Bo Tao, BE, PhD
Associate Research Scientist in PathologyCards
About
Titles
Associate Research Scientist in Pathology
Appointments
Education & Training
- PhD
- Zhejiang University, Basic medical sciences/Pathology & Pathophysiology (2014)
- BE
- Zhejiang University of Technology, Biological and environmental engineering/Biological Engineering (2007)
Research
Publications
2025
Morphological alterations of the thymus gland in individuals with schizophrenia
Zhao Q, Wei X, Yu W, Li X, Gao Z, Liu S, Liu Z, Wang K, Bishop J, Hu H, Luo C, Xiao Y, Hu N, Tao B, Zhu F, Gong Q, Lui S. Morphological alterations of the thymus gland in individuals with schizophrenia. Molecular Psychiatry 2025, 1-11. PMID: 40038543, DOI: 10.1038/s41380-025-02946-w.Peer-Reviewed Original ResearchAverage CT attenuationChest computed tomographyCT attenuationImmunometabolic profileThymic morphologySubtype 1Subtype 2Evidence of immunological abnormalitiesMaximal thicknessAnteroposterior distancePatient subtypesLow CT attenuationMorphological alterationsCase-control comparisonImmunological abnormalitiesThymic sizeLymphocyte countSchizophreniaComputed tomographyLipid measurementsThymus glandImmune hypothesisPatientsImmune systemSubtypesNeurobiological fingerprints of negative symptoms in schizophrenia identified by connectome‐based modeling
Gao Z, Xiao Y, Zhu F, Tao B, Zhao Q, Yu W, Bishop J, Gong Q, Lui S. Neurobiological fingerprints of negative symptoms in schizophrenia identified by connectome‐based modeling. Psychiatry And Clinical Neurosciences 2025, 79: 108-116. PMID: 39815736, DOI: 10.1111/pcn.13782.Peer-Reviewed Original ResearchConceptsConnectome-based predictive modelingNegative symptomsResting-state functional connectivity dataSeverity of negative symptomsDevelopment of novel treatment interventionsPrediction of negative symptomsDrug-naive schizophrenia patientsFirst-episode drug-naive schizophrenia patientsUnique neural substratesNovel treatment interventionsFunctional connectivity dataConnectome-based modelsSchizophrenia psychopathologySchizophrenia patientsNeurobiological mechanismsNeural substratesSymptom-specificSchizophreniaIndependent validation sampleError processNeural fingerprintsTreatment interventionsConnectivity patternsFunctional networksConnectivity data
2024
Multilayer network analysis reveals instability of brain dynamics in untreated first-episode schizophrenia
Gao Z, Xiao Y, Zhu F, Tao B, Zhao Q, Yu W, Sweeney J, Gong Q, Lui S. Multilayer network analysis reveals instability of brain dynamics in untreated first-episode schizophrenia. Cerebral Cortex 2024, 34: bhae402. PMID: 39375878, DOI: 10.1093/cercor/bhae402.Peer-Reviewed Original ResearchConceptsDorsal attention networkFirst-episode schizophreniaNetwork switching rateAntipsychotic treatmentSchizophrenia patientsReduction of negative symptomsResting-state functional magnetic resonance imaging dataUntreated first-episode schizophreniaDrug-naive schizophrenia patientsHealthy controlsFunctional magnetic resonance imaging dataEarly-stage schizophreniaFirst-episode drug-naive schizophrenia patientsInferior parietal lobuleFunctional network activityBrain network activityMagnetic resonance imaging dataNetwork activityAntipsychotic medicationNegative symptomsParietal lobuleAcute psychosisParietal regionsSchizophreniaMultilayer network analysisThe type 2 cytokine Fc–IL-4 revitalizes exhausted CD8+ T cells against cancer
Feng B, Bai Z, Zhou X, Zhao Y, Xie Y, Huang X, Liu Y, Enbar T, Li R, Wang Y, Gao M, Bonati L, Peng M, Li W, Tao B, Charmoy M, Held W, Melenhorst J, Fan R, Guo Y, Tang L. The type 2 cytokine Fc–IL-4 revitalizes exhausted CD8+ T cells against cancer. Nature 2024, 634: 712-720. PMID: 39322665, PMCID: PMC11485240, DOI: 10.1038/s41586-024-07962-4.Peer-Reviewed Original ResearchCD8+ T cellsMammalian target of rapamycinCancer immunotherapyT cellsNext-generation cancer immunotherapyAdoptive T-cell transferImmune checkpoint blockade therapyLong-term complete remissionCurrent cancer immunotherapiesCheckpoint blockade therapyInduce durable remissionsT-cell transferCD8+ TCytokine-based immunotherapyType 2 cytokinesXenograft tumor modelBlockade therapyDurable remissionsComplete remissionAntitumour efficacyTumor modelTarget of rapamycinInterleukin-4Immune responseCD8Single-cell CAR T atlas reveals type 2 function in 8-year leukaemia remission
Bai Z, Feng B, McClory S, de Oliveira B, Diorio C, Gregoire C, Tao B, Yang L, Zhao Z, Peng L, Sferruzza G, Zhou L, Zhou X, Kerr J, Baysoy A, Su G, Yang M, Camara P, Chen S, Tang L, June C, Melenhorst J, Grupp S, Fan R. Single-cell CAR T atlas reveals type 2 function in 8-year leukaemia remission. Nature 2024, 634: 702-711. PMID: 39322664, PMCID: PMC11485231, DOI: 10.1038/s41586-024-07762-w.Peer-Reviewed Original ResearchChimeric antigen receptorChimeric antigen receptor T cellsT cellsIL-4CAR T-cell dysfunctionChimeric antigen receptor T-cell productsCAR-T cell persistenceProteomic profiling of seraCAR-T cellsT cell persistenceT-cell therapyLong-term remissionT cell dysfunctionCAR-T productsType 2 cytokinesAntigen-specific activationT cell productionAssociated with patientsType 2 cellsDysfunctional subsetPotential therapeutic strategyCellular immunotherapyLeukemia remissionPatients relapseType 2 functionsProgressive alterations of resting-state hypothalamic dysconnectivity in schizophrenia
