2020
Intrinsic reward circuit connectivity profiles underlying symptom and quality of life outcomes following antidepressant medication: a report from the iSPOT-D trial
Fischer AS, Holt-Gosselin B, Fleming SL, Hack LM, Ball TM, Schatzberg AF, Williams LM. Intrinsic reward circuit connectivity profiles underlying symptom and quality of life outcomes following antidepressant medication: a report from the iSPOT-D trial. Neuropsychopharmacology 2020, 46: 809-819. PMID: 33230268, PMCID: PMC8027440, DOI: 10.1038/s41386-020-00905-3.Peer-Reviewed Original ResearchConceptsMajor depressive disorderISPOT-D TrialReward neurocircuitryFunctional connectivitySymptom respondersQOL responsesAntidepressant medication responseFC relativeQuality of lifeSame time pointsNeural basisAntidepressant medicationVenlafaxine XRSymptom responseDepressive disorderHealthy controlsMedication responseSymptom alleviationADM treatmentADM responsesLife outcomesNeurocircuitrySymptomsTime pointsConnectivity profiles
2019
Worth working for: The influence of effort costs on teens’ choices during a novel decision making game
Sullivan-Toole H, DePasque S, Holt-Gosselin B, Galván A. Worth working for: The influence of effort costs on teens’ choices during a novel decision making game. Developmental Cognitive Neuroscience 2019, 37: 100652. PMID: 31075712, PMCID: PMC6969283, DOI: 10.1016/j.dcn.2019.100652.Peer-Reviewed Original ResearchConceptsGoal pursuitAdolescent decisionEffort-based decision makingPhysical effort costsEffort costsDecision makingEffect of effortReward responsivityTask validityTask motivationDevelopmental differencesDevelopmental researchDevelopmental trajectoriesAppropriate tasksEffort requirementsPreliminary evidenceYoung adultsPrevious researchNew experiencesAdolescenceAdolescentsNovel decisionAdultsWillingnessMaking