2003
Control of spatially heterogeneous and time-varying cellular reaction networks: a new summation law
Peletier M, Westerhoff H, Kholodenko B. Control of spatially heterogeneous and time-varying cellular reaction networks: a new summation law. Journal Of Theoretical Biology 2003, 225: 477-487. PMID: 14615206, DOI: 10.1016/s0022-5193(03)00289-3.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell MembraneComputational BiologyDiffusionModels, BiologicalPhosphoric Monoester HydrolasesPhosphotransferasesProteinsSignal TransductionTime FactorsConceptsMetabolic control analysisMembrane transportKinase/phosphatase systemCellular reaction networksIntracellular signaling pathwaysProtein networkIntracellular transportPhosphatase systemSignaling pathwaysControl coefficientsCell sizeSpherical cellsClassical metabolic control analysisActive mechanismProtein
1999
Spatial gradients of cellular phospho‐proteins
Brown G, Kholodenko B. Spatial gradients of cellular phospho‐proteins. FEBS Letters 1999, 457: 452-454. PMID: 10471827, DOI: 10.1016/s0014-5793(99)01058-3.Peer-Reviewed Original ResearchConceptsCellular signalingProtein kinaseDifferent cellular geometriesCellular locationPlasma membranePhosphorylated formPlanar membranesProtein diffusionPhosphatase activityKinaseCellular geometryProtein diffusion coefficientsSpatial gradientsSpherical cellsProteinMembraneSuch gradientsCellsSignalingCytoplasmPhosphataseImportant implicationsGradientPotential size