1987
Mitochondrial Respiratory and Calcium Studies
SUMPIO B, BAUE A, CHAUDRY I. Mitochondrial Respiratory and Calcium Studies. Annals Of Surgery 1987, 206: 655-660. PMID: 3499878, PMCID: PMC1493310, DOI: 10.1097/00000658-198711000-00017.Peer-Reviewed Original ResearchConceptsRespiratory control ratioVerapamil pretreatmentTotal tissue Ca2Tissue ATP levelsCyA-induced nephrotoxicityCyA treatmentPharmacologic regimenRenal functionMitochondrial respiratory functionSimultaneous administrationCalcium studiesRespiratory functionKrebs bufferCortical mitochondriaMumol/Tissue Ca2Rat kidneyADP/O ratioCyANephrotoxicityATP levelsControl ratioVerapamilMitochondrial respiratoryCa2
1985
Reduction of the drug-induced nephrotoxicity by ATP-MgCl2. II. Effects on gentamicin-treated isolated perfused kidneys
Sumpio B, Chaudry I, Baue A. Reduction of the drug-induced nephrotoxicity by ATP-MgCl2. II. Effects on gentamicin-treated isolated perfused kidneys. Journal Of Surgical Research 1985, 38: 438-445. PMID: 3872964, DOI: 10.1016/0022-4804(85)90059-9.Peer-Reviewed Original ResearchConceptsDrug-induced nephrotoxicityGlomerular filtration rateRenal perfusate flowATP-MgCl2Filtration ratePerfusate flowMM ATP-MgCl2Prevention of nephrotoxicityGentamicin-induced nephrotoxicitySignificant clinical problemNon-pulsatile perfusionIsolated kidney preparationMin of perfusionHr of perfusionDose-dependent mannerTubular absorptionUrinary flowGentamicin treatmentProtein reabsorptionClinical problemNephrotoxicityPerfusate concentrationFractional clearanceClearance periodSodium absorption
1984
Urinary excretion of interferon, albumin, and beta 2-microglobulin during interferon treatment.
Sumpio BE, Ernstoff MS, Kirkwood JM. Urinary excretion of interferon, albumin, and beta 2-microglobulin during interferon treatment. Cancer Research 1984, 44: 3599-603. PMID: 6378373.Peer-Reviewed Original ResearchConceptsInterferon therapyUrinary excretionInterferon activityPhase I trialSerum interferon activityUrinary betaInterferon administrationI trialSignificant nephrotoxicityTubular lesionsUrinary levelsInterferon treatmentHighest dosing levelDosing levelsTherapyInterferonExcretionTreatmentLow affinityAlbuminBetaNephrotoxicityPatientsLesionsPharmacokinetics