1989
Pharmacological characterization of the receptor mediating electrophysiological responses to dopamine in the rat medial prefrontal cortex: a microiontophoretic study.
Sesack S, Bunney B. Pharmacological characterization of the receptor mediating electrophysiological responses to dopamine in the rat medial prefrontal cortex: a microiontophoretic study. Journal Of Pharmacology And Experimental Therapeutics 1989, 248: 1323-33. PMID: 2564893.Peer-Reviewed Original ResearchConceptsRat medial prefrontal cortexMedial prefrontal cortexGamma-aminobutyric acidD2-selective agonistsSelective agonistPrefrontal cortexPFC neuronsInhibitory effectSelective antagonistExtracellular single-unit recordingsD1-selective agonistsSingle-unit recordingsD1-selective antagonistD2-selective antagonistWeak antagonist activityMicroiontophoretic studyMicroiontophoretic techniquesSuperficial laminaeIontophoretic applicationLY171555Pharmacological characterizationInhibitory responsesMajority of cellsPharmacological characteristicsPharmacological profile
1984
The control of firing pattern in nigral dopamine neurons: single spike firing
Grace A, Bunney B. The control of firing pattern in nigral dopamine neurons: single spike firing. Journal Of Neuroscience 1984, 4: 2866-2876. PMID: 6150070, PMCID: PMC6564731, DOI: 10.1523/jneurosci.04-11-02866.1984.Peer-Reviewed Original ResearchConceptsSingle-spike firingDA cellsSlow depolarizationCalcium chelator EGTADopamine neuronsSpike firingCalcium-activated potassium conductanceActive DA cellsNigral dopamine neuronsChelator EGTAVivo intracellular recordingsDA neuronsDepolarization inactivationMembrane potentialIontophoretic applicationTrain of spikesIntracellular recordingsExcitatory substancesIntracellular injectionCalcium entryAction potentialsAfterhyperpolarizationPotassium conductanceRate of riseNeurons