Li X, Zeng J, Liu N, Yang C, Tao B, Sun H, Gong Q, Zhang W, Li C, Lui S. Progressive alterations of resting-state hypothalamic dysconnectivity in schizophrenia. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2024, 135: 111127. PMID: 39181307, DOI: 10.1016/j.pnpbp.2024.111127.Peer-Reviewed Original ResearchHypothalamic functional connectivityBilateral anterior cingulate cortexAnterior cingulate cortexFunctional connectivityFES patientsCingulate cortexFC decreaseRight thalamusChronically treated schizophrenia patientsHealthy controlsSeed-based functional connectivityFirst-episode patientsPathogenesis of schizophreniaNature of schizophreniaAge-related declineAntipsychotic treatmentAntipsychotic medicationRight caudateLeft putamenIllness durationAnalysis of covarianceSchizophreniaDiagnostic groupsHC groupHypothalamus dysfunctionMultivariate associations between neuroanatomy and cognition in unmedicated and medicated individuals with schizophrenia
Zhao Q, Gao Z, Yu W, Xiao Y, Hu N, Wei X, Tao B, Zhu F, Li S, Lui S. Multivariate associations between neuroanatomy and cognition in unmedicated and medicated individuals with schizophrenia. Schizophrenia 2024, 10: 62. PMID: 39004627, PMCID: PMC11247086, DOI: 10.1038/s41537-024-00482-0.Peer-Reviewed Original ResearchFirst-episode schizophreniaCortical surface areaSubcortical volumesMedicated individualsFirst-episode schizophrenia sampleCortical thicknessBrain-behavior profilesAnterior cingulate cortexRight parahippocampal gyrusVerbal fluency testInferior parietal lobuleMultiple cognitive domainsVerbal memory performanceSample of individualsAntipsychotic doseAntipsychotic medicationPsychopathological symptomsCingulate cortexNeurobiological basisFluency testRight caudateMemory performanceParietal lobuleCognitive domainsIllness durationApplications of MRI in Schizophrenia: Current Progress in Establishing Clinical Utility
Sun H, Liu N, Qiu C, Tao B, Yang C, Tang B, Li H, Zhan K, Cai C, Zhang W, Lui S. Applications of MRI in Schizophrenia: Current Progress in Establishing Clinical Utility. Journal Of Magnetic Resonance Imaging 2024, 61: 616-633. PMID: 38946400, DOI: 10.1002/jmri.29470.Peer-Reviewed Original ResearchMagnetic resonance imagingTreatment outcome of schizophreniaOutcome of schizophreniaSevere mental illnessSchizophrenia patientsSchizophreniaIllness onsetPredicting symptomsBrain abnormalitiesClinical utilityMental illnessTreatment outcomesDecades of researchFindings of magnetic resonance imagingScreening high-risk individualsLife of affected individualsHigh-risk individualsPromote clinical translationResonance imagingIncreased mortality rateResponse processApplication of magnetic resonance imagingSymptomsPrognostic toolResearch findingsAltered cerebral white matter network topology and cognition in children with obstructive sleep apnea
Chen F, Fu Y, Tang B, Tao B, Wang Y, Huang Y, Chen T, Yu C, Jiang C, Lui S, Cai X, Lu Y, Yan Z. Altered cerebral white matter network topology and cognition in children with obstructive sleep apnea. Sleep Medicine 2024, 118: 63-70. PMID: 38613858, DOI: 10.1016/j.sleep.2024.03.038.Peer-Reviewed Original ResearchConceptsObstructive apnea-hypopnea indexWhite matter networksVerbal Comprehension IndexNon-OSA childrenEvidence of impaired cognitive functionRight temporal poleSuperior temporal gyrusImpaired cognitive functionBrain white matter networkHierarchical linear regressionApnea-hypopnea indexObstructive sleep apneaNeuroimaging evidenceTemporal gyrusTemporal poleBrain regionsCognitive testsCognitive functionMediation analysisTemporal lobeCognitive impairmentChild's brainNetwork propertiesSleep apneaComprehensive indexIs unilateral cerebellum sufficient? Insights from new cases of cerebellar agenesis and literature review
Deng D, Tao B, Yuan Y, Ao Y, Qiu L. Is unilateral cerebellum sufficient? Insights from new cases of cerebellar agenesis and literature review. Psychoradiology 2024, 4: kkae012. PMID: 39022191, PMCID: PMC11253423, DOI: 10.1093/psyrad/kkae012.Peer-Reviewed Original ResearchCerebellar agenesisFunctional magnetic resonance imagingCerebellar diseaseNon-motor functionsCase of cerebellar agenesisNon-motor domainsMild cognitive impairmentMotor functionSocial behaviorCognitive impairmentPrevent deficitsMild depressionClinical manifestationsSevere autismMotor deficitsCerebellumMagnetic resonance imagingStructural imagingDeficitsImpairmentBrainResonance imagingMotorCerebellar developmentReview pertinent literature