2023
Single‐cell multi‐omics analysis of COVID‐19 patients with pre‐existing autoimmune diseases shows aberrant immune responses to infection
Barmada A, Handfield L, Godoy‐Tena G, de la Calle‐Fabregat C, Ciudad L, Arutyunyan A, Andrés‐León E, Hoo R, Porter T, Oszlanczi A, Richardson L, Calero‐Nieto F, Wilson N, Marchese D, Sancho‐Serra C, Carrillo J, Presas‐Rodríguez S, Ramo‐Tello C, Ruiz‐Sanmartin A, Ferrer R, Ruiz‐Rodriguez J, Martínez‐Gallo M, Munera‐Campos M, Carrascosa J, Göttgens B, Heyn H, Prigmore E, Casafont‐Solé I, Solanich X, Sánchez‐Cerrillo I, González‐Álvaro I, Raimondo M, Ramming A, Martin J, Martínez‐Cáceres E, Ballestar E, Vento‐Tormo1 R, Rodríguez‐Ubreva J. Single‐cell multi‐omics analysis of COVID‐19 patients with pre‐existing autoimmune diseases shows aberrant immune responses to infection. European Journal Of Immunology 2023, 54: e2350633. PMID: 37799110, DOI: 10.1002/eji.202350633.Peer-Reviewed Original ResearchSARS-CoV-2 infectionAutoimmune disease groupImmune responseAutoimmune diseasesDisease groupPre-existing autoimmune diseasePeripheral blood mononuclear cellsPre-existing autoimmune conditionsPre-existing autoimmunitySevere COVID-19Aberrant immune responseGroup of patientsInflammatory T cellsBlood mononuclear cellsCOVID-19 patientsMajor autoimmune diseasesCOVID-19SARS-CoV-2Autoimmune conditionsMononuclear cellsT cellsMonocyte responsePatientsSingle-cell multi-omics analysisInfection
2022
Epigenetic and transcriptomic reprogramming in monocytes of severe COVID-19 patients reflects alterations in myeloid differentiation and the influence of inflammatory cytokines
Godoy-Tena G, Barmada A, Morante-Palacios O, de la Calle-Fabregat C, Martins-Ferreira R, Ferreté-Bonastre A, Ciudad L, Ruiz-Sanmartín A, Martínez-Gallo M, Ferrer R, Ruiz-Rodriguez J, Rodríguez-Ubreva J, Vento-Tormo R, Ballestar E. Epigenetic and transcriptomic reprogramming in monocytes of severe COVID-19 patients reflects alterations in myeloid differentiation and the influence of inflammatory cytokines. Genome Medicine 2022, 14: 134. PMID: 36443794, PMCID: PMC9706884, DOI: 10.1186/s13073-022-01137-4.Peer-Reviewed Original ResearchConceptsDNA methylation alterationsSevere COVID-19 patientsInterferon-related genesCOVID-19 patientsCell typesMethylation alterationsMyeloid differentiationSingle-cell transcriptomesSingle-cell transcriptomicsDNA methylation changesGene expression changesPeripheral blood monocytesImmune cell typesMethylationEPIC BeadChip arraySpecific DNA methylation alterationsTranscriptional reprogrammingDNA methylomeTranscriptomic reprogrammingDNA methylationInflammatory cytokinesMethylation changesEpigenetic alterationsBlood monocytesExpression changesBeadChip array