2023
In Utero Electroporated Neurons for Medium-Throughput Screening of Compounds Regulating Neuron Morphology
Sokolov A, Aurich M, Bordey A. In Utero Electroporated Neurons for Medium-Throughput Screening of Compounds Regulating Neuron Morphology. ENeuro 2023, 10: eneuro.0160-23.2023. PMID: 37620147, PMCID: PMC10464655, DOI: 10.1523/eneuro.0160-23.2023.Peer-Reviewed Original ResearchConceptsSomatosensory cortexCortical pyramidal neuronsTreatment of epilepsyNeurite overgrowthNeurologic disabilityPyramidal neuronsSoma sizeNovel agentsCircuit alterationsSide effectsMorphologic assessmentMouse neuronsRelated disordersDiseased neuronsMTOR activatorDrug efficacyCandidate therapeuticsNeuronsNeuron morphologyMTOR activityMedium-throughput screeningNeurodevelopmental disordersNeurite lengthMorphologic measurementsDisorders
2008
GABAA receptors, anesthetics and anticonvulsants in brain development.
Henschel O, Gipson KE, Bordey A. GABAA receptors, anesthetics and anticonvulsants in brain development. CNS & Neurological Disorders - Drug Targets 2008, 7: 211-24. PMID: 18537647, PMCID: PMC2557552, DOI: 10.2174/187152708784083812.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsGABAergic drugsBrain developmentLong-term cognitive deficitsMain inhibitory neurotransmitterFunction of GABANeonatal periodInhibitory neurotransmitterGABAA receptorsMature brainNeuronal excitabilitySide effectsCognitive deficitsClinical perspectiveGABACNS developmentReceptorsReceptor propertiesDrugsAnticonvulsantsAnestheticsBasic scienceReviewSedativesExcitabilityNeurotransmitters