase (MMP) expression by differentiated thyroid carcinoma of children and adolescents
Patel A, Straight A, Mann H, Duffy E, Fenton C, Dinauer C, Tuttle R, Francis G. Matrix metalloproteinase (MMP) expression by differentiated thyroid carcinoma of children and adolescents. Journal Of Endocrinological Investigation 2002, 25: 403-408. PMID: 12035934, DOI: 10.1007/bf03344028.Peer-Reviewed Original ResearchConceptsPapillary thyroid carcinomaFollicular thyroid carcinomaThyroid carcinomaTIMP-1MMP-1MMP-1 expressionMatrix metalloproteinasesMT1-MMPRecurrent papillary thyroid carcinomaTumor-associated inflammatory cellsPrevious pathological studiesTumor-associated lymphocytesDifferentiated thyroid carcinomaTIMP-1 expressionMatrix metalloproteinase expressionThyroid cancer cellsIntensity of stainingBenign thyroid lesionsMembrane type-1 matrix metalloproteinasesInflammatory cellsPathological studiesNormal thyroid cellsMalignant lesionsBenign lesionsMetalloproteinase expressionThyroid carcinomas that express telomerase follow a more aggressive clinical course in children and adolescents
Straight A, Patel A, Fenton C, Dinauer C, Tuttle R, Francis G. Thyroid carcinomas that express telomerase follow a more aggressive clinical course in children and adolescents. Journal Of Endocrinological Investigation 2002, 25: 302-308. PMID: 12030599, DOI: 10.1007/bf03344009.Peer-Reviewed Original ResearchConceptsFollicular thyroid carcinomaPapillary thyroid carcinomaThyroid carcinomaMalignant tumorsTelomerase expressionDisease-free survivalAggressive clinical courseChildhood thyroid cancerHigh recurrence riskYr of ageBenign thyroid lesionsLow telomerase expressionAutoimmune lesionsClinical courseDistant metastasisDirect invasionThyroid cancerBenign tumorsBlind examinerOriginal tumorBenign lesionsRecurrence riskTumorsThyroid lesionsCarcinoma
2001
Infiltration of Differentiated Thyroid Carcinoma by Proliferating Lymphocytes Is Associated with Improved Disease-Free Survival for Children and Young Adults1
Gupta S, Patel A, Folstad A, Fenton C, Dinauer C, Tuttle R, Conran R, Francis G. Infiltration of Differentiated Thyroid Carcinoma by Proliferating Lymphocytes Is Associated with Improved Disease-Free Survival for Children and Young Adults1. The Journal Of Clinical Endocrinology & Metabolism 2001, 86: 1346-1354. PMID: 11238531, DOI: 10.1210/jcem.86.3.7310.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinoma, FollicularAdolescentAdultCarcinoma, MedullaryCarcinoma, PapillaryCell DivisionChildDisease-Free SurvivalFemaleHumansImmunohistochemistryKi-67 AntigenLeukocyte Common AntigensLymphatic MetastasisLymphocytesMaleNeoplasm MetastasisNeoplasm Recurrence, LocalThyroid NeoplasmsConceptsDisease-free survivalPapillary thyroid carcinomaImproved disease-free survivalTumor-associated lymphocytesNumber of lymphocytesThyroid cancerThyroid carcinomaFollicular thyroid carcinomaHigh-power fieldYoung adultsAutoimmune thyroiditisImmune responseKi-67 positive lymphocytesRegional lymph node involvementMultifocal papillary thyroid carcinomaChildhood papillary thyroid carcinomasLymph node involvementDifferentiated thyroid cancerDifferentiated thyroid carcinomaLong-term outcomesPower fieldPresence of lymphocytesMedullary thyroid carcinomaHigh proliferation indexMajority of PTC
2000
The Expression of Vascular Endothelial Growth Factor and the Type 1 Vascular Endothelial Growth Factor Receptor Correlate with the Size of Papillary Thyroid Carcinoma in Children and Young Adults
Fenton C, Patel A, Dinauer C, Robie D, Tuttle R, Francis G. The Expression of Vascular Endothelial Growth Factor and the Type 1 Vascular Endothelial Growth Factor Receptor Correlate with the Size of Papillary Thyroid Carcinoma in Children and Young Adults. Thyroid 2000, 10: 349-357. PMID: 10807064, DOI: 10.1089/thy.2000.10.349.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinoma, FollicularAdolescentAdultCarcinoma, PapillaryCase-Control StudiesChildEndothelial Growth FactorsFemaleHumansLymphokinesMaleProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesReceptors, Growth FactorThyroid NeoplasmsVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-1Vascular Endothelial Growth FactorsConceptsVascular endothelial growth factorExpression of VEGFPapillary thyroid carcinomaEndothelial growth factorThyroid carcinomaBenign lesionsYoung adultsClinical outcomesThyroid cancerPTC sizeVEGF expressionFlt-1Growth factorRetrospective clinical outcomesChildhood thyroid cancerThyroid tissue blocksFollicular thyroid carcinomaFlt-1 expressionRecurrent diseaseSolid tumorsCarcinomaVEGF receptorsReceptor correlatesLesionsTissue blocks
1998
Clinical features associated with metastasis and recurrence of differentiated thyroid cancer in children, adolescents and young adults
Dinauer C, Tuttle M, Robie D, McClellan D, Svec R, Adair C, Francis G. Clinical features associated with metastasis and recurrence of differentiated thyroid cancer in children, adolescents and young adults. Clinical Endocrinology 1998, 49: 619-628. PMID: 10197078, DOI: 10.1046/j.1365-2265.1998.00584.x.Peer-Reviewed Original ResearchConceptsDifferentiated thyroid cancerThyroid cancerClinical featuresMultifocal tumorsCases of FTCPalpable cervical lymphadenopathyRisk of recurrenceYears of ageCases of PTCCervical lymphadenopathyDistant recurrenceYounger patientsTumor RegistryFTC groupPathological findingsRetrospective studyLarge tumorsUnivariate analysisFollicular variantPTC groupHigh riskPatientsRecurrenceLower mortalityGreater risk