1990
Acute Effects of Typical and Atypical Antipsychotic Drugs on the Release of Dopamine from Prefrontal Cortex, Nucleus Accumbens, and Striatum of the Rat: An In Vivo Microdialysis Study
Moghaddam B, Bunney B. Acute Effects of Typical and Atypical Antipsychotic Drugs on the Release of Dopamine from Prefrontal Cortex, Nucleus Accumbens, and Striatum of the Rat: An In Vivo Microdialysis Study. Journal Of Neurochemistry 1990, 54: 1755-1760. PMID: 1969939, DOI: 10.1111/j.1471-4159.1990.tb01230.x.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexOutflow of dopamineRelease of dopamineNucleus accumbensAntipsychotic drugsPrefrontal cortexAcute effectsExtracellular levelsAtypical antipsychotic drug clozapineVivo microdialysis studyAtypical antipsychotic drugsEffects of sulpirideEffects of haloperidolAntipsychotic drug clozapineMicrodialysis studyVivo microdialysisDrug clozapineHaloperidolStriatumAccumbensCortexSulpirideExtracellular concentrationDopamineDrugsUtilization of microdialysis for assessing the release of mesotelencephalic dopamine following clozapine and other antipsychotic drugs
Moghaddam B, Bunney B. Utilization of microdialysis for assessing the release of mesotelencephalic dopamine following clozapine and other antipsychotic drugs. Progress In Neuro-Psychopharmacology And Biological Psychiatry 1990, 14: s51-s57. PMID: 2097674, DOI: 10.1016/0278-5846(90)90086-v.Peer-Reviewed Original ResearchConceptsAntipsychotic drugsDopamine systemNigrostriatal dopamine systemEffects of clozapineRelease of dopamineRat. 2Mesocortical dopamine systemAcute administrationVivo microdialysisMesotelencephalic systemNucleus accumbensPrefrontal effectPrefrontal cortexClozapineExtracellular concentrationDopamineHaloperidolMicrodialysisDrugsSulpirideMesolimbicStriatumAccumbensCortex
1988
Intracellular studies of dopamine neurons in vitro: pacemakers modulated by dopamine
Silva N, Bunney B. Intracellular studies of dopamine neurons in vitro: pacemakers modulated by dopamine. European Journal Of Pharmacology 1988, 149: 307-315. PMID: 3409955, DOI: 10.1016/0014-2999(88)90661-9.Peer-Reviewed Original ResearchConceptsSensitive neuronsInput resistanceAdministration of DADA-sensitive neuronsSelective D2 antagonistPacemaker-like activityHigh input resistanceZona compactaDA actionD2 antagonistDopamine neuronsIntracellular recordingsFiring rateIntracellular studyNeuronsReversal potentialTissue slicesDopamineHyperpolarizationSulpirideAntagonistCompactaAdministration