1987
Treatment with verapamil and adenosine triphosphate-MgCl2 reduces cyclosporine nephrotoxicity.
Sumpio B, Baue A, Chaudry I. Treatment with verapamil and adenosine triphosphate-MgCl2 reduces cyclosporine nephrotoxicity. Surgery 1987, 101: 315-22. PMID: 2950608.Peer-Reviewed Original ResearchConceptsGlomerular filtration rateRenal perfusate flowTubular absorptionPerfusate flowUrine outputImmunosuppressive agentsVerapamil pretreatmentClearance periodMicrograms/ATP-MgCl2 treatmentControl clearance periodsUse of cyclosporineCombination of verapamilSerious side effectsTissue ATP levelsEffects of adenosineCyA treatmentCyA nephrotoxicityCyclosporine nephrotoxicityVerapamil treatmentTubular functionRenal flowNephrotoxic potentialFiltration rateATP-MgCl2Comparison of effects of ATP-MgCl2 and adenosine-MgCl2 on renal function following ischemia
Sumpio BE, Hull MJ, Baue AE, Chaudry IH. Comparison of effects of ATP-MgCl2 and adenosine-MgCl2 on renal function following ischemia. American Journal Of Physiology 1987, 252: r388-r393. PMID: 3492930, DOI: 10.1152/ajpregu.1987.252.2.r388.Peer-Reviewed Original ResearchConceptsRenal functionATP-MgCl2Warm ischemiaATP-MgCl2 treatmentKrebs-HCO3 bufferMM ATP-MgCl2Comparison of effectsNormothermic ischemiaTransient improvementIschemiaSalutary effectsControl valuesUrine samplesFunctional parametersKidneyMajor breakdown productAdenosineTreatmentBreakdown productsMmHgPerfusateMinAdministration
1986
Effects of ATP-MgCl2 and adenosine-MgCl2 administration on intracellular ATP levels in the kidney
Sumpio B, Hull M, Bauer A, Chaudry I. Effects of ATP-MgCl2 and adenosine-MgCl2 administration on intracellular ATP levels in the kidney. Biochimica Et Biophysica Acta 1986, 862: 303-308. PMID: 3778894, DOI: 10.1016/0005-2736(86)90232-4.Peer-Reviewed Original ResearchConceptsATP-MgCl2 administrationColloid oncotic pressureIntracellular ATPATP-MgCl2Exogenous administrationIntracellular ATP levelsRat kidneyOncotic pressureAdministrationTotal intracellular ATPPerfusate solutionKidneyIntracellular accumulationATP levelsAdenine nucleotidesSignificant accumulationATPPerfusate
1985
Accelerated functional recovery of isolated rat kidney with ATP-MgCl2 after warm ischemia
Sumpio B, Chaudry I, Clemens M, Baue A. Accelerated functional recovery of isolated rat kidney with ATP-MgCl2 after warm ischemia. AJP Regulatory Integrative And Comparative Physiology 1985, 248: r752-r752. DOI: 10.1152/ajpregu.1985.248.6.r752-r.Peer-Reviewed Original ResearchReduction of the drug-induced nephrotoxicity by ATP-MgCl2. 1. Effects on the cis-Diamminedichloroplatinum-treated isolated perfused kidneys
Sumpio B, Chaudry I, Baue A. Reduction of the drug-induced nephrotoxicity by ATP-MgCl2. 1. Effects on the cis-Diamminedichloroplatinum-treated isolated perfused kidneys. Journal Of Surgical Research 1985, 38: 429-437. PMID: 3872963, DOI: 10.1016/0022-4804(85)90058-7.Peer-Reviewed Original ResearchConceptsAcute renal failureATP-MgCl2Hr of perfusionCis-DiamminedichloroplatinumNephrotoxic effectsReabsorptive capacityCDDP treatmentRat kidneyATP-MgCl2 treatmentIsolated rat kidneyDrug-induced nephrotoxicityDirect nephrotoxic effectNew therapeutic modalitiesProximal tubule cellsCancer chemotherapeutic agentsCDDP therapyRenal failureMarked diuresisProtein reabsorptionTherapeutic modalitiesTubule cellsChemotherapeutic agentsMicrograms/KidneyMarked inhibitionReduction of the drug-induced nephrotoxicity by ATP-MgCl2. II. Effects on gentamicin-treated isolated perfused kidneys
Sumpio B, Chaudry I, Baue A. Reduction of the drug-induced nephrotoxicity by ATP-MgCl2. II. Effects on gentamicin-treated isolated perfused kidneys. Journal Of Surgical Research 1985, 38: 438-445. PMID: 3872964, DOI: 10.1016/0022-4804(85)90059-9.Peer-Reviewed Original ResearchConceptsDrug-induced nephrotoxicityGlomerular filtration rateRenal perfusate flowATP-MgCl2Filtration ratePerfusate flowMM ATP-MgCl2Prevention of nephrotoxicityGentamicin-induced nephrotoxicitySignificant clinical problemNon-pulsatile perfusionIsolated kidney preparationMin of perfusionHr of perfusionDose-dependent mannerTubular absorptionUrinary flowGentamicin treatmentProtein reabsorptionClinical problemNephrotoxicityPerfusate concentrationFractional clearanceClearance periodSodium absorptionAdenosine Triphosphate—Magnesium Chloride Ameliorates Reperfusion Injury Following Ischemia as Determined by Phosphorus Nuclear Magnetic Resonance
Sumpio B, Chaudry I, Baue A. Adenosine Triphosphate—Magnesium Chloride Ameliorates Reperfusion Injury Following Ischemia as Determined by Phosphorus Nuclear Magnetic Resonance. JAMA Surgery 1985, 120: 233-240. PMID: 3872113, DOI: 10.1001/archsurg.1985.01390260091013.Peer-Reviewed Original ResearchConceptsIntracellular acidosisPerfusate flowATP levelsAdenosine triphosphate-magnesium chlorideRenal ATP levelsMinutes of reperfusionTissue ATP levelsEffects of ischemiaAdenosine triphosphateML/minPostischemic administrationReperfusion injuryRenal ischemiaWarm ischemiaATP-MgCl2ReperfusionIschemiaInorganic phosphate peakIntracellular adenosine triphosphatePi peakRat kidneyAcidosisATP depletionMinutesMagnetic resonance
1984
Accelerated functional recovery of isolated rat kidney with ATP-MgCl2 after warm ischemia
Sumpio BE, Chaudry IH, Clemens MG, Baue AE. Accelerated functional recovery of isolated rat kidney with ATP-MgCl2 after warm ischemia. American Journal Of Physiology 1984, 247: r1047-r1053. PMID: 6334446, DOI: 10.1152/ajpregu.1984.247.6.r1047.Peer-Reviewed Original ResearchConceptsRenal perfusate flow rateMM ATP-MgCl2Min of perfusionIsolated rat kidneyATP-MgCl2Renal functionWarm ischemiaWhole kidney inulin clearanceRat kidneyAccelerated functional recoveryMin of reperfusionMin of ischemiaUrine flow rateTissue ATP levelsFractional absorptionFunctional recoveryNormothermic ischemiaIschemia resultsMin ischemiaPerfusate flow rateInulin clearanceEarly recoverySystemic effectsIschemiaSodium values