Hepatitis C Virus Indirectly Disrupts DNA Damage-Induced p53 Responses by Activating Protein Kinase R
Mitchell JK, Midkiff BR, Israelow B, Evans MJ, Lanford RE, Walker CM, Lemon SM, McGivern DR. Hepatitis C Virus Indirectly Disrupts DNA Damage-Induced p53 Responses by Activating Protein Kinase R. MBio 2017, 8: e00121-17. PMID: 28442604, PMCID: PMC5405228, DOI: 10.1128/mbio.00121-17.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDisease Models, AnimalEIF-2 KinaseHep G2 CellsHepacivirusHepatitis CHost-Pathogen InteractionsHumansPan troglodytesTumor Suppressor Protein p53ConceptsHepatitis C virusHCV infectionC virusProtein kinase RHCV replicationLiver cancerHost responseHepatocellular carcinogenesisP53 functionHCV protein expressionHCV RNA replicationP53 responseLiver-derived HepG2 cellsDNA damageOncogenic RNA virusesInfectious causesChronic infectionRNA replicationPhosphorylated protein kinase RActivation of p53Viral activationInfectionMicroRNA-122P53-mediated responseP53 inhibition