2005
Choosing between DNA and RNA: the polymer specificity of RNA helicase NPH-II
Kawaoka J, Pyle AM. Choosing between DNA and RNA: the polymer specificity of RNA helicase NPH-II. Nucleic Acids Research 2005, 33: 644-649. PMID: 15681616, PMCID: PMC548353, DOI: 10.1093/nar/gki208.Peer-Reviewed Original Research
2004
Big engine finds small breaks
Pyle AM. Big engine finds small breaks. Nature 2004, 432: 157-158. PMID: 15538349, DOI: 10.1038/432157a.Peer-Reviewed Original ResearchBackbone tracking by the SF2 helicase NPH-II
Kawaoka J, Jankowsky E, Pyle AM. Backbone tracking by the SF2 helicase NPH-II. Nature Structural & Molecular Biology 2004, 11: 526-530. PMID: 15146171, DOI: 10.1038/nsmb771.Peer-Reviewed Original Research
2002
Group II introns: highly specific endonucleases with modular structures and diverse catalytic functions
Fedorova O, Su LJ, Pyle AM. Group II introns: highly specific endonucleases with modular structures and diverse catalytic functions. Methods 2002, 28: 323-335. PMID: 12431436, DOI: 10.1016/s1046-2023(02)00239-6.Peer-Reviewed Original ResearchThe hepatitis C viral NS3 protein is a processive DNA helicase with cofactor enhanced RNA unwinding
Pang PS, Jankowsky E, Planet PJ, Pyle AM. The hepatitis C viral NS3 protein is a processive DNA helicase with cofactor enhanced RNA unwinding. The EMBO Journal 2002, 21: 1168-1176. PMID: 11867545, PMCID: PMC125889, DOI: 10.1093/emboj/21.5.1168.Peer-Reviewed Original ResearchConceptsRNA unwindingHelicase activityDNA helicase activityCytoplasmic RNA virusesProcessive DNA helicaseImportant drug targetsReplicative DNA intermediatesNS3 helicase activityViral NS3 proteinDNA helicaseDuplex unwindingPhylogenetic analysisReplicative roleProcessive helicaseDNA intermediatesHelicaseHost DNARNA virusesRNA activityRNA replicationDrug targetsNS3 proteinUnwindingCentral roleDNA
1995
Conversion of a group II intron into a new multiple-turnover ribozyme that selectively cleaves oligonucleotides: elucidation of reaction mechanism and structure/function relationships.
Michels WJ, Pyle AM. Conversion of a group II intron into a new multiple-turnover ribozyme that selectively cleaves oligonucleotides: elucidation of reaction mechanism and structure/function relationships. Biochemistry 1995, 34: 2965-77. PMID: 7893710, DOI: 10.1021/bi00009a028.Peer-Reviewed Original Research
1992
RNA catalysis by a group I ribozyme. Developing a model for transition state stabilization.
Cech TR, Herschlag D, Piccirilli JA, Pyle AM. RNA catalysis by a group I ribozyme. Developing a model for transition state stabilization. Journal Of Biological Chemistry 1992, 267: 17479-17482. PMID: 1381347, DOI: 10.1016/s0021-9258(19)37064-4.Peer-Reviewed Original Research