Single‐cell multi‐omics analysis of COVID‐19 patients with pre‐existing autoimmune diseases shows aberrant immune responses to infection
Barmada A, Handfield L, Godoy‐Tena G, de la Calle‐Fabregat C, Ciudad L, Arutyunyan A, Andrés‐León E, Hoo R, Porter T, Oszlanczi A, Richardson L, Calero‐Nieto F, Wilson N, Marchese D, Sancho‐Serra C, Carrillo J, Presas‐Rodríguez S, Ramo‐Tello C, Ruiz‐Sanmartin A, Ferrer R, Ruiz‐Rodriguez J, Martínez‐Gallo M, Munera‐Campos M, Carrascosa J, Göttgens B, Heyn H, Prigmore E, Casafont‐Solé I, Solanich X, Sánchez‐Cerrillo I, González‐Álvaro I, Raimondo M, Ramming A, Martin J, Martínez‐Cáceres E, Ballestar E, Vento‐Tormo1 R, Rodríguez‐Ubreva J. Single‐cell multi‐omics analysis of COVID‐19 patients with pre‐existing autoimmune diseases shows aberrant immune responses to infection. European Journal Of Immunology 2023, 54: e2350633. PMID: 37799110, DOI: 10.1002/eji.202350633.Peer-Reviewed Original ResearchSARS-CoV-2 infectionAutoimmune disease groupImmune responseAutoimmune diseasesDisease groupPre-existing autoimmune diseasePeripheral blood mononuclear cellsPre-existing autoimmune conditionsPre-existing autoimmunitySevere COVID-19Aberrant immune responseGroup of patientsInflammatory T cellsBlood mononuclear cellsCOVID-19 patientsMajor autoimmune diseasesCOVID-19SARS-CoV-2Autoimmune conditionsMononuclear cellsT cellsMonocyte responsePatientsSingle-cell multi-omics analysisInfectionCytokinopathy with aberrant cytotoxic lymphocytes and profibrotic myeloid response in SARS-CoV-2 mRNA vaccine–associated myocarditis
Barmada A, Klein J, Ramaswamy A, Brodsky N, Jaycox J, Sheikha H, Jones K, Habet V, Campbell M, Sumida T, Kontorovich A, Bogunovic D, Oliveira C, Steele J, Hall E, Pena-Hernandez M, Monteiro V, Lucas C, Ring A, Omer S, Iwasaki A, Yildirim I, Lucas C. Cytokinopathy with aberrant cytotoxic lymphocytes and profibrotic myeloid response in SARS-CoV-2 mRNA vaccine–associated myocarditis. Science Immunology 2023, 8: eadh3455-eadh3455. PMID: 37146127, PMCID: PMC10468758, DOI: 10.1126/sciimmunol.adh3455.Peer-Reviewed Original ResearchConceptsMRNA vaccinesSARS-CoV-2 mRNA vaccinesSARS-CoV-2 mRNA vaccinationC-reactive protein levelsB-type natriuretic peptidePeripheral blood mononuclear cellsCardiac tissue inflammationDeep immune profilingSerum soluble CD163Vaccine-associated myocarditisCohort of patientsBlood mononuclear cellsCytotoxic T cellsLate gadolinium enhancementHypersensitivity myocarditisElevated troponinMRNA vaccinationImaging abnormalitiesNK cellsImmune profilingKiller cellsMyeloid responseNatriuretic peptideHumoral mechanismsInflammatory cytokines