Featured Publications
Methods for mediation analysis with high-dimensional DNA methylation data: Possible choices and comparisons
Clark-Boucher D, Zhou X, Du J, Liu Y, Needham B, Smith J, Mukherjee B. Methods for mediation analysis with high-dimensional DNA methylation data: Possible choices and comparisons. PLOS Genetics 2023, 19: e1011022. PMID: 37934796, PMCID: PMC10655967, DOI: 10.1371/journal.pgen.1011022.Peer-Reviewed Original ResearchConceptsBayesian Sparse Linear Mixed ModelMediation analysisHigh-dimensional mediation analysisMulti-ethnic cohortEpigenetic researchHealth outcomesHigh-dimensional DNA methylation dataLinear mixed modelsDNA methylation dataContinuous outcomesEvaluate DNA methylationDNA methylationMethylation dataDNAm dataMixed modelsDiverse simulationsSeamless implementationModern statistical methodsMediation effectR packageUnited StatesOutcomes
2024
Cross-shift changes in pulmonary function and occupational exposure to particulate matter among e-waste workers in Ghana
Laskaris Z, O'Neill M, Batterman S, Mukherjee B, Fobil J, Robins T. Cross-shift changes in pulmonary function and occupational exposure to particulate matter among e-waste workers in Ghana. Frontiers In Public Health 2024, 12: 1368112. PMID: 38784567, PMCID: PMC11111984, DOI: 10.3389/fpubh.2024.1368112.Peer-Reviewed Original ResearchConceptsE-waste workersExposure to particulate matterE-wasteParticulate matterAgbogbloshie e-waste siteInhalation exposure to particulate matterE-waste sitesBurning e-wasteConcentrations of PMHealth-based guidelinesExposure to airborne pollutantsExposure to PMOccupational exposure to particulate matterCross-shift changesElectronic-wasteForced vital capacityPersonal PMPM exposureAirborne pollutantsLinear mixed modelsBreathing zone concentrationsPulmonary functionComparison populationRecovery workersMixed modelsCross-Sectional Associations between Prenatal Per- and Poly-Fluoroalkyl Substances and Bioactive Lipids in Three Environmental Influences on Child Health Outcomes (ECHO) Cohorts
Suthar H, Manea T, Pak D, Woodbury M, Eick S, Cathey A, Watkins D, Strakovsky R, Ryva B, Pennathur S, Zeng L, Weller D, Park J, Smith S, DeMicco E, Padula A, Fry R, Mukherjee B, Aguiar A, Geiger S, Ng S, Huerta-Montanez G, Vélez-Vega C, Rosario Z, Cordero J, Zimmerman E, Woodruff T, Morello-Frosch R, Schantz S, Meeker J, Alshawabkeh A, Aung M, Outcomes O. Cross-Sectional Associations between Prenatal Per- and Poly-Fluoroalkyl Substances and Bioactive Lipids in Three Environmental Influences on Child Health Outcomes (ECHO) Cohorts. Environmental Science And Technology 2024, 58: 8264-8277. PMID: 38691655, PMCID: PMC11097396, DOI: 10.1021/acs.est.4c00094.Peer-Reviewed Original ResearchConceptsPFAS mixtureLinear mixed modelsBioactive lipidsChild health outcomesCross-sectional associationsPrenatal PFAS exposureBioactive lipid levelsPoly-fluoroalkyl substancesQuantile g-computationMixed modelsGestational outcomesHealth outcomesPregnancy outcomesPregnant womenCombined cohortG-computationCohort analysisProgram cohortQuartile increaseLipid levelsCohortPositive associationMeta-analysisEnvironmental influencesPFAS exposure
2023
Mortality and Severe Complications Among Newly Graduated Surgeons in the United States
Howard R, Thelen A, Chen X, Gates R, Krumm A, Millis M, Gupta T, Brown C, Bandeh-Ahmadi H, Wnuk G, Yee C, Ryan A, Mukherjee B, Dimick J, George B. Mortality and Severe Complications Among Newly Graduated Surgeons in the United States. Annals Of Surgery 2023, 279: 555-560. PMID: 37830271, PMCID: PMC10939969, DOI: 10.1097/sla.0000000000006128.Peer-Reviewed Original ResearchConceptsYears of practiceSevere complicationsRelative riskGeneral surgeonsIndependent practiceYears of independent practiceCareer surgeonsRelative risk of mortalityAmerican Board of SurgerySurgeon yearsMixed modelsSurgeon characteristicsRate of mortalityMedicare claimsComplicationsSurgeonsPatient outcomesPatientsMortalityAmerican BoardOutcomesEvaluating Educational Outcomes Using Patient Outcomes of New Surgeons Performing Partial Colectomy Compared to Cholecystectomy
George B, Thelen A, Howard R, Kendrick D, Chen X, Clark M, Gupta T, Brown C, Bandeh-Ahmadi H, Luckoski J, Wnuk G, Fan Z, Krumm A, Ryan A, Buyske J, Mukherjee B, Dimick J. Evaluating Educational Outcomes Using Patient Outcomes of New Surgeons Performing Partial Colectomy Compared to Cholecystectomy. Academic Medicine 2023, 98: s143-s148. PMID: 37983406, DOI: 10.1097/acm.0000000000005368.Peer-Reviewed Original ResearchConceptsPartial colectomyPatient outcomesYears of practiceExperienced surgeonSurgeon yearsRisk-adjusted ratesCholecystectomyColectomyTraining of surgeonsInpatient cholecystectomyComplicationsImprove surgical educationPatientsEvaluate educational outcomesSurgeonsSurgical residentsBenefit patientsInpatient operationsResidency trainingStudy periodDeathOutcomesSurgical educationMixed modelsTraining
