2007
Clozapine Blocks D-Amphetamine-Induced Excitation of Dopamine Neurons in the Ventral Tegmental Area
Shi W, Zhang X, Pun C, Bunney B. Clozapine Blocks D-Amphetamine-Induced Excitation of Dopamine Neurons in the Ventral Tegmental Area. Neuropsychopharmacology 2007, 32: 1922-1928. PMID: 17299514, DOI: 10.1038/sj.npp.1301334.Peer-Reviewed Original ResearchConceptsD2-like receptorsDA neuronsVentral tegmental areaD-amphetamineDA receptorsExcitatory effectsTegmental areaΑ1 receptor antagonist prazosinAtypical antipsychotic drug clozapineChloral hydrate-anesthetized ratsTypical antipsychotic drug haloperidolCentral dopamine transmissionCurrent antipsychotic drugsReceptor antagonist prazosinAntipsychotic drug haloperidolAntipsychotic drug clozapineAntagonist prazosinExcitatory pathwaysDA transmissionDopamine neuronsΑ1 receptorsSystemic administrationAntipsychotic drugsExcitatory inputsIncomplete blockade
2000
Dual Effects of d-Amphetamine on Dopamine Neurons Mediated by Dopamine and Nondopamine Receptors
Shi W, Pun C, Zhang X, Jones M, Bunney B. Dual Effects of d-Amphetamine on Dopamine Neurons Mediated by Dopamine and Nondopamine Receptors. Journal Of Neuroscience 2000, 20: 3504-3511. PMID: 10777813, PMCID: PMC6773133, DOI: 10.1523/jneurosci.20-09-03504.2000.Peer-Reviewed Original ResearchConceptsD2-like receptorsD-amphetamineDA cellsSelective D2 antagonist racloprideVivo single-unit recordingsFiring rateAlpha1-antagonist prazosinAlpha2 antagonist idazoxanAlpha-antagonist phenoxybenzamineD2 antagonist racloprideDA cell firingSingle-unit recordingsRelated psychostimulantsAntagonist idazoxanAntagonist phenoxybenzamineDA receptorsAntagonist prazosinAntagonist racloprideExcitatory effectsAlpha1 receptorsDopamine neuronsDopamine releaseCell firingInhibitory effectReceptors
1992
Actions of Neurotensin: A Review of the Electrophysiological Studiesa
SHI W, BUNNEY B. Actions of Neurotensin: A Review of the Electrophysiological Studiesa. Annals Of The New York Academy Of Sciences 1992, 668: 129-145. PMID: 1463269, DOI: 10.1111/j.1749-6632.1992.tb27345.x.Peer-Reviewed Original ResearchMeSH KeywordsNeurotensinConceptsExcitatory effectsDA cellsModulatory effectsDA receptor blockadeDirect postsynaptic effectAction of neurotensinGlutamate-induced excitationMidbrain DA cellsMembrane conductancePostsynaptic effectsReceptor blockadeDepolarization inactivationNT receptorsCell activityFiring rateSame receptorNeuromedin NSudden cessationHigh concentrationsProtein kinase CBasal activityToxic effectsInhibitionNeurotensinReceptors
1991
Effects of neurotensin on midbrain dopamine neurons: Are they mediated by formation of a neurotensin—dopamine complex?
Shi W, Bunney B. Effects of neurotensin on midbrain dopamine neurons: Are they mediated by formation of a neurotensin—dopamine complex? Synapse 1991, 9: 157-164. PMID: 1776128, DOI: 10.1002/syn.890090302.Peer-Reviewed Original ResearchConceptsEffects of neurotensinNeurotensin receptorsDopamine neuronsDopamine cellsCell activitySingle-unit recording techniquesFiring rateMidbrain dopamine neuron activityAction of neurotensinBasal firing rateDopamine receptor blockadeDopamine-induced inhibitionDopamine neuron activityMidbrain dopamine neuronsReceptor blockadeDepolarization inactivationExcitatory effectsNative neurotensinBrain slicesNeuron activityNeurotensinNeurotensin analoguesSame receptorRecording techniquesReceptors
1987
Electrophysiological studies on the specificity of the cholecystokinin antagonist proglumide
Chiodo L, Freeman A, Bunney B. Electrophysiological studies on the specificity of the cholecystokinin antagonist proglumide. Brain Research 1987, 410: 205-211. PMID: 3036308, DOI: 10.1016/0006-8993(87)90317-9.Peer-Reviewed Original ResearchConceptsExcitatory effectsInhibitory effectA9 DA neuronsCCK receptor blockadeSelective CCK antagonistsMidbrain dopamine cellsPrefrontal cortical neuronsInhibitory potencyDA neuronsReceptor blockadeChronic treatmentSensorimotor cortexCCK antagonistsC-terminal octapeptideDA cellsSubstance PAPO effectsCortical neuronsDopamine cellsIntravenous administrationSelective antagonistRat CNSProglumideElectrophysiological studiesCholecystokinin
1984
The effects of phencyclidine and N-allylnormetazocine on midbrain dopamine neuronal activity
Freeman A, Bunney B. The effects of phencyclidine and N-allylnormetazocine on midbrain dopamine neuronal activity. European Journal Of Pharmacology 1984, 104: 287-293. PMID: 6094217, DOI: 10.1016/0014-2999(84)90404-7.Peer-Reviewed Original ResearchConceptsDA neuronsNeuronal activityN-allylnormetazocineMidbrain dopamine neuronal activitySingle-unit recording techniquesSubstantia nigra zona compactaFiring rateA10 DA neuronsDopamine neuronal activitySigma receptor agonistsMidbrain dopamine neuronsBaseline firing rateEffects of phencyclidineWeak inhibitory actionExcitatory effectsZona compactaHaloperidol pretreatmentDopamine neuronsReceptor agonistBiphasic effectInhibitory actionNeuronsRecording techniquesPhencyclidineDrugs
1979
Paradoxical GABA excitation of nigral dopaminergic cells: Indirect mediation through reticulata inhibitory neurons
Grace A, Bunney B. Paradoxical GABA excitation of nigral dopaminergic cells: Indirect mediation through reticulata inhibitory neurons. European Journal Of Pharmacology 1979, 59: 211-218. PMID: 527646, DOI: 10.1016/0014-2999(79)90283-8.Peer-Reviewed Original ResearchConceptsZona reticulataGABA agonistsGABAergic inputsZona compactaSubstantia nigraLow dosesCell activitySingle-unit recording techniquesNigral dopaminergic cellsInhibitory GABAergic inputMeans of microiontophoresisPopulations of neuronsCell firing rateGABA excitationExcitatory effectsDopaminergic neuronsDopaminergic cellsInhibitory neuronsSame doseElectrophysiological studiesNeuron activityZR cellsFiring rateNeuronsAgonists