2021
Mapping Neural Circuit Biotypes to Symptoms and Behavioral Dimensions of Depression and Anxiety
Goldstein-Piekarski AN, Ball TM, Samara Z, Staveland BR, Keller AS, Fleming SL, Grisanzio KA, Holt-Gosselin B, Stetz P, Ma J, Williams LM. Mapping Neural Circuit Biotypes to Symptoms and Behavioral Dimensions of Depression and Anxiety. Biological Psychiatry 2021, 91: 561-571. PMID: 34482948, PMCID: PMC9511971, DOI: 10.1016/j.biopsych.2021.06.024.Peer-Reviewed Original ResearchConceptsCognitive controlAnxious avoidanceTransdiagnostic symptomsCognitive functionAnxiety disordersAffective circuitsBehavioral dimensionsLoss of pleasurePoorer daily functionBrain circuitsEmotional functionAnxietyNeural circuitsIndependent samplesHealthy reference sampleHuman neural circuitsTreatment targetsDepressionDaily functionIndividual patient levelCircuit assessmentCircuit definitionIntervention treatmentDysfunction scoreClinical scores
2019
Integrating sleep, neuroimaging, and computational approaches for precision psychiatry
Goldstein-Piekarski AN, Holt-Gosselin B, O’Hora K, Williams LM. Integrating sleep, neuroimaging, and computational approaches for precision psychiatry. Neuropsychopharmacology 2019, 45: 192-204. PMID: 31426055, PMCID: PMC6879628, DOI: 10.1038/s41386-019-0483-8.Peer-Reviewed Original ResearchConceptsSleep impairmentAnxiety disordersBrain circuit dysfunctionPrecision psychiatryLarge-scale neural circuitsDefault mode networkMode networkAffective networkPoor sleep qualityExplanatory roleDistal featuresMood symptomsMoodNetwork dysfunctionSleep qualityNeural circuitsSleep disturbancesTestable frameworkCircuit dysfunctionImpairmentPersonalized tailoringDigital phenotypingFuture directionsMachine learning approachesCurrent diagnostic criteria