2003
Inducible, brain region-specific expression of a dominant negative mutant of c-Jun in transgenic mice decreases sensitivity to cocaine
Peakman M, Colby C, Perrotti L, Tekumalla P, Carle T, Ulery P, Chao J, Duman C, Steffen C, Monteggia L, Allen M, Stock J, Duman R, McNeish J, Barrot M, Self D, Nestler E, Schaeffer E. Inducible, brain region-specific expression of a dominant negative mutant of c-Jun in transgenic mice decreases sensitivity to cocaine. Brain Research 2003, 970: 73-86. PMID: 12706249, DOI: 10.1016/s0006-8993(03)02230-3.Peer-Reviewed Original ResearchConceptsNucleus accumbensFos proteinAdult miceRewarding effectsTransgenic miceBrain regionsBrain region-specific expressionCocaine-induced locomotor activityTranscription factor nuclear factor-kappaBRegion-specific expressionAdministration of cocaineChronic drug administrationGlutamate receptor subunit GluR2Chronic cocaine administrationNuclear factor-kappaBProtein kinase Cdk5C-JunAP-1-mediated transcriptionCocaine administrationFos responsePlace preferenceSubunit GluR2Drug AdministrationFactor-kappaBLocomotor activity
1996
A role for GABAergic inhibition in electrosensory processing and common mode rejection in the dorsal nucleus of the little skate, Raja erinacea
Duman C, Bodznick D. A role for GABAergic inhibition in electrosensory processing and common mode rejection in the dorsal nucleus of the little skate, Raja erinacea. Journal Of Comparative Physiology A 1996, 179: 797-807. PMID: 8956498, DOI: 10.1007/bf00207358.Peer-Reviewed Original ResearchConceptsGABAergic inhibitionCommon-mode rejection mechanismAnimal's own ventilationReceptor antagonist SR95531Second-order neuronsPrimary afferentsAfferent inputCommissural pathwayContralateral sideDorsal nucleusCommissural cellsSpontaneous activityElectrosensory primary afferentsContralateral inhibitionSR95531Suppress responsesLocal applicationGABAInhibitionElectrosensory stimuliRaja erinaceaElectrosensory processingStimuliResponseAfferents