2012
Bursting as a source of non‐linear determinism in the firing patterns of nigral dopamine neurons
Jeong J, Shi W, Hoffman R, Oh J, Gore JC, Bunney BS, Peterson BS. Bursting as a source of non‐linear determinism in the firing patterns of nigral dopamine neurons. European Journal Of Neuroscience 2012, 36: 3214-3223. PMID: 22831464, PMCID: PMC3490015, DOI: 10.1111/j.1460-9568.2012.08238.x.Peer-Reviewed Original ResearchConceptsNigral dopamine neuronsDA neuronsFiring patternsComplex firing patternsDopamine neuronsBursting activityChloral hydrate-anesthetized ratsHalothane-anesthetized ratsRat substantia nigraReward-related learningSubstantia nigraPhasic burstsFiring activityNeuronsBursting neuronsRatsStochastic firing patternsVivoNon-linear deterministic structureActivityNigra
2007
Oscillatory firing of dopamine neurons: Differences between cells in the substantia nigra and ventral tegmental area
Zhang D, Yang S, Jin G, Bunney B, Shi W. Oscillatory firing of dopamine neurons: Differences between cells in the substantia nigra and ventral tegmental area. Synapse 2007, 62: 169-175. PMID: 18081182, DOI: 10.1002/syn.20479.Peer-Reviewed Original ResearchConceptsVentral tegmental areaDA neuronsSubstantia nigraDopamine neuronsTegmental areaSlow oscillationsChloral hydrate-anesthetized ratsSN DA neuronsVTA DA neuronsDegree of burstingVariability of firingAfferent inputAdjacent substantia nigraOscillatory firingFiring rateNeuronsNeuronal oscillationsNigraCellsFiringRatsBrainImportant role
1996
Effects of Lesions in the Medial Prefrontal Cortex on the Activity of Midbrain Dopamine Neurons
Shim S, Bunney B, Shi W. Effects of Lesions in the Medial Prefrontal Cortex on the Activity of Midbrain Dopamine Neurons. Neuropsychopharmacology 1996, 15: 437-441. PMID: 8914116, DOI: 10.1016/s0893-133x(96)00052-8.Peer-Reviewed Original ResearchConceptsVentral tegmental areaDA neuronsPrefrontal cortexSubstantia nigraPFC lesionsBursting activityFiring rateActive DA cellsSN DA neuronsActive DA neuronsMidbrain dopamine neuronsSingle-unit recordingsMedial prefrontal cortexDA cellsDopamine neuronsTegmental areaLocal injectionIbotenic acidUnit recordingsLesionsSame lesionNeuronsRatsActivityCortex
1990
Neurotensin attenuates dopamine D2 agonist quinpirole-induced inhibition of midbrain dopamine neurons
Shi W, Bunney B. Neurotensin attenuates dopamine D2 agonist quinpirole-induced inhibition of midbrain dopamine neurons. Neuropharmacology 1990, 29: 1095-1097. PMID: 1982340, DOI: 10.1016/0028-3908(90)90119-c.Peer-Reviewed Original ResearchConceptsD2 agonistDA cellsSingle-unit recording techniquesMidbrain DA neuronsCentral DA systemsDopamine D2 agonistMidbrain dopamine neuronsSpecific D2 agonistDA neuronsIntracerebroventricular administrationDopamine neuronsSpontaneous activityDA systemInhibitory effectRecording techniquesAgonistsNeuronsBiochemical studiesCellsQuinpiroleNeurotensinRatsAdministration
1988
The effects of pertussis toxin on autoreceptor-mediated inhibition of dopamine synthesis in the rat striatum.
Bean A, Shepard P, Bunney B, Nestler E, Roth R. The effects of pertussis toxin on autoreceptor-mediated inhibition of dopamine synthesis in the rat striatum. Molecular Pharmacology 1988, 34: 715-8. PMID: 2974120.Peer-Reviewed Original ResearchConceptsPertussis toxin injectionDopamine synthesisToxin injectionDopamine autoreceptorsRat striatumPertussis toxinAutoreceptor-mediated inhibitionDopamine agonist apomorphineG proteinsAgonist apomorphineUnilateral administrationControl ratsSystemic administrationStriatal tissueEffects of activationAutoreceptorsApomorphineStriatumRatsAdministrationInjectionToxinActivationStriataAgonists
1985
Firing properties of substantia nigra dopaminergic neurons in freely moving rats
Freeman A, Meltzer L, Bunney B. Firing properties of substantia nigra dopaminergic neurons in freely moving rats. Life Sciences 1985, 36: 1983-1994. PMID: 3990520, DOI: 10.1016/0024-3205(85)90448-5.Peer-Reviewed Original ResearchConceptsPutative DA neuronsDA neuronsDopaminergic neuronsParalyzed ratsSubstantia nigra dopaminergic neuronsFiring patternsPutative dopaminergic neuronsNigrostriatal DA systemNigra dopaminergic neuronsApomorphine-induced inhibitionSingle spike activityPattern of firingSingle-unit recordingsDegree of burstSubstantia nigraDA cellsElectrophysiological characteristicsUnit recordingsSpike activityFiring propertiesRatsFiring rateNeuronsDA systemCells