Oligomerization and endocytosis of Hedgehog is necessary for its efficient exovesicular secretion
Parchure A, Vyas N, Ferguson C, Parton R, Mayor S. Oligomerization and endocytosis of Hedgehog is necessary for its efficient exovesicular secretion. Molecular Biology Of The Cell 2015, 26: 4700-4717. PMID: 26490120, PMCID: PMC4678025, DOI: 10.1091/mbc.e15-09-0671.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDrosophila melanogasterDrosophila ProteinsEndocytosisEndosomal Sorting Complexes Required for TransportHedgehog ProteinsImaginal DiscsMetabolic Networks and PathwaysMultivesicular BodiesProtein TransportWings, AnimalConceptsLong-range signalingMultivesicular bodiesEndocytic deliveryDrosophila wing imaginal discWing imaginal discsESCRT proteinsLipidated proteinsSecreted morphogenImaginal discsNanoscale organizationExovesiclesHedgehogSignalingProteinOligomerizationHhDependent processesESCRTSelective effectTurn actMorphogensEndocytosisAqueous milieuSecretionComplexes