2021
Reduced functional connectivity of default mode network subsystems in depression: Meta-analytic evidence and relationship with trait rumination
Tozzi L, Zhang X, Chesnut M, Holt-Gosselin B, Ramirez CA, Williams LM. Reduced functional connectivity of default mode network subsystems in depression: Meta-analytic evidence and relationship with trait rumination. NeuroImage Clinical 2021, 30: 102570. PMID: 33540370, PMCID: PMC7856327, DOI: 10.1016/j.nicl.2021.102570.Peer-Reviewed Original ResearchConceptsMajor depressive disorderDefault mode networkFunctional connectivityDMPFC subsystemResting-state functional connectivity changesDiagnosis of MDDDMN subsystemsDiagnostic categoriesDefault mode network subsystemsResting-state functional connectivityFunctional connectivity changesDorsal medial prefrontal cortex (dMPFC) subsystemAnxiety/depressionMedial temporal lobe (MTL) subsystemSubgroup of individualsIllness durationDepressive disorderPrognostic markerDMN connectivityUnmedicated participantsConnectivity changesMidline coreMode networkMeta-analytic evidenceSymptoms
2020
Intrinsic reward circuit connectivity profiles underlying symptom and quality of life outcomes following antidepressant medication: a report from the iSPOT-D trial
Fischer AS, Holt-Gosselin B, Fleming SL, Hack LM, Ball TM, Schatzberg AF, Williams LM. Intrinsic reward circuit connectivity profiles underlying symptom and quality of life outcomes following antidepressant medication: a report from the iSPOT-D trial. Neuropsychopharmacology 2020, 46: 809-819. PMID: 33230268, PMCID: PMC8027440, DOI: 10.1038/s41386-020-00905-3.Peer-Reviewed Original ResearchConceptsMajor depressive disorderISPOT-D TrialReward neurocircuitryFunctional connectivitySymptom respondersQOL responsesAntidepressant medication responseFC relativeQuality of lifeSame time pointsNeural basisAntidepressant medicationVenlafaxine XRSymptom responseDepressive disorderHealthy controlsMedication responseSymptom alleviationADM treatmentADM responsesLife outcomesNeurocircuitrySymptomsTime pointsConnectivity profiles