2005
Nicotine induces mitogen-activated protein kinase dependent vascular smooth muscle cell migration
Di Luozzo G, Pradhan S, Dhadwal AK, Chen A, Ueno H, Sumpio BE. Nicotine induces mitogen-activated protein kinase dependent vascular smooth muscle cell migration. Atherosclerosis 2005, 178: 271-277. PMID: 15694934, DOI: 10.1016/j.atherosclerosis.2004.09.017.Peer-Reviewed Original ResearchConceptsVascular smooth muscle cell migrationSmooth muscle cell migrationMuscle cell migrationInhibitors of p38VSMC migrationMitogen-activated protein kinaseEndothelial cellsDevelopment of atherosclerosisEffects of nicotineCell migrationWestern blotting methodInjury modelVascular endotheliumCigarette smokeBoyden chamber chemotaxis assaysAortic VSMCsChemotactic effectMAPKs p38NicotineChemoattractant moleculesChemotaxis assaysCellular mechanismsUltrastructural changesVSMCP44/42 activation
2000
Functional parathyroid hormone receptors are present in an umbilical vein endothelial cell line
Isales C, Sumpio B, Bollag R, Zhong Q, Ding K, Du W, Rodriguez-Commes J, Lopez R, Rosales O, Gasalla-Herraiz J, McCarthy R, Barrett P. Functional parathyroid hormone receptors are present in an umbilical vein endothelial cell line. AJP Endocrinology And Metabolism 2000, 279: e654-e662. PMID: 10950835, DOI: 10.1152/ajpendo.2000.279.3.e654.Peer-Reviewed Original ResearchMeSH KeywordsCalciumCell LineChromatography, High Pressure LiquidCyclic AMPEndothelin-1Endothelium, VascularFluorescent DyesFura-2Glyceraldehyde-3-Phosphate DehydrogenasesHumansInositol PhosphatesParathyroid HormoneReceptors, Parathyroid HormoneReverse Transcriptase Polymerase Chain ReactionRNA, MessengerSignal TransductionThymidineUmbilical VeinsConceptsParathyroid hormoneUmbilical vein endothelial cell lineParathyroid hormone receptorEndothelial cell lineHormone receptorsVascular smooth muscle relaxationEndothelin-1 secretionSmooth muscle relaxationVascular smooth muscleHuman umbilical vein endothelial cell lineCell linesCellular cAMP contentPossible direct effectPeptide receptor mRNAEndothelium-derived cellsBlood pressureContinuous infusionMuscle relaxationIntracellular calciumSmooth muscleReceptor mRNAHormone exposureVascular endotheliumEndothelial cellsCAMP content
1999
Localization of Atherosclerosis: Role of Hemodynamics
Frangos S, Gahtan V, Sumpio B. Localization of Atherosclerosis: Role of Hemodynamics. JAMA Surgery 1999, 134: 1142-1149. PMID: 10522862, DOI: 10.1001/archsurg.134.10.1142.Peer-Reviewed Original ResearchConceptsEndothelial cell structureCoronary arteryAortic archRisk factorsAbdominal aortaChronic diseasesVascular endotheliumCircumferential strainRole of hemodynamicsLesionsHemodynamic forcesCyclic circumferential strainMajor branchesSusceptible sitesAtherosclerosisArteryAortaHemodynamicsAtherogenesisEndotheliumDisease
1993
Common pathway of endothelial-leukocyte interaction in shock, ischemia, and reperfusion
McMillen M, Huribal M, Sumpio B. Common pathway of endothelial-leukocyte interaction in shock, ischemia, and reperfusion. The American Journal Of Surgery 1993, 166: 557-562. PMID: 8238752, DOI: 10.1016/s0002-9610(05)81153-5.Peer-Reviewed Original ResearchConceptsBlood flowVascular endotheliumSignificant organ dysfunctionImpaired blood flowEndothelial-leukocyte interactionsRestoration of functionOrgan dysfunctionReperfusion injuryInflammatory cellsIschemia resultsInflammatory responseLeukocyte adherenceFurther injuryNeutrophil interactionsOxygen deliveryCurrent evidenceCellular injuryIschemiaEndothelial cellsInjuryCommon pathwayEndotheliumCurrent literatureCellular functionsAnaerobic mechanismsEndothelin-Stimulated Human Monocytes Produce Prostaglandin E2 but Not Leukotriene B4
McMillen M, Huribal M, Kumar R, Sumpio B. Endothelin-Stimulated Human Monocytes Produce Prostaglandin E2 but Not Leukotriene B4. Journal Of Surgical Research 1993, 54: 331-335. PMID: 8392650, DOI: 10.1006/jsre.1993.1053.Peer-Reviewed Original ResearchConceptsProstaglandin E2Pg/Human monocytesPost-traumatic immunosuppressionMonocytes/macrophagesBacterial lipopolysaccharide (LPS) stimulationEndothelin increaseM endothelinInterleukin-6Immune functionLeukotriene B4PGE2 productionVascular endotheliumEndothelinLipopolysaccharide (LPS) stimulationInjuryMonocytesAcid peptideE2B4HrActivationImmunosuppressionIschemiaMajor role