2024
Ketamine induces multiple individually distinct whole-brain functional connectivity signatures
Moujaes F, Ji J, Rahmati M, Burt J, Schleifer C, Adkinson B, Savic A, Santamauro N, Tamayo Z, Diehl C, Kolobaric A, Flynn M, Rieser N, Fonteneau C, Camarro T, Xu J, Cho Y, Repovs G, Fineberg S, Morgan P, Seifritz E, Vollenweider F, Krystal J, Murray J, Preller K, Anticevic A. Ketamine induces multiple individually distinct whole-brain functional connectivity signatures. ELife 2024, 13: e84173. PMID: 38629811, PMCID: PMC11023699, DOI: 10.7554/elife.84173.Peer-Reviewed Original ResearchConceptsResponse to ketamineAcute ketamineBehavioral effectsQuantified resting-state functional connectivityEffects of acute ketamineSymptom variationResting-state functional connectivityTreatment-resistant depressionFunctional connectivity signaturesGlobal brain connectivitySingle-subject levelInter-individual variabilityPlacebo-controlled studyFunctional connectivityConnectivity signaturesBrain connectivityHealthy participantsSingle-blind placebo-controlled studyNeural variationsTreatment conditionsKetamineGene expression targetsPharmacological biomarkersPilot awardParvalbumin
2023
Cross Atlas Remapping via Optimal Transport (CAROT): Creating connectomes for different atlases when raw data is not available
Dadashkarimi J, Karbasi A, Liang Q, Rosenblatt M, Noble S, Foster M, Rodriguez R, Adkinson B, Ye J, Sun H, Camp C, Farruggia M, Tejavibulya L, Dai W, Jiang R, Pollatou A, Scheinost D. Cross Atlas Remapping via Optimal Transport (CAROT): Creating connectomes for different atlases when raw data is not available. Medical Image Analysis 2023, 88: 102864. PMID: 37352650, PMCID: PMC10526726, DOI: 10.1016/j.media.2023.102864.Peer-Reviewed Original ResearchConceptsDifferent atlasesRaw data accessWeb applicationData accessOpen source dataSource codePatient privacyOptimal transportRaw dataStorage concernsLarge-scale data collection effortsOriginal counterpartsExtensive setData collection effortsProcessing effortPredictive modelNeuroimaging dataDownstream analysisPrivacyAtlasesCollection effortsComputationalTime seriesDatasetConnectome
2021
Mapping brain-behavior space relationships along the psychosis spectrum
Ji JL, Helmer M, Fonteneau C, Burt JB, Tamayo Z, Demšar J, Adkinson BD, Savić A, Preller KH, Moujaes F, Vollenweider FX, Martin WJ, Repovš G, Cho YT, Pittenger C, Murray JD, Anticevic A. Mapping brain-behavior space relationships along the psychosis spectrum. ELife 2021, 10: e66968. PMID: 34313219, PMCID: PMC8315806, DOI: 10.7554/elife.66968.Peer-Reviewed Original ResearchConceptsPsychosis spectrum disordersEffective patient-specific therapiesPSD patientsAllen Human Brain AtlasReceptor manipulationPatient-specific therapiesPsychiatric disordersBiomarker endpointsCognitive deficitsIndividualized predictionHuman Brain AtlasMolecular targetsActionable pathSymptom variationPsychosis spectrumPsychopathology symptomsBrain mapsCurrent sample sizeDisordersBrain atlas
2020
Psilocybin Induces Time-Dependent Changes in Global Functional Connectivity
Preller KH, Duerler P, Burt JB, Ji JL, Adkinson B, Stämpfli P, Seifritz E, Repovš G, Krystal JH, Murray JD, Anticevic A, Vollenweider FX. Psilocybin Induces Time-Dependent Changes in Global Functional Connectivity. Biological Psychiatry 2020, 88: 197-207. PMID: 32111343, DOI: 10.1016/j.biopsych.2019.12.027.Peer-Reviewed Original ResearchConceptsFunctional connectivityBaseline connectivityResting-state functional connectivityGlobal functional connectivityBrain-wide connectivityHealthy human participantsPersonalized medicine approachPeak effectUse of psilocybinMechanism of actionSerotonin 2ATime-dependent mannerCrossover studyPredictive markerPsychedelic treatmentMedicine approachReceptor systemSensory regionsClinical contextTime pointsAssociative regionsDifferent test daysAdministrationTest dayTime-dependent changes
2017
Searching for Cross-Diagnostic Convergence: Neural Mechanisms Governing Excitation and Inhibition Balance in Schizophrenia and Autism Spectrum Disorders
Foss-Feig JH, Adkinson BD, Ji JL, Yang G, Srihari VH, McPartland JC, Krystal JH, Murray JD, Anticevic A. Searching for Cross-Diagnostic Convergence: Neural Mechanisms Governing Excitation and Inhibition Balance in Schizophrenia and Autism Spectrum Disorders. Biological Psychiatry 2017, 81: 848-861. PMID: 28434615, PMCID: PMC5436134, DOI: 10.1016/j.biopsych.2017.03.005.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSpectrum disorderFunctional magnetic resonance imagingRecent theoretical accountsEarly course schizophreniaNeurodevelopmental disordersPharmacological challenge studiesNeural correlatesNeuroscience literatureTheoretical accountsNeural circuitryTheoretical neuroscienceNoninvasive neuroimagingBehavioral dysfunctionFuture researchNeuropsychiatric conditionsComputational modelSchizophreniaProton magnetic resonance spectroscopyDisordersInhibition imbalanceMagnetic resonance imagingDistinct modalitiesPoint of convergenceInhibition balance