2007
Clozapine Blocks D-Amphetamine-Induced Excitation of Dopamine Neurons in the Ventral Tegmental Area
Shi W, Zhang X, Pun C, Bunney B. Clozapine Blocks D-Amphetamine-Induced Excitation of Dopamine Neurons in the Ventral Tegmental Area. Neuropsychopharmacology 2007, 32: 1922-1928. PMID: 17299514, DOI: 10.1038/sj.npp.1301334.Peer-Reviewed Original ResearchConceptsD2-like receptorsDA neuronsVentral tegmental areaD-amphetamineDA receptorsExcitatory effectsTegmental areaΑ1 receptor antagonist prazosinAtypical antipsychotic drug clozapineChloral hydrate-anesthetized ratsTypical antipsychotic drug haloperidolCentral dopamine transmissionCurrent antipsychotic drugsReceptor antagonist prazosinAntipsychotic drug haloperidolAntipsychotic drug clozapineAntagonist prazosinExcitatory pathwaysDA transmissionDopamine neuronsΑ1 receptorsSystemic administrationAntipsychotic drugsExcitatory inputsIncomplete blockade
2000
Dual Effects of d-Amphetamine on Dopamine Neurons Mediated by Dopamine and Nondopamine Receptors
Shi W, Pun C, Zhang X, Jones M, Bunney B. Dual Effects of d-Amphetamine on Dopamine Neurons Mediated by Dopamine and Nondopamine Receptors. Journal Of Neuroscience 2000, 20: 3504-3511. PMID: 10777813, PMCID: PMC6773133, DOI: 10.1523/jneurosci.20-09-03504.2000.Peer-Reviewed Original ResearchConceptsD2-like receptorsD-amphetamineDA cellsSelective D2 antagonist racloprideVivo single-unit recordingsFiring rateAlpha1-antagonist prazosinAlpha2 antagonist idazoxanAlpha-antagonist phenoxybenzamineD2 antagonist racloprideDA cell firingSingle-unit recordingsRelated psychostimulantsAntagonist idazoxanAntagonist phenoxybenzamineDA receptorsAntagonist prazosinAntagonist racloprideExcitatory effectsAlpha1 receptorsDopamine neuronsDopamine releaseCell firingInhibitory effectReceptors
1999
Endogenous DA‐mediated feedback inhibition of DA neurons: Involvement of both D1‐ and D2‐like receptors
Shi W, Pun C, Smith P, Bunney B. Endogenous DA‐mediated feedback inhibition of DA neurons: Involvement of both D1‐ and D2‐like receptors. Synapse 1999, 35: 111-119. PMID: 10611636, DOI: 10.1002/(sici)1098-2396(200002)35:2<111::aid-syn3>3.0.co;2-7.Peer-Reviewed Original ResearchConceptsDA neuronsLike receptorsDA cellsEndogenous DAChloral hydrate-anesthetized ratsNigral DA cellsD2-like receptorsSingle-unit recordingsCerveau isolé preparationFeedback inhibitionParkinsonian animalsAntagonist racloprideAntagonist SCH23390DA releaseEndogenous dopamineD-amphetamineParkinson's diseaseUnit recordingsSCH23390Receptor activationBaseline activityReceptorsChloral hydrateNeuronsConcurrent activationOpposite modulation of cortical N-methyl-d-aspartate receptor-mediated responses by low and high concentrations of dopamine
Zheng P, Zhang X, Bunney B, Shi W. Opposite modulation of cortical N-methyl-d-aspartate receptor-mediated responses by low and high concentrations of dopamine. Neuroscience 1999, 91: 527-535. PMID: 10366010, DOI: 10.1016/s0306-4522(98)00604-6.Peer-Reviewed Original ResearchMeSH Keywords1-Methyl-3-isobutylxanthine2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepineAlpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidAnimalsBenzazepinesDizocilpine MaleateDopamineDopamine AgonistsDopamine AntagonistsDose-Response Relationship, DrugExcitatory Amino Acid AntagonistsIn Vitro TechniquesMaleMembrane PotentialsPrefrontal CortexPyramidal CellsQuinoxalinesQuinpiroleRatsRats, Sprague-DawleyReceptors, N-Methyl-D-AspartateConceptsN-methyl-D-aspartate functionN-methyl-D-aspartate currentsN-methyl-D-aspartate (NMDA) receptor-mediated transmissionN-methyl-D-aspartate receptor-mediated responsesN-methyl-D-aspartate receptorsHigh concentrations dopamineReceptor-mediated transmissionD2 agonist quinpiroleD1 agonist SKF38393D1-like receptorsD-aspartate antagonistGlutamate-mediated neurotransmissionD2-like receptorsPresence of tetrodotoxinEffects of dopamineReceptor-mediated responsesWhole-cell recordingsD-aspartate agonistMedial prefrontal cortexBrief local applicationDizocilpine maleateAgonist SKF38393Concentration of dopamineCortical dopamineGlutamate transmission
1997
D1–D2 Interaction in Feedback Control of Midbrain Dopamine Neurons
Shi W, Smith P, Pun C, Millet B, Bunney B. D1–D2 Interaction in Feedback Control of Midbrain Dopamine Neurons. Journal Of Neuroscience 1997, 17: 7988-7994. PMID: 9315916, PMCID: PMC6793911, DOI: 10.1523/jneurosci.17-20-07988.1997.Peer-Reviewed Original ResearchConceptsD2-like receptorsDA cellsDA autoreceptorsDA neuronsD1 agonistLow dosesDopamine D1-like receptorsD1 inhibitionD1 effectNigral DA cellsMidbrain DA neuronsD2 agonist quinpiroleD1-like receptorsDA receptor subtypesMidbrain dopamine neuronsOnly low dosesDA receptorsEndogenous DAAgonist quinpiroleD2 agonistIntranigral applicationDopamine neuronsReceptor subtypesRat preparationTarget neurons
1995
Ritanserin, a 5-HT2A/2C antagonist, reverses direct dopamine agonist-induced inhibition of midbrain dopamine neurons.
Shi W, Nathaniel P, Bunney B. Ritanserin, a 5-HT2A/2C antagonist, reverses direct dopamine agonist-induced inhibition of midbrain dopamine neurons. Journal Of Pharmacology And Experimental Therapeutics 1995, 274: 735-40. PMID: 7636736.Peer-Reviewed Original ResearchConceptsEffects of ritanserinBasal firing rateDA autoreceptorsDA neuronsDA agonistsP-chlorophenylalanineSubstantia nigra DA neuronsSingle-unit recording techniquesChloral hydrate-anesthetized ratsFiring rateDA agonist quinpiroleDirect DA agonistsIndirect DA agonistPostsynaptic D2 receptorsExtrapyramidal side effectsD2-like receptorsSignificant therapeutic effectAgonist-induced inhibitionMidbrain dopamine neuronsMidbrain dopamine systemAgonist quinpiroleDA antagonistsMDL 100907Receptor antagonistDopamine neurons