1984
The effects of phencyclidine and N-allylnormetazocine on midbrain dopamine neuronal activity
Freeman A, Bunney B. The effects of phencyclidine and N-allylnormetazocine on midbrain dopamine neuronal activity. European Journal Of Pharmacology 1984, 104: 287-293. PMID: 6094217, DOI: 10.1016/0014-2999(84)90404-7.Peer-Reviewed Original ResearchConceptsDA neuronsNeuronal activityN-allylnormetazocineMidbrain dopamine neuronal activitySingle-unit recording techniquesSubstantia nigra zona compactaFiring rateA10 DA neuronsDopamine neuronal activitySigma receptor agonistsMidbrain dopamine neuronsBaseline firing rateEffects of phencyclidineWeak inhibitory actionExcitatory effectsZona compactaHaloperidol pretreatmentDopamine neuronsReceptor agonistBiphasic effectInhibitory actionNeuronsRecording techniquesPhencyclidineDrugs
1980
Effects of baclofen on nigral dopaminergic cell activity following acute and chronic haloperidol treatment
Grace A, Bunney B. Effects of baclofen on nigral dopaminergic cell activity following acute and chronic haloperidol treatment. Brain Research Bulletin 1980, 5: 537-543. DOI: 10.1016/0361-9230(80)90087-8.Peer-Reviewed Original ResearchChronic haloperidol treatmentDopaminergic cell activityEffects of baclofenHaloperidol treatmentLow dosesExtracellular single-unit recording techniquesNeuroleptic-induced side effectsRat nigral dopaminergic neuronsCell activitySingle-unit recording techniquesInhibitory effectNigral DA cellsSingle low dosesNigral dopaminergic neuronsTreatment of spasticityAction of baclofenDose-response curveMechanism of actionDepolarization inactivationDopaminergic neuronsHaloperidol pretreatmentDA cellsPossible efficacyNigral inputsBaclofen