2021
Greater baseline connectivity of the salience and negative affect circuits are associated with natural improvements in anxiety over time in untreated participants
Holt-Gosselin B, Keller AS, Chesnut M, Ling R, Grisanzio KA, Williams LM. Greater baseline connectivity of the salience and negative affect circuits are associated with natural improvements in anxiety over time in untreated participants. Journal Of Affective Disorders 2021, 295: 366-376. PMID: 34492429, DOI: 10.1016/j.jad.2021.08.039.Peer-Reviewed Original ResearchConceptsAnxiety symptom improvementNegative affect circuitSymptoms of anxietyCognitive controlSymptom improvementSad facesLifestyle activitiesPositive affectBehavioral therapyCircuit connectivityBaseline connectivityDefault modeRight insulaPsychosocial functionSocial interactionAnxiety improvementActivity engagementDepression symptomsAnxietySalienceNeural circuit functionNatural improvementUntreated participantsCausal inferenceLimited researchMapping Neural Circuit Biotypes to Symptoms and Behavioral Dimensions of Depression and Anxiety
Goldstein-Piekarski AN, Ball TM, Samara Z, Staveland BR, Keller AS, Fleming SL, Grisanzio KA, Holt-Gosselin B, Stetz P, Ma J, Williams LM. Mapping Neural Circuit Biotypes to Symptoms and Behavioral Dimensions of Depression and Anxiety. Biological Psychiatry 2021, 91: 561-571. PMID: 34482948, PMCID: PMC9511971, DOI: 10.1016/j.biopsych.2021.06.024.Peer-Reviewed Original ResearchConceptsCognitive controlAnxious avoidanceTransdiagnostic symptomsCognitive functionAnxiety disordersAffective circuitsBehavioral dimensionsLoss of pleasurePoorer daily functionBrain circuitsEmotional functionAnxietyNeural circuitsIndependent samplesHealthy reference sampleHuman neural circuitsTreatment targetsDepressionDaily functionIndividual patient levelCircuit assessmentCircuit definitionIntervention treatmentDysfunction scoreClinical scores
2020
The human connectome project for disordered emotional states: Protocol and rationale for a research domain criteria study of brain connectivity in young adult anxiety and depression
Tozzi L, Staveland B, Holt-Gosselin B, Chesnut M, Chang SE, Choi D, Shiner M, Wu H, Lerma-Usabiaga G, Sporns O, Barch DM, Gotlib IH, Hastie TJ, Kerr AB, Poldrack RA, Wandell BA, Wintermark M, Williams LM. The human connectome project for disordered emotional states: Protocol and rationale for a research domain criteria study of brain connectivity in young adult anxiety and depression. NeuroImage 2020, 214: 116715. PMID: 32147367, PMCID: PMC8597395, DOI: 10.1016/j.neuroimage.2020.116715.Peer-Reviewed Original ResearchConceptsHuman Connectome ProjectBilateral dorsolateral prefrontalEmotional statesConnectome dysfunctionsDorsolateral prefrontalPositive Valence Systems domainConnectome ProjectResearch Domain Criteria (RDoC) initiativeCognitive systems domainNegative Valence Systems domainFunctional magnetic resonance imagingNegative emotional facesOccipital cortexPositive emotional experiencesYoung adult anxietyForms of psychopathologyConstructs of interestMultiple diagnostic categoriesEmotional facesCognitive controlNegative emotionsNeurobiological modelsEmotional experienceFusiform gyrusSelf-reported symptoms