2024
Familial risk for depression moderates neural circuitry in healthy preadolescents to predict adolescent depression symptoms in the Adolescent Brain Cognitive Development (ABCD) Study
Holt-Gosselin B, Keding T, Rodrigues K, Rueter A, Hendrickson T, Perrone A, Byington N, Houghton A, Miranda-Dominguez O, Feczko E, Fair D, Joormann J, Gee D. Familial risk for depression moderates neural circuitry in healthy preadolescents to predict adolescent depression symptoms in the Adolescent Brain Cognitive Development (ABCD) Study. Developmental Cognitive Neuroscience 2024, 68: 101400. PMID: 38870601, PMCID: PMC11225685, DOI: 10.1016/j.dcn.2024.101400.Peer-Reviewed Original ResearchAdolescent Brain Cognitive DevelopmentAdolescent depressive symptomsDepressive symptomsFamilial riskFunctional connectivityResting-state FC patternsCognitive developmentFamily history of depressionAdolescent-onset depressionLow familial riskHistory of depressionElevated familial riskMixed-effects regression analysisNucleus accumbensStriatal FCLR youthHR youthSensory/somatomotor networkFC patternsNeural circuitryNeural markersDepression riskDepressionPreadolescentsLongitudinal study
2022
Lack of Robust Associations Between Prepandemic Coping Strategies and Frontolimbic Circuitry With Depression and Anxiety Symptoms During the COVID-19 Pandemic: A Preregistered Longitudinal Study
Holt-Gosselin B, Cohodes E, McCauley S, Foster J, Odriozola P, Zacharek S, Kribakaran S, Haberman J, Hodges H, Gee D. Lack of Robust Associations Between Prepandemic Coping Strategies and Frontolimbic Circuitry With Depression and Anxiety Symptoms During the COVID-19 Pandemic: A Preregistered Longitudinal Study. Behavioral Neuroscience 2022, 136: 528-540. PMID: 36395014, PMCID: PMC9884515, DOI: 10.1037/bne0000534.Peer-Reviewed Original ResearchConceptsFrontolimbic circuitryAnxiety symptomsFunctional connectivityMental health outcomesCoping strategiesResting-state functional magnetic resonanceAdaptive coping strategiesLongitudinal studyFunctional magnetic resonanceMental health problemsACC functional connectivityAdaptive copingPreregistered hypothesesInternalizing symptomsNeurobehavioral factorsEmotional responsesPreregistered studyNeurobiological factorsOngoing stressorsElevated symptomsDepression symptomsHealth outcomesCopingCOVID-19 pandemicRobust association
2021
Coping Strategies, Neural Structure, and Depression and Anxiety During the COVID-19 Pandemic: A Longitudinal Study in a Naturalistic Sample Spanning Clinical Diagnoses and Subclinical Symptoms
Holt-Gosselin B, Tozzi L, Ramirez CA, Gotlib IH, Williams LM. Coping Strategies, Neural Structure, and Depression and Anxiety During the COVID-19 Pandemic: A Longitudinal Study in a Naturalistic Sample Spanning Clinical Diagnoses and Subclinical Symptoms. Biological Psychiatry Global Open Science 2021, 1: 261-271. PMID: 34604834, PMCID: PMC8479487, DOI: 10.1016/j.bpsgos.2021.06.007.Peer-Reviewed Original ResearchAnxious arousal symptomsMaladaptive coping strategiesArousal symptomsCoping strategiesSubclinical symptomsBrain regionsNeural structuresGray matter volumePreregistered hypothesesNeural factorsAnhedonia symptomsStressful eventsDepression symptomsGeneral linear mixed-effects modelsNaturalistic sampleLongitudinal studyMatter volumeAmygdala volumeAnxietyLower structural integrityCOVID-19 pandemicT1-weighted scansCortical thicknessPsychiatric diagnosisClinical symptoms