2021
Efficient mixed model approach for large-scale genome-wide association studies of ordinal categorical phenotypes
Bi W, Zhou W, Dey R, Mukherjee B, Sampson J, Lee S. Efficient mixed model approach for large-scale genome-wide association studies of ordinal categorical phenotypes. American Journal Of Human Genetics 2021, 108: 825-839. PMID: 33836139, PMCID: PMC8206161, DOI: 10.1016/j.ajhg.2021.03.019.Peer-Reviewed Original ResearchConceptsOrdinal categorical phenotypesGenome-wide association studiesCategorical phenotypesGenome-wide significant variantsRare variantsPhenotype distributionControlled type I error ratesType I error rateMixed model approachArray genotypingAssociation studiesCommon variantsQuantitative traitsSignificant variantsLogistic mixed modelsLack of analysis toolsUK BiobankLinear mixed model approachPhenotypeAssociation TestVariantsMixed modelsSignificance levelMAFTraits
2019
Longitudinal trends in perfluoroalkyl and polyfluoroalkyl substances among multiethnic midlife women from 1999 to 2011: The Study of Women′s Health Across the Nation
Ding N, Harlow S, Batterman S, Mukherjee B, Park S. Longitudinal trends in perfluoroalkyl and polyfluoroalkyl substances among multiethnic midlife women from 1999 to 2011: The Study of Women′s Health Across the Nation. Environment International 2019, 135: 105381. PMID: 31841808, PMCID: PMC7374929, DOI: 10.1016/j.envint.2019.105381.Peer-Reviewed Original ResearchConceptsMidlife womenWomen's HealthBlack womenStudy of Women's HealthChinese womenLongitudinal trendsTemporal trendsBody mass indexSerum concentrationsLinear mixed modelsParous womenFollow-up visitPFAS homologuesPFNA concentrationsRace/ethnicityMass indexSerum PFAS concentrationsMidlifePatterns of exposurePolyfluoroalkyl substances concentrationsLongitudinal declineWomenAssociated with lower concentrationsHealthMixed models
2018
Foetal ultrasound measurement imputations based on growth curves versus multiple imputation chained equation (MICE)
Ferguson K, Yu Y, Cantonwine D, McElrath T, Meeker J, Mukherjee B. Foetal ultrasound measurement imputations based on growth curves versus multiple imputation chained equation (MICE). Paediatric And Perinatal Epidemiology 2018, 32: 469-473. PMID: 30016545, PMCID: PMC6939297, DOI: 10.1111/ppe.12486.Peer-Reviewed Original ResearchConceptsLinear mixed modelsComplete-case analysisMultiple imputationEpidemiological studies of risk factorsImputed datasetsComplete-caseDemographic factorsStudy of risk factorsLIFECODES birth cohortUltrasound measurementsCalculate associationsBirth cohortCross-sectionEpidemiological studiesRisk factorsStudy visitsLongitudinal analysisParametric linear mixed modelImputationMissing dataMixed modelsLongitudinal measurementsSample sizeCovariate dataGrowth restrictionEvaluating the Risk of Noise-Induced Hearing Loss Using Different Noise Measurement Criteria
Roberts B, Seixas N, Mukherjee B, Neitzel R. Evaluating the Risk of Noise-Induced Hearing Loss Using Different Noise Measurement Criteria. Annals Of Work Exposures And Health 2018, 62: 295-306. PMID: 29415217, DOI: 10.1093/annweh/wxy001.Peer-Reviewed Original ResearchConceptsHearing threshold levelsHearing outcomesHearing lossOccupational Safety and Health AdministrationRisk of noise-induced hearing lossHealth AdministrationNoise exposureOccupational Safety and HealthNoise-induced hearing lossInstitute of Occupational Safety and HealthSafety and HealthNational Institute of Occupational Safety and HealthCohort of construction workersMixed modelsDuration of participationAssessment of noise exposureMeasures of exposureHearing levelAkaike’s information criterion differencesConstruction workersAverage noise levelLinear mixed modelsLAVGContinuous averagingOSHA
2016
Utilizing Longitudinal Measures of Fetal Growth to Create a Standard Method to Assess the Impacts of Maternal Disease and Environmental Exposure
Cantonwine D, Ferguson K, Mukherjee B, Chen Y, Smith N, Robinson J, Doubilet P, Meeker J, McElrath T. Utilizing Longitudinal Measures of Fetal Growth to Create a Standard Method to Assess the Impacts of Maternal Disease and Environmental Exposure. PLOS ONE 2016, 11: e0146532. PMID: 26731406, PMCID: PMC4701464, DOI: 10.1371/journal.pone.0146532.Peer-Reviewed Original ResearchConceptsFetal growthCohort study populationContemporary obstetric practiceZ-scoreNon-anomalous pregnanciesFetal sizeAssociated with increased fetal sizeClinical dataIncreased risk of perinatal morbidityMixed modelsRisk of perinatal morbidityStandard populationAssociated with fetal growthMeasures of fetal growthPrenatal careAssociated with factorsLinear mixed modelsMaternal BMIObstetric practiceEpidemiological researchMaternal smokingTrimester ultrasound evaluationSuboptimal fetal growthUS populationImpact fetal growth