1991
Repetitive firing properties of putative dopamine-containing neurons in vitro: regulation by an apamin-sensitive Ca2+-activated K+ conductance
Shepard P, Bunney B. Repetitive firing properties of putative dopamine-containing neurons in vitro: regulation by an apamin-sensitive Ca2+-activated K+ conductance. Experimental Brain Research 1991, 86: 141-150. PMID: 1756785, DOI: 10.1007/bf00231048.Peer-Reviewed Original ResearchConceptsAction potentialsPutative dopamine-containing neuronsEffects of apaminDopamine-containing neuronsIntracellular recording techniquesPost-spike afterhyperpolarizationRepetitive firing propertiesTypes of Ca2Apamin-sensitive Ca2Adaptive neuronal responsesZona compactaSubstantia nigraBath applicationInhibitory periodNeuronal responsesAfterhyperpolarizationApaminFiring propertiesRecording techniquesCellular mechanismsElectroresponsive propertiesFrequency adaptationSelective inhibitorInterspike intervalsNeurons
1988
Effects of apamin on the discharge properties of putative dopamine-containing neurons in vitro
Shepard P, Bunney B. Effects of apamin on the discharge properties of putative dopamine-containing neurons in vitro. Brain Research 1988, 463: 380-384. PMID: 3196925, DOI: 10.1016/0006-8993(88)90414-3.Peer-Reviewed Original ResearchConceptsDopamine-containing neuronsPutative dopamine-containing neuronsEffects of apaminCalcium-activated potassium conductanceCalcium-activated potassium channelsBrain slice preparationApamin administrationSubstantia nigraSlice preparationNeuronal excitabilityBursting activityPotassium conductancePotassium channelsNeuronsSelective inhibitorApaminRegular activitiesExcitabilityAdministrationNigra
1987
Population response of midbrain dopaminergic neurons to neuroleptics: further studies on time course and nondopaminergic neuronal influences
Chiodo L, Bunney B. Population response of midbrain dopaminergic neurons to neuroleptics: further studies on time course and nondopaminergic neuronal influences. Journal Of Neuroscience 1987, 7: 629-633. PMID: 2881987, PMCID: PMC6569064, DOI: 10.1523/jneurosci.07-03-00629.1987.Peer-Reviewed Original ResearchConceptsDepolarization-induced inactivationFiring rateDopaminergic neuronsDopamine receptor agonist apomorphineMonths' continuous treatmentAcute oral administrationBasal firing rateActive DA neuronsReceptor agonist apomorphineA10 dopaminergic neuronsActive dopamine neuronsClassical antipsychotic drugsDopamine-containing neuronsPresence of haloperidolHr of administrationLong-term treatmentMidbrain dopaminergic neuronsCholecystokinin receptor antagonistAge-matched controlsHaloperidol resultsA10 regionDA neuronsAcute administrationAgonist apomorphineNeuroleptic haloperidol
1981
Peptide-monoamine coexistence: Studies of the actions of cholecystokinin-like peptide on the electrical activity of midbrain dopamine neurons
Skirboll L, Grace A, Hommer D, Rehfeld J, Goldstein M, Hökfelt T, Bunney B. Peptide-monoamine coexistence: Studies of the actions of cholecystokinin-like peptide on the electrical activity of midbrain dopamine neurons. Neuroscience 1981, 6: 2111-2124. PMID: 6120481, DOI: 10.1016/0306-4522(81)90002-6.Peer-Reviewed Original ResearchConceptsCholecystokinin-like peptidesVentral tegmental areaDopaminergic neuronsFiring rateSubstantia nigraTegmental areaDopaminergic cellsExtracellular single-unit recording techniquesMidbrain dopamine-containing neuronsSingle-unit recording techniquesDopamine-containing neuronsBrain dopaminergic systemDopamine-rich areasMidbrain dopamine neuronsDepolarization inactivationResponsive neuronsDopamine neuronsDopaminergic systemComparable dosesTyrosine hydroxylaseCholecystokininBursting activityNeuronsImmunocytochemical techniquesRecording techniques
1980
Nigral Dopamine Neurons: Intracellular Recording and Identification with L-Dopa Injection and Histofluorescence
Grace A, Bunney B. Nigral Dopamine Neurons: Intracellular Recording and Identification with L-Dopa Injection and Histofluorescence. Science 1980, 210: 654-656. PMID: 7433992, DOI: 10.1126/science.7433992.Peer-Reviewed Original ResearchConceptsL-DOPA injectionIntracellular recordingsAntidromic conduction velocitiesPutative dopaminergic neuronsDopamine-containing neuronsRat substantia nigraAntidromic activationDopaminergic neuronsSubstantia nigraSlow depolarizationBurst firingFluorescence histochemistryConduction velocityFast potentialsNeuronsExtracellular spikesInjectionHistofluorescenceRecordingsNigra